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Method for identifying liquorice component in traditional Chinese medicine composition

An identification method and composition technology, which is applied in the direction of material separation, material analysis, measuring devices, etc., can solve problems such as poor experimental results and inability to determine the basis for review

Pending Publication Date: 2021-08-10
CHANGCHUN RENMIN PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The identification method of the present invention is a general method for qualitative identification of Chinese medicinal compositions containing licorice, which solves the problem of quality control of traditional Chinese medicinal compositions that have not established a detection method for licorice by Chinese medicine manufacturers, and can also be used as a method for existing detection methods that have poor experimental results and cannot be determined. At the same time, it also provides a non-standard inspection method for testing agencies that can determine whether a company with bad credit has added a single extracted component without authorization or detects Chinese patent medicines that have not established a method for the determination of licorice.

Method used

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  • Method for identifying liquorice component in traditional Chinese medicine composition
  • Method for identifying liquorice component in traditional Chinese medicine composition
  • Method for identifying liquorice component in traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0042] (a) Preparation of the test solution:

[0043] Take samples of traditional Chinese medicine compositions in different dosage forms (the dosage is equivalent to 0.5-2.0 g of licorice grassland medicinal materials), add 40-80 ml of diethyl ether to reflux or ultrasonically extract for 30-60 minutes, filter, discard the diethyl ether solution, add methanol or ethanol to the dregs 40-60ml, reflux or sonicate for 30-60 minutes, filter, concentrate the filtrate, add 5-10g of neutral alumina, mix well on a water bath, dry, add to a neutral alumina column (preferably, neutral oxide The bulk density of the aluminum column is 100-200 mesh, the weight is 5-10g, and the inner diameter of the column is 1.5-2.0cm), elute with 50-100ml of 40% methanol, collect the eluate, evaporate to dryness, add water for 20-20ml to the residue 30ml to dissolve, shake and extract twice with water-saturated n-butanol, the amount of water-saturated n-butanol is 20-30ml each time, combine with n-butano...

Embodiment 1

[0058] Example 1 Identification of licorice components in Guilong Jinguning Tablets

[0059] Guilong Jinguning tablet is composed of nineteen Chinese herbal medicines in the following parts by weight:

[0060] 78.1 parts of Chuanshanlong, 39.1 parts of angelica, 39.1 parts of fried peach kernels, 39.1 parts of cinnamon sticks, 39.1 parts of salvia miltiorrhiza, 39.1 parts of ground maple skin, 39.1 parts of grass black, 39.1 parts of frankincense (stir-fried), 39.1 parts of atractylodes (stir-fried), Sichuan beef Knee 39.1, Clematis 39.1, Licorice 39.1, Millennium 39.1, Safflower 39.1, Nyxum powder 19.531.

[0061] The preparation method of Guilong Jinguning tablet is as follows:

[0062] The above fifteen flavors, angelica, atractylodes, and cassia twig are crushed into fine powder; frankincense is boiled with 120ml of water to melt, the decoction is filtered, and the filtrate is set aside. For the other ten flavors such as Chuanshanlong, add water and decoct twice, the fir...

Embodiment 2 4

[0070] Example 2 Identification of licorice components in Sisimamao Tablets

[0071]Four Seasons Cold Tablets are composed of nine traditional Chinese medicinal materials in the following parts by weight:

[0072] 167 parts of bellflower, 250 parts of perilla leaves, 167 parts of tangerine peel, 125 parts of Nepeta, 167 parts of Daqing Ye, 167 parts of forsythia, 83 parts of roasted licorice, 167 parts of sautéed incense, and 125 parts of Fangfeng.

[0073] The preparation method of Four Seasons Cold Tablets is as follows:

[0074] The above nine flavors, platycodon root are crushed into fine powder, and set aside; Perilla leaves, tangerine peel, Nepeta add 8 times the amount of water, steam distilled for 6 hours, collect volatile oil, and the distilled aqueous solution is collected in another device; Daqingye, Forsythia, Glycyrrhiza licorice is decocted twice with water, add 7 times the amount for the first time, add 6 times the amount of water for the second time, each time...

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Abstract

The invention discloses a method for identifying a liquorice component in a traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese medicines and natural medicines. The method comprises the following diversified extraction and purification steps of removing impurities by using diethyl ether, extracting by using methanol or ethanol, purifying by using a neutral alumina column, extracting by using water-saturated n-butyl alcohol, and purifying by using n-butyl pure-saturated water, and is characterized in that a dichloromethane-acetone-methanol-water expansion system is selected, and exclusive characteristic spots are taken as a judgment basis; the quality defect that a single extraction component is added arbitrarily by an enterprise with poor credit is overcome; and the method is not only suitable for quality control of the licorice-containing traditional Chinese medicine composition in industrial production, but also can be used as a non-standard inspection standard, and provides a powerful quality control monitoring means for medicine market supervision.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and natural medicine, and in particular relates to an identification method of licorice components in a traditional Chinese medicine composition. Background technique [0002] As a commonly used medicinal material in traditional Chinese medicine compositions, licorice not only has the functions of invigorating the spleen and Qi, clearing away heat and detoxification, eliminating phlegm and relieving cough, but also has the function of reconciling various drugs and alleviating their properties. Licorice was first recorded in "Shen Nong's Materia Medica", known as "ten medicines and nine licorices" and "Chinese old medicine", and "Compendium of Materia Medica" listed it as the first of all medicines. Another medical masterpiece "Treatise on Febrile Diseases" contained 113 prescriptions, including about 70 prescriptions containing licorice. In the current edition of "Chinese Pha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/94G01N30/06
CPCG01N30/90G01N30/94G01N30/06
Inventor 王士青苏英南黄青
Owner CHANGCHUN RENMIN PHARMA GROUP
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