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Application of phenolic acid ester compound

A technology of phenolic acid esters and compounds, applied in the application field of phenolic acid ester compounds, can solve the problems of easy repeated disease course, strong adverse reactions, low safety and the like

Active Publication Date: 2021-08-17
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In view of this, the application provides an application of phenolic acid ester compounds, which can effectively solve the technical problems of easy recurrence of disease course, strong adverse reactions and low safety in the existing prevention or treatment of influenza virus drugs

Method used

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  • Application of phenolic acid ester compound
  • Application of phenolic acid ester compound
  • Application of phenolic acid ester compound

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0056] The preparation scheme of the feruloyl oligosaccharide in the embodiment of the present application includes: drying the corn bran raw material, crushing, and passing through a 40-mesh sieve; first removing residual starch and protein with high-temperature-resistant α-amylase and protease, and then boiling Inactivate the enzyme, dry the filtered residue, add oxalic acid at a ratio of 1:1, heat, stir, and filter, and use ultrafiltration equipment to remove unacidified soluble macromolecules from the filtrate; adsorb the permeate through resin, and wash the resin with water to remove low polysaccharides, and then eluted with ethanol aqueous solution; the ethanol eluate was concentrated and dried to obtain feruloyl oligosaccharides.

[0057] The oseltamivir used in the examples of this application was purchased from Aladdin Company.

Embodiment 1

[0061] The embodiment of the present application provides a test of influenza virus infection in mice treated with feruloyl oligosaccharides. The specific steps are as follows:

[0062] 1. 40 mice (female to male ratio of 1:1) were randomly divided into five groups, such as figure 1 as shown, figure 1 It is a schematic diagram of the experiment of mice infected with influenza virus provided in the examples of this application.

[0063] NC group: the mice were intragastrically administered with the same amount of normal saline every day from Day 1 to Day 21, and finally sacrificed on the 21st day.

[0064] VC group: 15 days before the mice were infected with influenza virus, that is, from Day 1 to Day 15, the mice were given intragastric administration of the same amount of normal saline every day, and then injected with influenza virus on the 16th day (Day 16), and given the same amount of normal saline for intragastric administration every day. 5 days, and finally executed ...

Embodiment 2

[0081] The embodiment of the present application provides a test of influenza virus infection in mice after the mixture of corn bran feruloyl oligosaccharides and ferulic acid in a weight ratio of 10:1, the specific steps are as follows:

[0082] 1. 40 mice (female to male ratio of 1:1) were randomly divided into five groups, such as figure 1 as shown, figure 1 It is a schematic diagram of the experiment of mice infected with influenza virus provided in the examples of this application.

[0083] NC group: the mice were intragastrically administered with the same amount of normal saline every day from Day 1 to Day 21, and finally sacrificed on the 21st day.

[0084] VC group: 15 days before the mice were infected with influenza virus, that is, from Day 1 to Day 15, the mice were given intragastric administration of the same amount of normal saline every day, and then injected with influenza virus on the 16th day (Day 16), and given the same amount of normal saline for intragas...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to application of a phenolic ester compound. The invention provides application of the phenolic ester compound in preparation of a medicine for preventing and / or treating influenza viruses. The phenolic acid ester compound is feruloyl oligosaccharide. Specifically, the medicine for preventing and / or treating the influenza viruses further comprises ferulic acid. The invention further provides the medicine for preventing and treating the influenza viruses. The medicine comprises feruloyl oligosaccharide and pharmaceutically acceptable adjuvants. The invention provides the application of the phenolic acid ester compound. The phenolic acid ester compound can effectively solve the technical problems that a disease course is easy to repeat, an adverse reaction is strong and safety is low in existing medicines for preventing or treating the influenza viruses.

Description

technical field [0001] The application belongs to the technical field of biomedicine, and in particular relates to the application of a phenolic acid ester compound. Background technique [0002] Influenza virus is called influenza virus for short. It is divided into three types: A (A), B (B), and C (C). Influenza viruses that have only been discovered in recent years will be classified as D (D). Influenza viruses can cause infection and disease in many animals such as humans, poultry, pigs, horses, and bats, and are the pathogens of human and animal diseases such as human influenza, avian influenza, swine influenza, and equine influenza. Typical clinical symptoms of these blights are acute high fever, generalized pain, marked fatigue and respiratory symptoms. Influenza viruses are mainly spread through droplets in the air, contact between a susceptible person and an infected person, or contact with contaminated items. Generally, autumn and winter are the peak periods. H...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61K31/192A61K31/715A61P37/04A61P31/16C07H13/04C07H1/06C12P19/14C12P19/04C12P19/12C12P19/00C08B37/00
CPCA61K31/7024A61K31/192A61K31/715A61P37/04A61P31/16C07H13/04C07H1/06C12P19/14C12P19/04C12P19/12C12P19/00C08B37/00A61K2300/00
Inventor 黄俊卿邓力郑洁欧隽滢郝闻致
Owner JINAN UNIVERSITY
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