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Ophthalmological implant, method for producing an ophthalmological implant, and use of a ligand for producing an ophthalmological implant

An implant, ophthalmic technology, applied in the direction of eye implants, intraocular lens, chemical instruments and methods, etc., can solve problems such as damage to the function of accommodating IOL

Pending Publication Date: 2021-07-23
CARL ZEISS MEDITEC AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, streaks of fibrosis in particular may continue to impair the function of accommodating IOLs

Method used

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  • Ophthalmological implant, method for producing an ophthalmological implant, and use of a ligand for producing an ophthalmological implant
  • Ophthalmological implant, method for producing an ophthalmological implant, and use of a ligand for producing an ophthalmological implant
  • Ophthalmological implant, method for producing an ophthalmological implant, and use of a ligand for producing an ophthalmological implant

Examples

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Embodiment Construction

[0033] figure 1 A schematic side view of a part of an ophthalmic implant 1 known from the prior art, which in the present case is designed as an intraocular lens, is shown. The implant 1 comprises a haptic portion 2 and an optical portion 3 in a manner known per se. For better understanding, figure 2 show figure 1 Shown is a magnified illustration of detail area II, while image 3 show figure 1 Enlarged illustration of detail region III shown. It can be seen that the implant 1 (in particular in the region of the loop portion 2 ) does not lie continuously flush against the posterior capsular bag 4 due to the fact that the capsular bag 4 forms folds and cavities. Such as figure 2 As schematically illustrated in , the result is that the so-called E cells 5 located in the equatorial region of the capsular bag 4 are mitotically active and often form a cobblestone monolayer, under the influence of transforming growth factor beta (TGF-β) The lower parts gradually dissociate ...

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Abstract

The invention relates to an ophthalmological implant (10) with a main body (12) and at least one ligand (L) immobilized on the main body (12). In the implanted state of the ophthalmological implant (10), the ligand (L) can bind and / or deactivate at least one fibrinogen and / or cytokine. The invention further relates to a method for producing an ophthalmological implant (10), and to a use of a ligand (L), by means of which at least one fibrinogen and / or cytokine is to be bound and / or deactivated in the implanted state of the ophthalmological implant (10), for producing an ophthalmological implant (10).

Description

technical field [0001] The present invention relates to ophthalmic implants, methods for the manufacture of ophthalmic implants and the use of ligands for the manufacture of ophthalmic implants. Background technique [0002] Fibrosis refers to the pathological increase of connective tissue in human and animal tissues, the main component of connective tissue is collagen fibers. As a result, the tissue of the affected organ hardens. The scarring changes that occur can lead to organ-specific functional limitations at an advanced stage. In the case of the use of ophthalmic implants, such as intraocular lenses, the interaction between the implant and adjacent biological tissue means that a number of complications can occur, among which fibrosis in particular is problematic. For example, in some cases, so-called posterior capsule opacification (PCO, secondary cataract) occurs after cataract surgery. PCO is postoperative lens capsule opacification following surgical removal of ...

Claims

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Application Information

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IPC IPC(8): A61F2/16A61K31/00C07K16/22
CPCC07K16/22A61F2210/00A61F2/1624C07K16/244A61K9/0051A61P27/02A61K31/513A61K31/365A61K31/337A61K47/6957A61F2002/1681A61F2240/001A61L27/18A61L27/20A61L27/54A61L2430/16C07K16/245
Inventor A·沃尔夫斯坦
Owner CARL ZEISS MEDITEC AG
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