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Impeller and sparger assemblies for a bioprocessing system

A technology of biological treatment and biological treatment bag, which is applied in the field of impeller and injector components, can solve the problems of bulky disposable bags, increased complexity and cost of vessel and bag design, troublesome installation, etc.

Active Publication Date: 2021-09-14
GLOBAL LIFE SCI SOLUTIONS USA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for single-use bioreactors, the use of multiple impellers results in bulky disposable bags that cannot be folded efficiently
Additionally, longer shafts with multiple impellers require stabilization, which adds complexity and cost to the vessel and bag design, and makes bag installation more cumbersome and less user-friendly

Method used

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  • Impeller and sparger assemblies for a bioprocessing system
  • Impeller and sparger assemblies for a bioprocessing system
  • Impeller and sparger assemblies for a bioprocessing system

Examples

Experimental program
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Embodiment Construction

[0042] Reference will now be made in detail to the exemplary embodiments of the present invention, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference symbols are used throughout the figures to refer to the same or like parts.

[0043]As used herein, the terms "flexible" or "foldable" refer to structures or materials that are pliable or capable of bending without breaking, and may also refer to materials that are compressible or expandable. An example of a flexible structure is a bag made of polyethylene film. The terms "rigid" and "semi-rigid" are used interchangeably herein to describe a structure that is "non-foldable", that is, does not fold, fold or otherwise deform under normal force to substantially reduce its elongated dimension Structure. Depending on the context, "semi-rigid" may also mean a structure that is more flexible than a "rigid" element (eg, a bendable tube or catheter), but still a structure that does not ...

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PUM

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Abstract

A sparger assembly (700) for a bioprocessing system includes a base plate (710) and at least one aeration manifold (712, 714) removably connected to the base plate. Each aeration manifold includes at least one inlet for receiving a gas and a plurality of gas outlet openings for delivering the gas to a fluid within the bioprocessing system. An impeller assembly (740) for a bioprocessing system includes a hub and at least one blade (742) operatively connected to the hub. The at least one blade includes a first portion connected to the hub and extending generally vertically, and a second portion extending at an upward angle from the first portion.

Description

technical field [0001] Embodiments of the present invention relate generally to biological treatment systems and methods, and more particularly to impeller and ejector assemblies for single-use bioreactor systems. Background technique [0002] A variety of vessels, devices, components and unit operations are known for carrying out biochemical and / or biological processes and / or manipulating liquids and other products of such processes. To avoid the time, expense and difficulty associated with sterilizing vessels used in biopharmaceutical manufacturing, single-use or disposable bioreactor bags and single-use mixing bags serve as such vessels. For example, biological materials (eg, animal and plant cells) including, for example, mammalian, plant or insect cells and microbial cultures can be processed using single-use or single-use mixers and bioreactors. [0003] In the biopharmaceutical industry, single-use or disposable containers are increasingly used. Such containers may ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F3/04B01F7/00B01F13/08B01F15/00C12M1/00C12M1/06
CPCB01F33/4535B01F35/513B01F23/231151B01F23/23125B01F23/231266B01F23/23362B01F23/23123B01F27/113C12M29/06B01F2101/44C12M27/04C12M27/02C12M23/26C12M23/14B01F23/233B01F27/1111B01F23/2311
Inventor R·达姆伦T·贝克尔C·托希R·斯坦科夫斯基S·R·班达鲁S·巴拉克里什南T·法尔克曼P·勒格雷韦斯T·达尔摩N·饶M·皮特松M·达什
Owner GLOBAL LIFE SCI SOLUTIONS USA LLC