Standardized preparation method and application of traditional Chinese medicine formula granule cream formula

A traditional Chinese medicine formula granule and a technology for formula granules, which are applied in the directions of pharmaceutical formulas, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. There are no quantitative standards and other issues, to avoid quality differences, shorten the time of boiling the paste, and control the end point of the paste

Pending Publication Date: 2021-09-21
LIAONING HUANREN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In traditional paste preparation, the source and quality of medicinal materials are different. In the actual paste preparation process, there is a large gap in the production quantity and quality between different batches; There is no uniform requirement for the number of decoctions, and s

Method used

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  • Standardized preparation method and application of traditional Chinese medicine formula granule cream formula
  • Standardized preparation method and application of traditional Chinese medicine formula granule cream formula
  • Standardized preparation method and application of traditional Chinese medicine formula granule cream formula

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0044] Example 1 (Nourishing liver and kidney formula)

[0045]Paste formulations brewed using particles, the particles need to be reconstituted formulation amount of water, reconstitution embodiment, the temperature of water was added, the temperature Aogao, Aogao time, the amount of gelatin, the amount of honey, the amount of citric acid and other verification parameters and experimental study.

[0046] 1, prescription:

[0047]

[0048] 2. Test Method:

[0049] 2.1, reconstituted the way study

[0050] The average weighed two nourishing liver and kidney Paste formulations particles, wherein the particles are a good formula weighed slowly into hot water, stirred to dissolve, another hot water is slowly poured into particles, and stirred to dissolve observed dissolution time and record the results shown in Table 1-1

[0051] Table 1-1 Dispensing Granule adding water study

[0052] Water method Repair time (min) Phenomenon Granular plus into hot water 10 All of ...

Example Embodiment

[0094] 2 (granule formulation Pingxin Fumai Paste) Example

[0095]

[0096] 1.1 swap prescription:

[0097] Application of Chinese medicine formulations particles swap equipment for prescription transfers formulated in accordance with a prescribed amount, a total of 617g of particles.

[0098] 1.2 Reconstitution:

[0099] Paste machine in the pot, the total weight of the particles were added 1.3-fold amount of water (802g), the incubation temperature and the set temperature Aogao 55 ℃, time is set to 10min, heating was started with stirring, when the temperature reaches above 50 ℃, slow slow adding swap good Chinese medicine granules 617g.

[0100] 1.3 Aogao:

[0101] After the particles are completely dissolved, the temperature and the holding temperature is set to Aogao 85 ℃, setup time 42 minutes, the drug solution was concentrated gradually become clear thick paste. (In this case the application Abbe Refractometer measured refractive index as 1.471; density measurement to o...

Example Embodiment

[0104] 3 (granule formulation Warming kidney Paste) Example

[0105] Prescription and prescription volume:

[0106]

[0107] 1.1 swap prescription:

[0108] Application of Chinese medicine formulations particles swap equipment for prescription transfers formulated in accordance with a prescribed amount, a total of 565g of particles.

[0109] 1.2 Reconstitution:

[0110] Paste machine in the pot, the total weight of the particles were added 1.3-fold amount of water (735g), the incubation temperature and the set temperature Aogao 55 ℃, time is set to 10min, heating was started with stirring, when the temperature reaches above 50 ℃, slow slow adding swap good Chinese medicine granules 565g.

[0111] 1.3 Aogao:

[0112] After the particles are completely dissolved, the temperature and the holding temperature is set to Aogao 85 ℃, setup time 38 minutes, the drug solution was concentrated gradually become clear thick paste. (In this case the application Abbe Refractometer measured ref...

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Abstract

The invention provides a standardized preparation method and application of a traditional Chinese medicine formula granule cream formula, and belongs to the technical field of standardized treatment of traditional Chinese medicines. The cream formula is decocted from traditional Chinese medicine formula granules, the yin nourishing cream formula adopts donkey-hide gelatin as a matrix, the yang tonifying cream formula adopts deer-horn glue as a matrix, the donkey-hide gelatin and the deer-horn glue can also be formula granules prepared from the donkey-hide gelatin and the deer-horn glue, the cream decoction time can be shortened, and the tedious procedure of melting by heat is avoided. The traditional Chinese medicine formula granules are used for preparing the cream formula, the preparation process is standardized by screening and optimizing related process conditions, tests prove that the method can be applied to the traditional Chinese medicine formula granule cream formula with different prescriptions and different doses, the preparation time of the cream formula can be effectively shortened, the quality difference of different batches of cream formula caused by human factors is avoided, and thus the method has good practical application value.

Description

technical field [0001] The invention belongs to the technical field of standardized treatment of traditional Chinese medicines, and in particular relates to a preparation method and application of standardized traditional Chinese medicine formula granules. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] "Ointment" is a traditional Chinese medicine ointment taken for the main purpose of health care, also known as "ointment", which is one of the oldest prescription forms. A pasty oral preparation prepared with excipients such as glue or honey. Based on the overall concept of traditional Chinese medicine, the ointment is widely used in the treatment of diseases in internal ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K36/8984A61K47/46A61K47/12A61P1/14A61P1/16A61P13/12A61K36/9068A61P9/00A61K36/8998A61K35/586A61K33/26A61K35/50A61K35/02A61K35/618A61K35/57A61K35/64A61K35/36
CPCA61K9/06A61K9/0053A61K36/21A61K36/736A61K36/8945A61K36/46A61K36/815A61K36/754A61K36/884A61K35/586A61K36/8968A61K36/8964A61K36/39A61K36/43A61K36/342A61K36/8984A61K36/28A61K36/704A61K36/71A61K36/65A61K36/888A61K36/725A61K36/605A61K33/26A61K36/79A61K36/57A61K36/62A61K36/126A61K35/50A61K36/752A61K36/738A61K36/287A61K36/48A61K36/076A61K36/77A61K36/756A61K36/804A61K36/638A61K36/232A61K36/12A61K36/54A61K36/9068A61K36/60A61K36/344A61K35/02A61K35/618A61K36/84A61K36/237A61K36/286A61K36/185A61K36/537A61K36/488A61K36/481A61K36/69A61K35/57A61K36/00A61K36/284A61K36/484A61K36/296A61K36/64A61K36/746A61K36/714A61K36/487A61K36/52A61K36/899A61K36/73A61K36/236A61K36/234A61K36/8962A61K36/835A61K36/8998A61K35/64A61K36/8905A61K36/88A61K36/233A61K36/539A61K36/87A61K36/238A61K36/346A61K36/9066A61K36/8967A61K36/8888A61K35/36A61K47/46A61K47/12A61P1/14A61P1/16A61P13/12A61P9/00A61K2300/00
Inventor 赫爱平杨玉王辉张可宋祈潼苑鹏翀赵立新
Owner LIAONING HUANREN PHARMA
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