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Cytokine IL-27 as NEC and FPIES differential diagnosis marker and application of cytokine IL-27

A technology for differential diagnosis of IL-27, applied in the field of medicine, can solve problems such as recurrent disease, aggravated allergic state, and infant injury, and achieve good specificity, sensitivity, and good diagnostic efficiency

Pending Publication Date: 2021-08-27
CHONGQING MEDICAL UNIVERSITY
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Benefits of technology

This patented technology allows scientists to easily detect if they are infected by certain viruses or bacteria while also identifying their presence within different types of tissues such as blood cells (white blood cell). It does this through an assay called Lymphocyte Interferon Epsilon Receptor Inhibitor 1(LIR) which helps distinguish between these two groups of microorganisms based upon how well its activity works against them.

Problems solved by technology

This patented technical problem addressed by this patents relates to differentiating between different diseases caused by ingestion of milk products during pregnancy from those due to other causes like metabolism disorders.

Method used

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  • Cytokine IL-27 as NEC and FPIES differential diagnosis marker and application of cytokine IL-27
  • Cytokine IL-27 as NEC and FPIES differential diagnosis marker and application of cytokine IL-27
  • Cytokine IL-27 as NEC and FPIES differential diagnosis marker and application of cytokine IL-27

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Embodiment 1

[0041] 1. Research object

[0042] The research subjects of the present invention were all from the Children's Hospital Affiliated to Chongqing Medical University (June 2019 to December 2020). In this study, we recruited 214 patients with suspected NEC and 54 infants with physiological jaundice as healthy controls. Before collecting the enrolled patients, we established strict inclusion criteria according to the modified Bell staging, with one or more of the following clinical symptoms suspected of NEC: lethargy, vomiting, gastric retention, abdominal distension, blood in the stool; exclusion criteria, (1) Patients who are unwilling to participate in this study (2) Patients with major congenital malformations (3) Patients with genetic diseases (4) Patients with missing information (5) Patients with other non-NEC and non-FPIES intestinal diseases. Patients with suspected NEC were then divided into NEC group (n=78), FPIES group (n=51), other intestinal disease group (n=85) and ...

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Abstract

The invention relates to a cytokine IL-27 as a marker for differential diagnosis of neonatal necrotizing enterocolitis (NEC) and food protein-induced enterocolitis syndrome (FPIES) and an application of the cytokine IL-27, and belongs to the technical field of medicines. The invention provides a novel differential diagnosis marker mainly aiming at the problem of difficulty in differential diagnosis of NEC and FPIES. The expression level of IL-27 in the blood plasma of NEC and FPIES children is higher than that of a normal control group, the expression level of IL-27 in the blood plasma of NEC and FPIES children is higher than that of FPIES children, NEC and FPIES can be well identified according to the level of IL-27 in the blood plasma, the sensitivity is 84.93, the specificity is 81.63, and the area under an ROC curve is 0.877. The plasma IL-27 as a differential diagnosis marker of NEC and FPIES has better diagnosis efficiency, can provide reference for pediatricians, and is beneficial to clinical decision making.

Description

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Claims

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Application Information

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Owner CHONGQING MEDICAL UNIVERSITY
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