Construction method of HPLC fingerprint spectrum of granules for treating infantile lung cough

Abstract

The invention relates to a construction method of an HPLC fingerprint spectrum of granules for treating infantile lung cough, and belongs to the medicine field. Aiming at the HPLC fingerprint spectrum of the children lung cough granules, conditions such as a mobile phase, a detection wavelength and a gradient elution procedure are optimized, and fingerprint spectrum detection conditions are established. A standard fingerprint spectrum of the children lung cough granules is established according to multiple batches of samples, 24 common peaks are confirmed in the spectrum, and medicinal material affiliation and component identification are carried out on the related common peaks. According to the method disclosed by the invention, the quality of the children lung cough granules can be relatively comprehensively controlled, so that the quality stability, consistency and controllability of the children lung cough granules are better ensured, and the safety and effectiveness of the children lung cough granules are ensured. According to the method, through systematic component identification and the attribution of single medicinal materials with common peaks in different batches of samples, the current situation of each component in the children lung cough granules is analyzed more comprehensively, and an important reference basis can be provided for quality control of the children lung cough granules.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a method for constructing an HPLC fingerprint of Xiaoer Feike granule. Background technique

[0002] Chinese medicine fingerprints use modern analysis techniques to reflect the chemical components in samples by analyzing and comparing the chromatograms of traditional Chinese medicines or proprietary Chinese medicines. It is often used in clinical component analysis and quality evaluation of Chinese medicines. Just like each person's unique fingerprint, each medicinal material also has its own unique medicinal properties and active ingredients. With the help of modern computer and software analysis technology, each medicinal material can be identified like a fingerprint, and the unique active ingredients can be identified, the internal quality of traditional Chinese medicine can be monitored, and the problem of quality standardization can be fundamentally solved. [...

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