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Radix stephaniae tetrandrae and radix astragali decoction and application of components thereof in preparation of myocardial hypertrophy resisting medicine

A technology of Fangji Huangqi Decoction and myocardial hypertrophy, which is applied in the direction of medical formula, drug combination, and resistance to vector-borne diseases, etc., can solve problems such as no basic research reports, achieve significant cardiomyocyte hypertrophy, improve cardiac function, and have a wide range of sources Effect

Active Publication Date: 2021-08-27
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the pharmacological studies of Fangji Huangqi Decoction and its components against heart failure, and there are no relevant basic research reports on its anti-cardiac hypertrophy.

Method used

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  • Radix stephaniae tetrandrae and radix astragali decoction and application of components thereof in preparation of myocardial hypertrophy resisting medicine
  • Radix stephaniae tetrandrae and radix astragali decoction and application of components thereof in preparation of myocardial hypertrophy resisting medicine
  • Radix stephaniae tetrandrae and radix astragali decoction and application of components thereof in preparation of myocardial hypertrophy resisting medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Preparation of Fangji Huangqi Decoction and Components thereof

[0049] Take 60g of medicinal materials Fangji, 75g of Astragalus membranaceus, 45g of Atractylodes macrocephala, 30g of licorice, 45g of ginger, and 36g of jujube, add water to decoct; filter the obtained decoction, concentrate under reduced pressure to obtain a paste, which is Fangji Huangqi Decoction;

[0050] After dispersing the paste of Fangji Huangqi Decoction with water, it is separated by a macroporous adsorption resin column, eluted with water, 20% ethanol, 40% ethanol, and 95% ethanol in sequence, and each eluate is collected, and the eluate is concentrated under reduced pressure , vacuum-dried, wherein 40%, 95% ethanol eluent dried for Fangji Huangqi Decoction component A and component B.

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Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses a radix stephaniae tetrandrae and radix astragali decoction and application of components thereof in preparation of myocardial hypertrophy resisting medicine. The radix stephaniae tetrandrae and radix astragali decoction is prepared from 50-70 g of radix stephaniae tetrandrae, 60-90 g of radix astragali, 35-55 g of rhizoma atractylodis macrocephalae, 20-40 g of radix glycyrrhizae, 35-55 g of fresh ginger and 25-45 g of fructus ziziphi jujubae, and the radix stephaniae tetrandrae and radix astragali decoction is obtained after the raw materials are decocted with water, filtered and concentrated under reduced pressure. The radix stephaniae tetrandrae and radix astragali decoction is dispersed with water and then eluted with water, 15-22% ethyl alcohol, 35-45% ethyl alcohol and 90-100% ethyl alcohol in sequence, and 35-45% ethyl alcohol eluent and 90-100% ethyl alcohol eluent are a component A and a component B of the radix stephaniae tetrandrae and radix astragali decoction; animal pharmacodynamic study confirms that the radix stephaniae tetrandrae and radix astragali decoction, the component A and the component B can obviously improve the heart function level of a heart failure model mouse, reduce serum heart failure markers, relieve inflammatory response, improve pathological changes of heart tissues and play an obvious role in resisting the heart failure of the mouse; certain development potential is realized in the aspect of preparing medicines for treating myocardial hypertrophy.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to the application of Fangji Huangqi Decoction and its components in the preparation of anti-cardiac hypertrophy drugs. Background technique [0002] Heart failure (HF) refers to a group of clinical syndromes caused by abnormalities in the structure or function of the heart due to various reasons, resulting in impaired heart pumping function, mainly manifested as dyspnea, fluid retention, and physical fatigue. Ventricular remodeling is an important process in the development of heart failure, and cardiac hypertrophy is one of the key pathological links in the process of ventricular remodeling. Myocardial hypertrophy is an important stage in the development of many heart diseases. Pathological myocardial hypertrophy refers to the decompensated response caused by excessive activation or long-term overload of the heart. fibrosis etc. Persistent pathological myoc...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P9/04
CPCA61K36/59A61K36/481A61K36/284A61K36/484A61K36/9068A61K36/725A61P9/04A61K2236/331A61K2236/51A61K2236/55A61K2300/00Y02A50/30
Inventor 赵筱萍杨振中王毅
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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