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Marker molecules related to the prognosis of gastric cancer

A prognostic and gastric cancer technology, which can be used in the determination/examination of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc., and can solve the problems of screening HubGenes and building risk prediction models.

Active Publication Date: 2022-06-07
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no comprehensive prognostic model construction for gastric cancer samples based on m6ARNA methylation regulators combined with tumor immune cell infiltration, and there is no report on the construction of a risk prediction model combined with m6ARNA methylation regulators and tumor immune cell infiltration screening HubGenes

Method used

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  • Marker molecules related to the prognosis of gastric cancer
  • Marker molecules related to the prognosis of gastric cancer
  • Marker molecules related to the prognosis of gastric cancer

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Experimental program
Comparison scheme
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Embodiment

[0048] 1. Data acquisition

[0049] The gene expression profile data of gastric cancer (STAD) patient samples and control samples (32 cases) were obtained from the TCGA database, and the mutation information and survival information (DFS) of the patient samples were obtained from the cBioportal website (http: / / www.cbioportal.org / ). ), age information, pathological stage and other clinical information, and selected samples with clear survival information and pathological stage and expression values, a total of 267 cases.

[0050] The dataset numbered GSE62254 was downloaded from the GEO database (http: / / www.ncbi.nlm.nih.gov / geo / ), and the chip platform was GPL570, which contained gene expression profile data and survival information of 300 gastric cancer patient samples.

[0051] 31 m6A methylation regulators with different roles in the methylation process were obtained from the literature: Writers (methyltransferases)-METTL3, METTL14, METTL16, WTAP, VIRMA (KIAA1429), RBMX, ZC3...

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Abstract

The present invention relates to marker molecules related to gastric cancer prognosis, said marker molecules include such as SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO : 6, at least one gene sequence shown in SEQ ID NO: 7, SEQ ID NO: 8 and SEQ ID NO: 9. The marker molecules selected by the present invention in combination with m6A modification characteristics and tumor immune microenvironment may play an important role in the prognosis evaluation of gastric cancer patients.

Description

technical field [0001] The present invention relates to the field of cancer treatment and prognosis evaluation, in particular to marker molecules and detection kits related to the prognosis of gastric cancer. Background technique [0002] Gastric cancer is one of the most common digestive tract tumors worldwide. With the advancement of bioinformatics technology and medical means, genome analysis has become the main method for discovering new biological targets of gastric cancer in the world. Studies have shown that epigenetic modifications of the genome, including DNA methylation, histone modifications, and RNA modifications, play an important role in tumorigenesis and development, and the extensive dysregulation of epigenetic changes in cancer and the dynamic changes of these modifications are characteristic of tumors. Therapeutic intervention and prognostic prediction provide the possibility. 6-methyladenine (m6A) is one of the most common post-transcriptional modificati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12N15/11G16H50/30G16H50/20
CPCC12Q1/6886G16H50/30G16H50/20C12Q2600/118C12Q2600/158C12Q2600/154
Inventor 王艳余和芬黄蔚霍苗苗
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES