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Application of CPT1A protein in alcoholic acute pancreatitis disease

An acute pancreatitis, alcohol-related technology, applied in the application field of CPT1A protein in alcoholic acute pancreatitis disease, can solve the problems of incompletely clear activation of main signaling pathways of molecular and signaling mechanisms, and hinder understanding of interactions, and achieve the goal of promoting Effects of inflammation

Active Publication Date: 2021-11-05
川北医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the complexity of the interplay between these factors has hampered our understanding of the disease process, and the molecular and signaling mechanisms and activation of major signaling pathways associated with alcoholic acute pancreatitis remain incompletely understood

Method used

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  • Application of CPT1A protein in alcoholic acute pancreatitis disease
  • Application of CPT1A protein in alcoholic acute pancreatitis disease
  • Application of CPT1A protein in alcoholic acute pancreatitis disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] In order to explore the relationship between various proteins and alcoholic acute pancreatitis, especially CPT1A protein, this example provides the screening process of various proteins and uses CPT1A protein as the target protein to verify its promoting effect on alcoholic acute pancreatitis Among them, GCG represents the control group, ACG represents the alcohol control group, GEG represents the pancreatitis group, AEG represents the alcoholic pancreatitis group, INEG represents the inhibitor experimental group, and DGCG represents digalactosyldiacylglycerol digalactosyldiacylglycerol Triols, LPS stands for lysophosphatidylserine, PI stands for phosphatidylinositol, PS stands for phosphatidylserine, MPO stands for serum myeloperoxidase, LY6G stands for neutrophils; the specific process includes the following :

[0031] 1. Experimental animals and breeding

[0032] Experimental animals: male Sprague-Dawley rats (body weight 200-250g) were fed in a room at 22±1°C and s...

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Abstract

The invention discloses application of CPT1A protein in alcoholic acute pancreatitis disease, which belongs to the technical field of functions and applications of proteins. Differential expression protein molecules in the alcoholic acute pancreatitis are analyzed through combination of proteomics and lipid metabonomics, metabolites of the differential expression protein molecules are analyzed at the same time, results show that after the expression of the CPT1A protein is inhibited, the inflammatory response is obviously relieved, so that the CPT1A protein has the effect of promoting inflammation in the alcoholic acute pancreatitis, and a theoretical basis and a clinical basis are provided for researching a new target and a new strategy for preventing and treating the alcoholic acute pancreatitis disease.

Description

technical field [0001] The invention relates to the technical field of protein function and application, in particular to the application of CPT1A protein in alcoholic acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is one of the most common acute abdominal diseases in clinical practice. The incidence rate is increasing year by year, and the mortality rate is maintained at 1% to 2%, 80% of which are mild, and there is no systemic inflammatory response syndrome, distal organ damage or serious complications of severe pancreatitis in the late stage. Gallstones and alcohol factors accounted for 40% and 30% of patients with first-episode acute pancreatitis, respectively. It is worth noting that alcoholism is the most common cause of recurrent acute pancreatitis, accounting for about 57%, much higher than other causes. However, even among individuals who drink heavily, the absolute risk of pancreatitis is very low, estimated by Lankisch et al to be 2–3%...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/72G01N30/89
CPCG01N30/02G01N30/06G01N30/34G01N30/72G01N30/89
Inventor 张小明李增晖曾梅梁蕊蒲宇邓艳杜娟娟张馨予刘威
Owner 川北医学院
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