Histidine dipeptide composition for repairing liver injury and application of histidine dipeptide composition
A technology of liver injury and peptide composition, applied in the field of histidine dipeptide composition for repairing liver injury, and histidine dipeptide composition, to achieve excellent liver cell damage, reduce liver index, and inhibit liver lipid peroxidation Effect
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Embodiment 1
[0034] This example provides an animal experiment on the repairing effect of a histidine dipeptide composition on liver function damage in rats with high uric acid.
[0035] (1) Establish an experimental model
[0036]135 male SD rats (200±20g) were randomly divided into 9 groups (blank group, model group, low-dose histidine dipeptide composition group, middle-dose histidine dipeptide composition group, histidine dipeptide Composition high-dose group, anserine group, carnosine group, carnosine + anserine group, river clam, astragalus, pueraria ternary extract group), 15 rats in each group. The composition low-dose group is divided into 3 groups according to the mass ratio, wherein the mass ratios of carnosine, anserine, river clam extract, kudzu root extract, and astragalus extract in these 3 groups are 50:20:5:5: 5. 55:22.5:7.5:7.5:7.5, 60:25:10:10:10; the middle dose group of the composition, the high dose group of the composition and the low dose group of the composition w...
Embodiment 2
[0047] This example provides a clinical trial of the liver repair effect of a histidine dipeptide composition on hepatitis patients.
[0048] (1) Research objects and treatment methods
[0049] According to the classification criteria established by the Council of International Medical Organizations and revised by the Hepatology Branch of the Chinese Medical Association, alanine aminotransferase (ALT) ≥ 3 upper limit of the reference value (ULN), and R[R=(measured value of ALT / ALT ULN) / (ALP measured value / ALPULN)] ≥ 5, select 138 patients with clinical hepatocellular injury treated in Guangdong Medical Affiliated Hospital from March 2020 to January 2021, randomly divided into histidine dipeptide combination treatment Group and placebo group, 69 people in each group, there was no significant difference in demographic and baseline data such as sex ratio, average age, and average course of disease between the two groups. The two groups of patients were treated with routine trea...
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