Cytokine IL-27 as NEC and FPIES differential diagnosis marker and application of cytokine IL-27
A technology for differential diagnosis of IL-27, applied in the field of medicine, can solve problems such as recurrent disease, aggravated allergic state, and infant injury, and achieve good specificity, sensitivity, and good diagnostic efficiency
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[0041] 1. Research object
[0042] The research subjects of the present invention were all from the Children's Hospital Affiliated to Chongqing Medical University (June 2019 to December 2020). In this study, we recruited 214 patients with suspected NEC and 54 infants with physiological jaundice as healthy controls. Before collecting the enrolled patients, we established strict inclusion criteria according to the modified Bell staging, with one or more of the following clinical symptoms suspected of NEC: lethargy, vomiting, gastric retention, abdominal distension, blood in the stool; exclusion criteria, (1) Patients who are unwilling to participate in this study (2) Patients with major congenital malformations (3) Patients with genetic diseases (4) Patients with missing information (5) Patients with other non-NEC and non-FPIES intestinal diseases. Patients with suspected NEC were then divided into NEC group (n=78), FPIES group (n=51), other intestinal disease group (n=85) and ...
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