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Antigen peptide related to lung cancer driver gene mutation and application thereof

A technology of driving genes and antigenic peptides, applied in the field of biomedicine, can solve the problems of failure to form effects, superior therapeutic agents, etc., and achieve good clinical transformation and disease prevention prospects

Active Publication Date: 2021-07-27
上海保亿仁生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, because technology requires multidisciplinary, high-tech, and multi-platform collaborative research, antigenic peptides related to lung cancer driver gene mutations have not been systematically discovered and a relatively complete peptide library has not been established. therapeutic agent

Method used

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  • Antigen peptide related to lung cancer driver gene mutation and application thereof
  • Antigen peptide related to lung cancer driver gene mutation and application thereof
  • Antigen peptide related to lung cancer driver gene mutation and application thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0019] Below, in conjunction with accompanying drawing and specific embodiment, the present invention is described further:

[0020] Antigen peptides related to lung cancer driver gene mutations used in the examples are shown in Table 1:

[0021] Table 1 Antigenic peptide sequences associated with lung cancer driver gene mutations

[0022]

[0023] The operation for the establishment of antigen peptide-specific CTL clones related to lung cancer driver gene mutations is as follows:

[0024] 10 from the same healthy donor 5 CD8 + T cells loaded with 10 antigenic peptides associated with lung cancer driver mutations 4 Mo-DCs were stimulated twice at intervals of 1 week, and then passed autologous 10 5 Mitomycin C-treated PBMCs loaded with antigenic peptides associated with lung cancer driver gene mutations were stimulated once and screened by standard cytotoxicity assays.

[0025] T2 cells were loaded with 5uM antigen peptides related to lung cancer driver gene mutations ...

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PUM

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Abstract

The invention discloses an antigen peptide related to lung cancer driver gene mutation. Lung cancer driver genes are at least two of EGFR, FAT4, KMT2C, KEAP1, KRAS, RB1 and TP53. The sequences of the antigen peptides are at least two of SEQ No.1-47. According to the application of the antigen peptide, the antigen peptide is used for inducing generation of specific cytotoxic T cell clone. The antigen peptide has high affinity with MHC I molecules on DC cells, can effectively stimulate and induce generation of specific cytotoxic T lymphocytes, can be used for immune clearance of tumor cells with lung cancer related driver gene mutation, and has good treatment potential.

Description

technical field [0001] The invention relates to an antigenic peptide related to lung cancer driving gene mutation and application thereof, belonging to the technical field of biomedicine. Background technique [0002] Lung cancer is one of the malignant tumors with the fastest increasing morbidity and mortality and the greatest threat to the health and life of the population. In the past 50 years, many countries have reported that the morbidity and mortality of lung cancer have increased significantly. The incidence and mortality of lung cancer in men rank first among all malignant tumors, and the incidence and mortality of lung cancer occupy the second place in women. Chemotherapy is the main treatment for lung cancer, and more than 90% of lung cancers require chemotherapy. The curative effect of chemotherapy on lung cancer is relatively positive no matter whether it is in the early stage or the late stage. However, chemotherapy treatment also causes great damage to health...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47C07K14/71C12N5/0783A61K39/00A61P35/00
CPCC07K14/4748C07K14/71C12N5/0638A61K39/001104A61K39/001102A61P35/00
Inventor 郝冰娜李许峰蔡睿赵环罗夫辛克纳吉张积仁
Owner 上海保亿仁生物医药有限公司
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