Preparation method of hyaluronic acid microneedle patch

Abstract

The invention relates to a preparation method of a hyaluronic acid microneedle patch, wherein the preparation method comprises the following raw materials: a microneedle solution comprising 10-15% of hyaluronic acid, 5-10% of an active extract, 3-6% of ceramide, 4-8% of hydrolyzed collagen, 6-12% of centella asiatica, 0.5-2% of a preservative and 60-72% of deionized water, and a base stock solution comprising a matrix material polymer and deionized water in a solid-to-liquid ratio of 1:3. The preparation method comprises the following steps: (1) preparation of the microneedle solution: weighing 60-72% of deionized water, slowly adding 10-15% of weighed hyaluronic acid, after the hyaluronic acid is completely swelled, adding 5-10% of an active extract, 3-6% of ceramide, 4-8% of hydrolyzed collagen, 6-12% of centella asiatica and 0.5-2% of a preservative, heating and increasing the stirring speed until the solution is boiled; and (2) preparation of the base stock solution: weighing a matrix material, adding deionized water according to the solid-to-liquid ratio of 1:3, and stirring until the matrix material is dissolved. According to the invention, natural active ingredients are delivered into the skin by adopting a microneedle, so that the hyaluronic acid microneedle patch has the effects of moisturizing, whitening, removing freckles, delaying senescence, resisting allergy, resisting bacteria, resisting inflammation and the like.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to a method for preparing a hyaluronic acid microneedle patch. Background technique [0002] Hyaluronic acid, also known as hyaluronic acid, is a linear polymer polysaccharide composed of glucuronic acid and N-acetylglucosamine as repeating units. It is a biological macromolecular substance widely present in the extracellular matrix of vertebrate tissues. In the field of medicine, hyaluronic acid is also called hyaluronic acid, and the current commercial form of hyaluronic acid is its sodium salt. When hyaluronic acid is applied on the skin surface, it will form a transparent hydration film with viscoelasticity, which has excellent water retention effect, good air permeability, no greasy feeling, and makes the skin feel natural, smooth and soft. With its unique moisturizing effect and physical and chemical properties, hyaluronic acid has become a nationally recognized ex...

AI Technical Summary

Problems solved by technology

[0004] At present, there are many types of hyaluronic acid skin care products on the market, but most of them only stay on the surface of the skin, and the skin care effect is not significant enough

Metal microneedles have high skin penetration, but they cause more trauma to the skin; silicon microneedles have good sensing performance and electromechanical properties, but silicon microneedles are easy to break