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Method for synthesizing lacthydrazide

A technology of lactic hydrazide and hydrazine hydrate, applied in the fields of organic synthesis, pharmaceutical and chemical industry, can solve the problems of high price and non-renewable, and achieve the effect of high-value degradation and utilization

Pending Publication Date: 2021-10-08
DONGGUAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention proposes a method for synthesizing lactohydrazide, which overcomes the disadvantages of non-renewable and expensive raw materials for synthesizing lactohydrazide, and develops a method for synthesizing lactohydrazide with green and renewable polylactic acid

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  • Method for synthesizing lacthydrazide

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Embodiment 1

[0016] A method for synthesizing lactohydrazide, the method is as follows:

[0017] (1) Put 10 g of polylactic acid and 30 mL of hydrazine hydrate into a 50 ml reactor. The reactor was heated to 40°C at 6°C / min and kept at 40°C for 12 hours.

[0018] (2) Cool to room temperature after the reaction to obtain a homogeneous reaction solution; the homogeneous reaction solution was vacuum rotary evaporated at 90° C. to remove the residual hydrazine hydrate solution, and filtered to obtain 13.9 g of a white product. GC-MS analysis of the white product dissolved in methanol (see figure 1 ) and mass spectrometry (see figure 2 ), the product was determined to be lactohydrazide.

Embodiment 2

[0020] A method for synthesizing lactohydrazide, the method is as follows:

[0021] (1) Take 10 g of polylactic acid and 20 mL of hydrazine hydrate in a 50 ml reactor. The temperature of the reactor was raised to 60°C at 6°C / min and kept at 60°C for 12 h.

[0022] (2) Cool to room temperature after the reaction to obtain a homogeneous reaction solution; after quantitative analysis by GC-MS, the solution contains 12.8g of lactohydrazide.

Embodiment 3

[0024] (1) Take 10 g of polylactic acid and 20 mL of hydrazine hydrate in a 50 ml reactor. The reactor was heated to 30°C at 6°C / min and kept at 30°C for 24h.

[0025] (2) Cool to room temperature after the reaction to obtain a homogeneous reaction solution; after quantitative analysis by GC-MS, the solution contains 12.7g of lactohydrazide.

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Abstract

The invention provides a method for synthesizing lacthydrazide. According to the method, green renewable polylactic acid is used as a raw material, and the lacthydrazide is prepared at a mild temperature. The invention aims to overcome the defects of usage of non-renewable raw materials, high price and the like of existing lacthydrazide synthesis, and discloses the method for synthesizing lacthydrazide by using green and renewable polylactic acid. Based on the mass of the raw material polylactic acid, the yield of lacthydrazide reaches 139 wt%. According to the method, polylactic acid is efficiently converted into lacthydrazide through one-step reaction, and the method has industrial application prospects.

Description

technical field [0001] The invention relates to the fields of organic synthesis, medicine and chemical industry, and in particular to a method for synthesizing lactohydrazide. Background technique [0002] Lacthydrazide (also known as 2-hydroxypropionyl hydrazide, English name Lacthydrazide; molecular formula C 3 h 8 N 2 o 2 ) is an important fine chemical intermediate. Lactohydrazide contains both active groups hydroxyl and hydrazide, and has a wide range of uses, such as in organic synthesis, pharmaceutical and chemical industries, and other fields. At present, lactohydrazide can be prepared from the expensive fine chemical methyl 2-hydroxypropionate, but this limits the large-scale industrial production and application of lactohydrazide. [0003] Currently, the use of biomass-based polyesters (such as polyhydroxyalkanoate, polylactic acid, etc.) to prepare high-value fine chemicals has become an important technology. For example, polyhydroxyalkanoate can be used to ...

Claims

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Application Information

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IPC IPC(8): C07C241/04C07C243/28
CPCC07C241/04C07C243/28
Inventor 康世民刘越钊钟沛金章羽仪庞翊淇陈素霞邱杨辉
Owner DONGGUAN UNIV OF TECH
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