Mesalazine gargle for treating chemotherapy oral mucositis, and preparation method of Mesalazine gargle

A technology of oral mucositis and mesalazine, which is applied in the field of gargle, can solve the problems of treating the symptoms but not the root cause, not effectively reducing the concentration of OFRs, and easy recurrence of oral mucosal inflammation, achieving economic benefits, convenient clinical medication, and significant treatment effect of effect

Pending Publication Date: 2021-09-07
GUANGDONG KELUN PHARMACEUTICAL CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the effect of these drugs is only to relieve oral discomfort or prevent secondary infection, and treat the symptoms but not the root cause, and cannot effectively reduce the concentration of OFRs, which leads to recurrent oral mucosal inflammation

Method used

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  • Mesalazine gargle for treating chemotherapy oral mucositis, and preparation method of Mesalazine gargle
  • Mesalazine gargle for treating chemotherapy oral mucositis, and preparation method of Mesalazine gargle
  • Mesalazine gargle for treating chemotherapy oral mucositis, and preparation method of Mesalazine gargle

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Embodiment Construction

[0023] In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from this description, and those skilled in the art can make similar extensions without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0024] A mesalazine gargle for treating chemotherapy oral mucositis, the mesalazine gargle is an aqueous solution, and contains the following components in mass and volume percent concentration (w / v%):

[0025] Mesalazine D Surfactant flavoring agent pH regulator Example 1 0.25 0.5 0.75 0.1 0.1 Example 2 0.5 1.0 0.15 0.2 0.2 Example 3 1.0 2.0 3.0 0.4 0.3 Example 4 1.5 3.0 4.5 0.6 0.4

[0026] Among the above raw materials, the particle size of mesalazine is controlled a...

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Abstract

The invention provides a Mesalazine gargle for treating chemotherapy oral mucositis, and a preparation method of the Mesalazine gargle. The Mesalazine gargle is an aqueous solution and contains the following components in the mass volume percentage concentration (w / v%): 0.5-1.0% of Mesalazine, 0.5-3.0% of wetting agents, 1.0-5.0% of surfactants, 0.1-0.5% of flavoring agents and 0.1-0.3% of pH regulators. The Mesalazine gargle for treating the chemotherapy oral mucositis is convenient for clinical medication, can effectively reduce the concentration of OFRs, and has a good treatment effect for the oral mucositis.

Description

technical field [0001] The invention relates to the field of gargles, in particular to a mesalazine gargle for treating chemotherapy oral mucositis and a preparation method thereof. Background technique [0002] Mesalazine (Mesalazine) is the common name of 5-aminosalicylic acid (5-aminosalicylic acid, 5-ASA). Its properties are off-white crystalline powder, odorless, tasteless, and its color gradually becomes darker when exposed to light. Mesalazine is very slightly soluble in water, insoluble in ethanol, chloroform or propanol, and soluble in dilute hydrochloric acid and dilute sodium hydroxide solution. The therapeutic effect of mesalazine mainly depends on the local contact between the drug and the mucosal lesion. The results of in vitro experiments show that mesalazine can inhibit the biosynthesis and release of some inflammatory mediators (prostaglandins, leukotriene B4, C4), and can Scavenge oxygen free radicals (OFRs), thereby improving conjunctival inflammation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/10A61K47/26A61K47/32A61K31/606A61P1/02
CPCA61K9/08A61K9/006A61K47/10A61K47/26A61K47/32A61K31/606A61P1/02
Inventor 叶伟庆齐岩董灵敏严慧玲温孟秋刚俊杰李慧敏赵明雪丘文登邹城刘文彬
Owner GUANGDONG KELUN PHARMACEUTICAL CO LTD
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