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Application of curcumin metabolite in preparation of medicine for treating myocardial ischemia related injury

A technique for myocardial ischemia and metabolites, which is applied in drug combinations, cardiovascular system diseases, pharmaceutical formulations, etc., to reduce the degree of ventricular enlargement, reduce pathological manifestations, and improve damaged cardiac function and serum myocardial enzyme performance.

Active Publication Date: 2021-10-01
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

However, there is no report on whether metabolites also have the effect of interfering with MIRI

Method used

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  • Application of curcumin metabolite in preparation of medicine for treating myocardial ischemia related injury
  • Application of curcumin metabolite in preparation of medicine for treating myocardial ischemia related injury
  • Application of curcumin metabolite in preparation of medicine for treating myocardial ischemia related injury

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Embodiment Construction

[0023] In order to make the technical problems, technical solutions and advantages to be solved by the present invention clearer, the following will describe in detail in conjunction with specific embodiments.

[0024] The present invention first compares the effect of curcumin and its metabolites on the RAW264.7 macrophage model induced by bacterial lipopolysaccharide (LPS), selects metabolites with higher activity to study whether it has a therapeutic effect on MIRI, and further utilizes transcription Omics technology was used to explore the prognosis of MIRI disease and the influence of curcumin metabolites on the process of MIRI, so as to provide a theoretical basis for curcumin metabolites to be used in the treatment of MIRI.

[0025] English abbreviations English full name Chinese full name α-HBDH Alpha-hydroxybutyrate dehydrogenase alpha-hydroxybutyrate dehydrogenase AI Apoptotic Index apoptosis index ɑ-SMA alpha-smooth muscle actin...

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Abstract

The invention provides an application of curcumin metabolite in preparation of a medicine for treating myocardial ischemia related injury. The research on the intervention effect of a rat MIRI model finds that both CUR and OHC can improve the impaired heart function and serum myocardial enzyme expression, relieve the ventricular enlargement degree, reduce myocardial cell apoptosis and tissue fibrosis-like change and relieve the pathological expression of MIRI, and the improvement effect of OHC is slightly excellent. Therefore, the molecular mechanism of the MIRI disease process can be known, and a valuable scientific basis is provided for explaining the pharmacodynamic action mechanism of the CUR and the active metabolite OHC of the CUR.

Description

technical field [0001] The invention relates to the application of curcumin metabolites in the preparation of medicines for treating myocardial ischemia-related injuries. Background technique [0002] The incidence of ischemic cardiomyopathy is increasing year by year, seriously endangering human health. In the clinical treatment guidelines, early recovery of blood perfusion in the ischemic area is the key to rescue, but perfusion also brings more serious damage, which will further aggravate ischemic damage in a short time, and then cause ventricular remodeling, Symptoms such as arrhythmia, and eventually even develop into heart failure. This phenomenon of restoring blood perfusion and further aggravating myocardial injury is called myocardial ischemia-reperfusion injury (Myocardial Ischemia Reperfusion Injury, MIRI). MIRI is a complex pathophysiological process involving multiple factors. It is very common in clinical practice, such as thrombolysis and stent implantation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K31/09A61P9/10A61K36/9066A61K125/00
CPCA61K31/12A61K31/09A61P9/10A61K36/9066
Inventor 谢庆凤徐洋苏子仁陈金芬
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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