Novel tricyclic compound as irak4 inhibitor

A cyclic compound, chemical formula technology, applied in the field of new tricyclic compounds as IRAK4 inhibitors, can solve the problems of inability to greatly improve the disease, high cost, and achieve excellent inhibitory activity.
CN113227095APending Publication Date: 2021-08-06KOREA RES INST OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KOREA RES INST OF CHEM TECH
Publication Date
2021-08-06

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Abstract

The present invention relates to a pharmaceutical composition for preventing or treating autoimmune diseases or tumors, containing, as an active ingredient, a tricyclic compound represented by the following formula 1 or a pharmaceutically acceptable salt thereof, and a health food composition for preventing or alleviating autoimmune diseases or tumors, containing the tricyclic compound as an active ingredient. [Chemical formula 1] A tricyclic compound represented by chemical formula 1 of the present invention has an excellent inhibitory activity against IRAK4, and thus can be effectively used in the prevention, treatment, or alleviation of autoimmune diseases or tumors.
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Description

technical field

[0001] The present invention relates to a novel tricyclic compound as an IRAK4 inhibitor, a pharmaceutical composition for preventing or treating autoimmune diseases or tumors containing the tricyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient, And a health food composition containing the ternary compound as an active ingredient for preventing or improving autoimmune diseases or tumors. Background technique

[0002] IRAK4 (Interleukin-1 receptor (IL-1R) associated kinase 4) acts as a mediator to send Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signals into cells in bone marrow cells and lymphocytes It is the main phosphorylase that is transmitted, and it is being actively studied as a therapeutic target for rare immune diseases such as systemic lupus erythematosus (SLE) and lymphoma (Current Topics in Medicinal Chemistry, 2009, 9, 724-737) .

[0003] Lupus is an autoimmune disease of unknown cause, if 4 or...

Claims

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