Novel marker for auxiliary diagnosis of valvular heart disease and auxiliary diagnosis product

A technology for assisting diagnosis and heart disease, applied in the field of biomedicine

Active Publication Date: 2021-08-24
GUANGDONG BEATING ORIGIN REGENERATIVE MEDICINE CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the relationship between PLAUR and valvular heart disease in the world

Method used

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  • Novel marker for auxiliary diagnosis of valvular heart disease and auxiliary diagnosis product
  • Novel marker for auxiliary diagnosis of valvular heart disease and auxiliary diagnosis product
  • Novel marker for auxiliary diagnosis of valvular heart disease and auxiliary diagnosis product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Serum collection from healthy volunteers or patients with valvular heart disease

[0019] 1.1 Sample recruitment of healthy volunteers: healthy volunteers were recruited voluntarily and signed informed consent. The number of healthy volunteers included in this study was 27, including 14 males and 13 females. The age distribution was as follows: 8 people were 21-30 years old, 11 people were 31-40 years old, 3 people were 41-50 years old, and 5 people were 51-60 years old.

[0020] 1.2 Collection of patients with valvular heart disease: The patients with valvular heart disease included in this study were admitted to Nanhai Hospital of Guangdong Provincial People's Hospital and completed blood collection. This study was carried out under the condition that the patients were informed and voluntarily signed the informed consent. Among the patients in this study, there were 23 males and 25 females. The age distribution was as follows: 1 patient was 70 years old....

Embodiment 2

[0022] Embodiment 2: Serum NT-ProBNP level detection

[0023] 2.1: Sample preparation: Freshly separated serum can be tested directly; if it is a frozen sample, it needs to be thawed at room temperature and mixed thoroughly by low-speed vortex or inversion.

[0024] 2.2: Detection of NT-ProBNP level: NT-ProBNP level was detected according to the instructions of Brain Natural Peptide N-terminal Precursor Protein Assay Kit (chemiluminescent method) (New Industry, 130206004M).

[0025] Result analysis: if figure 2 , as shown in Table 1, the serum NT-ProBNP level of patients with valvular heart disease was significantly higher than that of healthy volunteers, but the NT-ProBNP level of 34.5% (20 / 58) patients still had been diagnosed in the normal range, indicating that the NT-ProBNP level was in the normal range. Sensitivity / accuracy of ProBNP levels as a biomarker of valvular heart disease is suboptimal. Therefore, it is not comprehensive to use only NT-ProBNP as a biomarker i...

Embodiment 3

[0026] Example 3: Detection of serum hsCRP level

[0027] 3.1: Sample preparation: Freshly separated serum can be tested directly; if it is a frozen sample, it needs to be thawed at room temperature and mixed thoroughly by low-speed vortex or inversion.

[0028] 3.2: Detection of hsCRP level: The hsCRP level was detected according to the instructions of the C-reactive protein assay kit (chemiluminescent method) (New Industry, 130216002M).

[0029] Result analysis: if image 3 , as shown in Table 1, 31.0% (18 / 58) of serum hsCRP levels in patients with confirmed valvular heart disease are displayed in the normal range, indicating that the sensitivity / accuracy of using hsCRP levels as biomarkers of valvular heart disease not ideal.

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Abstract

The invention provides a novel marker for auxiliary diagnosis of a valvular heart disease and an auxiliary diagnosis product. According to the present invention, a novel biomarker PLAUR capable of being adopted as the auxiliary diagnosis of the valvular heart disease is found for the first time, the detection speed is rapid, the result can be obtained only in one workday, at the same time, the detection sensitivity / accuracy is far higher than the NT-ProBNP and the hsCRP, and the high-throughput operation can be achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular refers to a novel marker for auxiliary diagnosis of valvular heart disease and a product for auxiliary diagnosis. Background technique [0002] Valvular Heart Disease (VHD) refers to abnormalities in the anatomical structure and function of one or more valves caused by congenital developmental malformations or acquired lesions, leading to valve stenosis and / or insufficiency, mainly including aortic valve stenosis ( AS) or regurgitation (AR), mitral stenosis (MS) or regurgitation (MR), etc. [0003] Once the stenosis or insufficiency of the heart valve occurs, it will directly affect the normal blood flow in the heart, increase the burden on the heart, cause damage to heart function, and eventually lead to heart failure and death of the patient. Valvular heart disease is a common cardiovascular disease that endangers human life and health, and its incidence gradually increas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/32G01N2333/70596G01N33/54387G01N33/6887
Inventor 林彬曾嵘孔维维
Owner GUANGDONG BEATING ORIGIN REGENERATIVE MEDICINE CO LTD
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