Preparation method of a three-dimensional diabetic foot ulcer functional medical dressing

A functional technology for diabetic foot ulcers, applied in the field of medical devices, can solve problems such as low production efficiency, large amount of post-processing, complex preparation process, etc.

Active Publication Date: 2022-05-17
WUYI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the preparation process of three-dimensional medical dressings in the prior art is relatively complicated, requiring a lot of post-processing, and the production efficiency is low

Method used

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  • Preparation method of a three-dimensional diabetic foot ulcer functional medical dressing
  • Preparation method of a three-dimensional diabetic foot ulcer functional medical dressing
  • Preparation method of a three-dimensional diabetic foot ulcer functional medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0039] This embodiment has prepared a kind of three-dimensional diabetic foot ulcer medical dressing, and specific process comprises:

[0040] (1) Preparation of aqueous solution

[0041] (1) Preparation of sodium alginate aqueous solution (NaA), polyvinyl alcohol aqueous solution (PVA) and chitosan aqueous solution (CS): sodium alginate powder and deionized water are mixed to prepare a certain concentration (preferably about 2wt%) , the present embodiment is 2wt% sodium alginate aqueous solution; polyvinyl alcohol powder (Shanghai Titan Technology Co., Ltd., model: 9002-89-5) is mixed with deionized water to prepare a certain concentration (preferably 1wt%) About, this embodiment is 1wt%) polyvinyl alcohol aqueous solution; Mix chitosan powder and 1% (v / v) acetic acid, prepare the shell of certain concentration (preferably about 1wt%, this embodiment is 1wt%) polysaccharide aqueous solution;

[0042] (2) Preparation of indomethacin, a drug mixed aqueous solution of MMPs inhib...

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Abstract

The invention discloses a preparation method of a three-dimensional diabetic foot ulcer functional medical dressing, which comprises the following steps: S1, taking a core layer solution, an intermediate layer solution and a shell layer solution; printing through a microfluidic 3D printing component to make the The inner phase channel leads to the core layer solution, the middle phase channel leads to the middle layer solution, and the outer phase channel leads to the shell solution; S2. Control the flow rate in each channel and set the 3D printer parameters so that the flow rate of the inner phase channel is 0 ~ 110mL / h , the flow rate of the mesophase channel is 150-270mL / h, and the flow rate of the outer phase channel is 30-110mL / h. A 3D printer is used to control the microfluidic chip to print a three-dimensional functional medical dressing for diabetic foot ulcers. Through the control of the speed of the scheme of the present invention, it can be assembled into a three-dimensional structure composed of multi-layer shell / core structure microfibers, the size can be adjusted and has good swelling rate, water absorption rate, etc., and has good application in medical care products for diabetic foot ulcers prospect.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a preparation method of a three-dimensional diabetic foot ulcer functional medical dressing. Background technique [0002] Diabetes is a chronic metabolic disease worldwide, accompanied by premature death, high morbidity and medical costs. Research data shows that many diabetic patients will suffer from foot wound infection in their lifetime and cause non-healing chronic ulcers. Among them, some diabetic foot ulcer (DFU) patients need amputation because they cannot heal, which is the primary cause of non-traumatic amputation and seriously affects Human physical and mental health and quality of life. In recent years, in order to achieve DFU wound healing, clinical treatment methods include debridement, prevention of bacterial infection, negative pressure drainage, hyperbaric oxygen therapy, physical therapy, blood transfusion therapy-platelet-rich plasma, tissue transpl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/28A61L15/24B33Y10/00B33Y80/00B33Y70/10
CPCA61L15/44A61L15/28A61L15/24B33Y10/00B33Y80/00B33Y70/10A61L2300/41A61L2300/434A61L2300/216C08L5/04C08L5/08C08L29/04
Inventor 于晖黄琪帏吴廷斌
Owner WUYI UNIV
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