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A kind of protamine-pdrn complex, composition and application in preparation of skin care products

A-PDRN, protamine technology, applied in the field of functional skin care products, can solve the problems of reduced efficacy, easy to produce allergies, cumbersome steps, etc., to achieve the effect of enhancing transdermal absorption, improving bioavailability, and clear effective ingredients

Active Publication Date: 2022-03-29
润辉生物技术(威海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, products with skin care effects such as oil control, pore shrinkage, acne treatment, and scar repair include traditional Chinese medicine / plant extracts, antibiotics, and chemically synthesized small molecules. The raw material preparation method is to inject DNA molecules into the skin through a gene gun (Bio-Jet molecular atomizer). However, this method needs to be completed in a professional institution, which limits its scope of application; Plant extract; patent CN110269898A uses salicylic acid, clindamycin
Among them, traditional Chinese medicine products add a variety of plant extracts, the active ingredient structure is not clear, the chemical composition is complex, the active ingredient content is low, the mechanism of action is not clear, and the steps of extracting active ingredients from plants are relatively cumbersome, the content and function of active ingredients The effect is easily affected by different origins and sources of different years; oral administration of zinc sulfate or zinc gluconate is likely to cause gastrointestinal irritation, nausea, vomiting and constipation and other adverse reactions; long-term use of antibiotic ingredients is likely to lead to bacterial resistance and reduce the curative effect , the therapeutic effect cannot be achieved; and some products are prone to side effects such as allergies due to differences in skin sensitivity between individuals

Method used

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  • A kind of protamine-pdrn complex, composition and application in preparation of skin care products
  • A kind of protamine-pdrn complex, composition and application in preparation of skin care products
  • A kind of protamine-pdrn complex, composition and application in preparation of skin care products

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The construction of embodiment 1 protamine-PDRN complex

[0053] (1) First, mix 20mg / L protamine solution and 20mg / L PDRN solution according to the N / P ratio of 1.5:1, and stir at room temperature for 1h; (2) then let the mixture stand at room temperature for 1h; (3 ) Finally, the mixture was freeze-dried to obtain the protamine-PDRN complex.

Embodiment 2

[0054] The construction of embodiment 2 protamine-PDRN complex

[0055] (1) First, mix 20mg / L protamine solution and 20mg / L PDRN solution according to the N / P ratio of 2.0:1, and stir at room temperature for 1h; (2) Then let the mixture stand at room temperature for 1h; (3 ) Finally, the mixture was freeze-dried to obtain the protamine-PDRN complex.

Embodiment 3

[0056] Example 3 Construction of protamine-PDRN complex

[0057] (1) First, mix 20mg / L protamine solution and 20mg / L PDRN solution according to the N / P ratio of 2.5:1, and stir at room temperature for 1h; (2) Then let the mixture stand at room temperature for 1h; (3 ) Finally, the mixture was freeze-dried to obtain the protamine-PDRN complex.

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PUM

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Abstract

The invention specifically relates to a protamine-PDRN complex, composition and application in the preparation of skin care products. The invention provides a protamine-PDRN complex, which has the effect of inhibiting the growth of Propionibacterium acnes. The present invention further provides a product for treating acne and blemishes based on the protamine-PDRN complex, which includes the protamine-PDRN complex, functional polypeptides and other matrix components. When the product is applied to human skin, it has good oil control, acne treatment, acne marks improvement, and whitening effects, and can fundamentally nourish skin cells and improve skin cell metabolism. It is safe to human body, has no toxic and side effects, has extremely high biological safety, and provides its preparation and application methods at the same time.

Description

technical field [0001] The invention belongs to the technical field of functional skin care products, and in particular relates to a protamine-PDRN complex, a composition and an application in preparing skin care products. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Acne, also known as pimples or pimples, is a common chronic inflammatory skin disease that occurs in oily skin and teenagers aged 13 to 24 years. Thickness, scarring, and hyperpigmentation seriously affect the external image, self-confidence and social activities of teenagers, causing unnecessary psychological burden. Nowadays, with the change of diet structure and lifestyle, the mental stress caused by t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/60A61P17/10A61P31/04A61Q17/00A61Q19/00
CPCA61K8/64A61K8/606A61Q19/00A61Q17/005A61P17/10A61P31/04
Inventor 姬胜利王盈盈殷金岗
Owner 润辉生物技术(威海)有限公司
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