New use of Cigu extract and composition for delaying lens opacity and preparation method thereof

A technology of extract and composition, applied in the application field of traditional Chinese medicine, can solve the problems of poor availability of cataract surgery, cost-effective surgery, etc., and achieve the effects of significantly delaying lens opacity, significant therapeutic effect, and convenient use.

Active Publication Date: 2022-07-05
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the only effective way to treat ARC is surgical treatment, but surgery is cost-effective, and there is a huge economic burden, especially in remote and poor rural areas in developing countries where medical resources are scarce, cataract surgery is less accessible, and surgery itself is There are certain risks and complications. Therefore, it is of great significance to find non-surgical measures that are cost-effective and have few side effects to prevent the occurrence and development of ARC and to deal with the grim situation of population aging.

Method used

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  • New use of Cigu extract and composition for delaying lens opacity and preparation method thereof
  • New use of Cigu extract and composition for delaying lens opacity and preparation method thereof
  • New use of Cigu extract and composition for delaying lens opacity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] In vitro cell experiments confirm that Symbifolia extract (SSP) helps protect against hydrogen peroxide-induced damage of human lens epithelial cells HLEB3

[0087] 1 Experimental material

[0088] 1.1 Experimental cells

[0089] Human lens epithelial cell line HLEB3 cell line (gifted by the Second Affiliated Hospital of Zhejiang University School of Medicine). HLEB3 cells were seeded in 100 U·ml containing 10% fetal bovine serum -1 Penicillin and 100U·ml -1 Streptomycin in DMEM high glucose medium at 37 °C, 5% CO 2 The cells were statically cultured in a saturated humidity cell incubator, digested with 0.25% trypsin, and passaged, and the cells in the logarithmic growth phase were used for the experiment.

[0090] 1.2 Experimental drugs

[0091] Cigu extract

[0092] 1.3 Experimental reagents and instruments

[0093] 1.3.1 Experimental reagents

[0094] Hydrogen peroxide (H 2 O 2 ) (Beijing Soleibao Company), trypsin, penicillin, PBS (Wuhan Sevier Biotechnology...

Embodiment 2

[0127] In vitro lens culture experiments confirm that Citrus radix extract helps to delay hydrogen peroxide-induced lens opacity

[0128] 1 Experimental material

[0129] 1.1 Experimental organization

[0130] Rabbit lens (Japanese white rabbit, common grade, half male and female), rat lens (SD rat, half male and female). The obtained lens was placed in a place containing 5k U·L -1 Penicillin, 50k U·L -1 Streptomycin M-199 medium and incubate at 37 °C, 5% CO 2 Culture in a saturated humidity cell incubator. After 24 hours of culture, the transparent lens was selected for subsequent experiments.

[0131] 1.2 Experimental drugs

[0132] Cigu extract

[0133] 1.3 Experimental reagents and instruments

[0134] 1.3.1 Experimental reagents

[0135] Hydrogen peroxide (H 2 O 2 ) (Beijing Soleibo Co., Ltd.), carbon dioxide, penicillin, streptomycin, PBS, eye fixative solution, (Wuhan Sevier Biotechnology Co., Ltd.); Medium199 (M-199) medium, Hank's reagent (Biological Indust...

Embodiment 3

[0178] A composition for delaying lens opacity, the active ingredients are composed of Ciquilla extract, Shudi extract, Shengdi extract, Lycium barbarum extract, Bletilla striata extract, Scrophulariaceae extract, Cimicifuga extract and Alisma orientalis extract . Among them, Cigu extract 60kg, Shudi extract 10kg, Shengdi extract 10kg, Lycium barbarum extract 10kg, Bletilla striata extract 10kg, Scrophulariaceae extract 10kg, Cimicifuga extract 5kg and Alisma extract 5kg.

[0179] The above-mentioned preparation method of the composition with the function of delaying lens opacity, the specific preparation steps are as follows:

[0180] (1) Weigh Cigu extract, Shudi extract, Shengdi extract, Lycium barbarum extract, Bletilla striata extract, Scrophulariaceae extract, Cimicifuga extract and Alisma orientalis extract as raw materials according to the formula;

[0181] (2) All components are mixed evenly.

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Abstract

The present invention provides a new use of the extract of Citrus japonica, a composition for delaying lens opacity, and a preparation method thereof. The drug for lens opacity or prevention and treatment of cataract has important clinical application value; the active ingredients of the composition are composed of Cigu extract, Shudi extract, Shengdi extract, Lycium barbarum extract, Bletilla striata extract, Scrophulariaceae extract, Li The hemp extract and the Alisma extract are composed, the components act synergistically, and the effect of delaying the turbidity of the lens is remarkable; the preparation method is simple, the use is convenient, and it is suitable for the needs of large-scale industrial production.

Description

technical field [0001] The invention relates to the application field of traditional Chinese medicine, in particular to a new use of Cigu extract, a composition for delaying lens opacity and a preparation method thereof. Background technique [0002] Age-related cataract (ARC) is the most common type of cataract, and its prevalence increases with age. If left untreated, it will eventually develop into severe visual impairment and even blindness, bringing huge health problems and economic burdens to society. [0003] At present, the only effective way to treat ARC is surgery, but surgery is cost-effective and has a huge economic burden, especially in remote and impoverished rural areas in developing countries, where medical resources are scarce, and the availability of cataract surgery is poor. There are certain risks and complications. Therefore, it is of great significance to find cost-effective and non-surgical measures with few side effects to prevent the occurrence and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61K36/898A61K9/48A61K9/16A61P27/02A61P27/12
CPCA61K36/884A61K36/804A61K36/815A61K36/898A61K36/808A61K36/71A61K9/1623A61P27/12A61P27/02A61K2236/331A61K2236/53A61K2236/51A61K2300/00Y02A50/30
Inventor 廖艳刘文胜罗维早张烯
Owner BEIJING UNIV OF CHINESE MEDICINE
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