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Polyphenolic compound and composition and application of polyphenol compound and composition in preparation of product with anti-aging effect

A technology of polyphenolic compounds and compounds, applied in the field of biomedicine, can solve problems such as increased skin ROS levels, skin oxidative damage, and impaired barrier function, and achieve synergistic inhibition of tyrosinase activity and reduction of lipofuscin synthesis , the effect of prolonging life

Pending Publication Date: 2021-08-10
深圳海创生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The skin can isolate the internal environment of the human body from the external environment and act as a physical barrier, but it is also subject to various harmful stimuli such as physical, chemical, and bacterial infections from the external environment. Long-term external stimuli will induce an increase in the level of skin ROS , resulting in oxidative damage to the skin and impaired barrier function, leading to dermatitis, accelerated aging, etc.

Method used

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  • Polyphenolic compound and composition and application of polyphenol compound and composition in preparation of product with anti-aging effect
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  • Polyphenolic compound and composition and application of polyphenol compound and composition in preparation of product with anti-aging effect

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Experimental program
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Effect test

Embodiment 1

[0040] The preparation of embodiment 1 compound

[0041] (1) Take 50g of bifid yeast fermentation product lysate, add 200mL of chloroform and 2000mL of water to mix and extract, repeat the extraction 3 times, take the water layer, dry at low temperature, and then prepare the compound with the structure shown in formula I by HPLC;

[0042] Wherein the preparation conditions of HPLC are: the determination conditions of high performance liquid chromatography are to adopt Boston Green ODS-AQ chromatographic column (250*4.6mm), with 0.1% trifluoroacetic acid aqueous solution as mobile phase A, with the methanol solution of 0.1% trifluoroacetic acid It is mobile phase A, mobile phase A:mobile phase B=50:50, the flow rate is 2mL / min, the detection wavelength is 310μm, and the injection volume is 100μL. Collect the chromatographic peak at 8.001 min to obtain the compound with the structure shown in formula I.

[0043] The compound of the structure shown in formula I is light yellow o...

experiment example 1

[0051] In order to evaluate the anti-aging activity of the compound or composition of the present invention, the effect of inhibiting tyrosinase activity and reducing lipofuscin synthesis, the present invention carried out the following experiments.

[0052] Put 10 Caenorhabditis elegans on the NGM plate, inoculate Escherichia coli (OP50 strain), and lay eggs for about 5 hours. Then, put the nematodes back on the NGM plate and culture them at 20°C until the offspring of C. elegans reach the L4 larvae.

[0053] On the 0th day of the experiment, the L4 Caenorhabditis elegans larvae were transferred to a composition containing dissolved samples EP, BA, and PA and a mixture of EP, BA, and PA (abbreviated as EBP, and EP, BA, and PA were Equivalent mass ratio) 0.10mg / mL 35mmNGM plate, counted every day. Caenorhabditis elegans that could not move were counted as dead, and the number of nematodes in each group was ≥100, and repeated 3 times.

[0054] On the 0th day of the experiment...

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Abstract

The invention relates to the technical field of biomedicine, and particularly discloses a polyphenol compound and a composition and application of the polyphenol compound and the composition in preparation of a product with an anti-aging effect. The polyphenol compound has a structure as shown in a formula I, a formula II or a formula III. The composition comprises compounds with structures as shown in a formula I, a formula II and a formula III. Researches show that the polyphenol compound with the structure shown in the formula I, the formula II or the formula III can prolong the service life of nematodes, meanwhile, the polyphenol compound with the structure shown in the formula I, the formula II or the formula III also has a tyrosinase inhibition effect, and synthesis of lipofuscin can be effectively reduced; therefore, the polyphenol compound with the structure as shown in the formula I, the formula II or the formula III or the composition thereof can be used for preparing cosmetics, skin care products, food, health care products or medicines with anti-aging and whitening and spot-fading effects.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a polyphenolic compound and composition and its application in preparing products with anti-aging effects. Background technique [0002] The skin is mainly composed of three layers: epidermis, dermis and subcutaneous fat tissue, and is also the largest organ of the human body. The skin can isolate the internal environment of the human body from the external environment and act as a physical barrier, but it is also subject to various harmful stimuli such as physical, chemical, and bacterial infections from the external environment. Long-term external stimuli will induce an increase in the level of skin ROS , leading to oxidative damage to the skin and impaired barrier function, leading to dermatitis and accelerated aging. [0003] The present invention aims at developing a compound with anti-aging effect. Contents of the invention [0004] In view of this, the present inve...

Claims

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Application Information

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IPC IPC(8): C07D311/22C07C235/34A61K31/352A61K31/198A61K8/49A61K8/44A61Q19/08A61Q19/02A61P39/06A61P17/00A61P17/18A23L33/105A23L33/145A23L33/175
CPCC07D311/22C07C235/34A61K31/352A61K31/198A61K8/498A61K8/44A61Q19/08A61Q19/02A61P39/06A61P17/00A61P17/18A23L33/105A23L33/145A23L33/175C07B2200/07A61K2800/782A61K2800/592A61K2800/5922A23V2002/00
Inventor 刘志刚刘杰牛文芳韩艳霞罗强罗丹王志尧王怀玲
Owner 深圳海创生物科技有限公司
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