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Reagent for detecting breast cancer axillary lymph node metastasis and application thereof

A technology of lymph node metastasis, lymph node, applied in the field of biomedicine

Inactive Publication Date: 2021-09-17
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, about 18 F-Alfatide II detects axillary lymph node metastasis of breast cancer, but there is still no relevant report

Method used

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  • Reagent for detecting breast cancer axillary lymph node metastasis and application thereof
  • Reagent for detecting breast cancer axillary lymph node metastasis and application thereof
  • Reagent for detecting breast cancer axillary lymph node metastasis and application thereof

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0028] 1. Patient information

[0029] This study was approved by the Ethics Committee of the Eastern Theater General Hospital (approval number: 2015NZYW-007) and registered on the clinical trial website (registration number: NCT02582801). Patient inclusion criteria: traditional imaging examination suspected breast cancer; breast lesions without any treatment; 18 years old < age < 70 years old. Exclusion criteria include: pregnancy or breastfeeding; concomitant serious diseases (such as liver and kidney dysfunction, active tuberculosis, other malignant tumors). 44 female patients (age range: 28-66 years; mean age: 50.73±8.01 years) were included in this study, and each patient signed an informed consent.

[0030] 2. PET / CT acquisition

[0031] 18 F-Alfatide II was synthesized and prepared according to the method reported in the literature (Guo J, Lang L, Hu S, etal. Comparison of three dimeric 18 F-ALF-NOTA-RGD tracers. Mol Imaging Biol, 2014, 16:274-83.). 18 F-Alfatide I...

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Abstract

The invention discloses a reagent for detecting breast cancer axillary lymph node metastasis and application thereof. The invention relates to application of 18F-Alfatide II or a combination of 18F-Alfatide II and 18F-FDG in PET / CT detection of breast cancer axillary lymph node metastasis. After intravenous injection of a PET / CT tracer 18F-Alfatide II or 18F-FDG to a patient, PET / CT examination is carried out, and 18F-Alfatide II T / NT has the highest Youden index (76.5%), specificity (100%), accuracy (89.2%) and positive predicted value (100%). The data show that 18F-Alfatide II T / NT may be the most valuable semi-quantitative parameter for evaluating axillary lymph nodes.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a reagent for detecting axillary lymph node metastasis of breast cancer and its application. Background technique [0002] Axillary lymph nodes are the most common metastatic sites of breast cancer, and the status of axillary lymph nodes determines the stage, treatment strategy and prognosis of breast cancer patients. Involvement of axillary lymph nodes in breast cancer usually means later stage, expansion of surgical operation, systemic treatment and lower survival rate. Axillary lymph node metastasis is also the most important predictor of recurrence and survival in breast cancer patients. Therefore, identifying axillary Lymph node metastasis is critical for breast cancer patients. The gold standard for diagnosing axillary lymph node metastasis is surgical resection of lymph nodes, but this method will bring some complications, such as arm edema, pain, neuropathy, etc. Although minima...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/08A61K51/04A61K101/02
CPCA61K51/082A61K51/0491
Inventor 卢光明陈小元吴江朱虹张龙江潘璟
Owner NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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