Histidine dipeptide composition for repairing liver injury and application of histidine dipeptide composition

A technology of liver injury and peptide composition, applied in the field of histidine dipeptide composition for repairing liver injury, and histidine dipeptide composition, to achieve excellent liver cell damage, reduce liver index, and inhibit liver lipid peroxidation Effect

Active Publication Date: 2021-11-02
GUANGDONG OCEAN UNIVERSITY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the combination of carnosine and anserine on the repair of liver function damage, especially the repair of liver function damage induced by high uric acid

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Histidine dipeptide composition for repairing liver injury and application of histidine dipeptide composition
  • Histidine dipeptide composition for repairing liver injury and application of histidine dipeptide composition
  • Histidine dipeptide composition for repairing liver injury and application of histidine dipeptide composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This example provides an animal experiment on the repairing effect of a histidine dipeptide composition on liver function damage in rats with high uric acid.

[0035] (1) Establish an experimental model

[0036]135 male SD rats (200±20g) were randomly divided into 9 groups (blank group, model group, low-dose histidine dipeptide composition group, middle-dose histidine dipeptide composition group, histidine dipeptide Composition high-dose group, anserine group, carnosine group, carnosine + anserine group, river clam, astragalus, pueraria ternary extract group), 15 rats in each group. The composition low-dose group is divided into 3 groups according to the mass ratio, wherein the mass ratios of carnosine, anserine, river clam extract, kudzu root extract, and astragalus extract in these 3 groups are 50:20:5:5: 5. 55:22.5:7.5:7.5:7.5, 60:25:10:10:10; the middle dose group of the composition, the high dose group of the composition and the low dose group of the composition w...

Embodiment 2

[0047] This example provides a clinical trial of the liver repair effect of a histidine dipeptide composition on hepatitis patients.

[0048] (1) Research objects and treatment methods

[0049] According to the classification criteria established by the Council of International Medical Organizations and revised by the Hepatology Branch of the Chinese Medical Association, alanine aminotransferase (ALT) ≥ 3 upper limit of the reference value (ULN), and R[R=(measured value of ALT / ALT ULN) / (ALP measured value / ALPULN)] ≥ 5, select 138 patients with clinical hepatocellular injury treated in Guangdong Medical Affiliated Hospital from March 2020 to January 2021, randomly divided into histidine dipeptide combination treatment Group and placebo group, 69 people in each group, there was no significant difference in demographic and baseline data such as sex ratio, average age, and average course of disease between the two groups. The two groups of patients were treated with routine trea...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of biological medicine, and relates to a histidine dipeptide composition for repairing liver injury, the histidine dipeptide composition comprises the following effective components: carnosine, goose carnosine, corbicula fluminea extract, radix puerariae extract and radix astragali extract, and the mass ratio of the carnosine to the goose carnosine to the corbicula fluminea extract to the radix puerariae extract to the radix astragali extract in the composition is (50-60): (20-25): (5-10): (5-10): (5-10). The histidine dipeptide composition provided by the invention can effectively prevent and / or treat liver injury in a certain proportioning range, especially has excellent effects in repairing liver cell injury, preventing and / or treating liver injury caused by hypeluricemia and treating clinical liver cell injury type liver diseases, and has the advantages of cheap raw materials, simple preparation method, low cost, and no toxic effect.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a histidine dipeptide composition, in particular to a histidine dipeptide composition for repairing liver damage. Background technique [0002] Drug-induced liver injury (Drug-induced Liver Injury DILI) refers to the disease caused by the toxic damage of liver cells caused by drugs or their metabolites or the allergic reaction of the liver to drugs and their metabolites during the treatment of drugs, also known as For drug-induced hepatitis. With the continuous increase of various new drugs in clinical practice, the combined use of multiple drugs, and the wide application of Chinese herbal medicines and Chinese patent medicine preparations, the incidence of drug-induced liver injury is increasing year by year. At the same time, the incidence of liver diseases such as viral hepatitis, liver cirrhosis and liver cancer is relatively high, which has seriously endangered the health of the peo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K31/4172A61P1/16C12P21/06C07K1/34C07K1/16C07K1/14C07K1/36A61K35/618A61K36/481
CPCA61K31/4172A61K35/618A61K36/488A61K36/481A61P1/16C12P21/06C07K1/34C07K1/16C07K1/14C07K1/36A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2236/333A61K2300/00
Inventor 吉宏武陈铭张迪宋文奎苏伟明刘书成
Owner GUANGDONG OCEAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap