96 results about "Acute pancreatic inflammation" patented technology

The invention relates generally to methods for treating acute pancreatitis in patients. The methods comprise administering a therapeutically effective amount of a pharmaceutical composition comprising secretin and a pharmaceutically acceptable carrier.

A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from a macrophage wherein said condition is acute pancreatitis. The compounds of the present invention include a quaternary analog of cocaine; (1-aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid 1-(2-fluorophenyl)-ethyl ester; a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), and an oligonucleotide or mimetic capable of attenuating the symptoms of acute pancreatitis wherein the oligonucleotide or mimetic consists essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 cholinergic receptor. The variables of formulae (I), (II), (III) and (IV) are described herein

The invention discloses a test card for rapidly diagnosing pancreatic trauma and acute pancreatitis and a preparation method of the test card. The test card comprises a plastic shell, a bottom lining and detection modules, wherein the plastic shell is provided with a sampling hole and an observation window, and the sampling hole and the observation window are fixed with transparent waterproof films. The bottom lining is provided with multiple longitudinally parallel arranged slots; and the number of the detection modules is consistent to that of the bottom lining, and the detection modules are glued into the slots of the bottom lining. Each detection module comprises chromatographical membranes, combination pads, sample pads, filtration pads and water sucking pads. The chromatographical membranes are provided with test lines and quality control lines, the test lines are TAP (thiamphenicol) polyclonal antibodies, and the quality control lines are covered rabbit anti-mice immune globulin antibodies. The test card for rapidly diagnosing pancreatic trauma provided by the invention is capable of quickly and accurately diagnosing the diseases such as pancreatic trauma and acute pancreatitis, and adding multiple samples simultaneously for positive control and negative control, and has the advantages of being convenient and rapid to detect, high in flexibility and accuracy, stable in property and cheap in cost.

The invention discloses a dried chemical indicator paper to test human alpha-diastatic activity in the external clinical diagnostic agent technical domain, which is composed of long-bar shaped upper and lower support layers, each middle testing layers, wherein the indicator paper is divided into hand-held area and testing area, wherein the testing area is dispersing layer, filter layer and agent layer from upwards to downwards; the dispersing layer is selected from kinds of grid material of synthetic fiber material; the filter layer can be kinds of filter material to filter blood; the agent layer is asymmetrical synthetic film; one sampling hole is opened on the upper support layer for sample to enter the dispersing layer to permeate the filter layer and agent layer and change color at agent layer due to chemical reaction; the testing hole of lower support layer can test the change of optical density in the reacting course. The inveniton can test the human alpha-diastatic activity quantitatively, which provides evidence for acute pancreatitis.

A composition comprising a water-soluble and stable complex formed by an alkyl ether derivative of gamma-cyclodextrin and curcumin and optionally comprising non-complexed cyclodextrin, the molar ratio of curcumin to cyclodextrin being between 1:1 and 1:6, and a method of manufacturing such a composition. The water-soluble and stable complex of curcumin is useful in therapy, e.g. for treatment of cancer, leukemia, myocardial infarction, stroke, sepsis, acute lung injury, acute liver failure, acute tubular necrosis, acute pancreatitis, radiation injury and other life-threatening conditions in a human or animal subject, as well as for preserving human or animal organs, tissues or cells at a hypothermic temperature.

The invention relates to traditional Chinese medicine composition for treating acute pancreatitis. The traditional Chinese medicine composition consists of the following herbal materials in parts by weight: 6-18 parts of radix bupleuri, 6-18 parts of mangnolia officinalis, 5-15 parts of astragalus membranaceus, 5-15 parts of elecampane, 5-15 parts of immature bitter orange, 5-15 parts of szechwan Chinaberry fruit, 5-15 parts of mirabilite, 3-7 parts of coptis chinensis, 3-7 parts of liquorice, 5-15 parts of pinellia ternate, 5-15 parts of rhizoma corydalis, 10-30 parts of semen raphani, 10-30 parts of honeysuckle, 10-30 parts of dandelion, 10-30 parts of betel nuts, 10-30 parts of rheum officinale, 6-12 parts of herba artemisiae capillaries, 6-12 parts of fructus gardeniae, 6-12 parts of gentiana scabra bge and 6-12 parts of fructus forsythiae. The traditional Chinese medicine composition has the efficacies of clearing heat and drying dampness, promoting the circulation of qi to conduct stagnation, removing food retention to removing flatulence, and soothing the liver and purging intense heat, has an obvious curative effect on the treatment of the acute pancreatitis, is reliable in function, wide in component medicinal herbs resources, and simple and convenient to prepare and does not have toxic and side effect.

Disclosed is an oral administration Chinese medicament for treating acute pancreatitis, wherein the medicament is prepared from the following raw materials (by weight portion): sargentgloryvine stem, herba patriniae each 25-30g, haw 13-15g, citrus auranlium 10-12g and rhubarb horsetails 8-10g. The invention realizes easy material availability, simplified preparation, low cost, and quick effect.

A nutritive medicine containing important intra-intestinal nutrients for treating acute pancreatitis and the dangerous patients is an improvement on existing one in such areas that using malt dextrin to decrease the ratio of carbohydrate, increasing the ratios of medium-chain fatty acids and non-saturated monofatty acid, and additionally using probotics and some rare elements.

The invention discloses a traditional Chinese medicine composition for treating acute pancreatitis, which comprises the following raw materials in parts by weight: 10-15 parts of raw rhubarb, 10-15 parts of coptis root, 6-8 parts of rhizoma corydalis, 3-5 parts of dandelion, 1-2 parts of Korean ginseng, 3-5 parts of Chinese angelica, 2-4 parts of radix linderae, 1-3 parts of pericarpium citri reticulatae viride, 5-7 parts of anemone dichotoma, 4-6 parts of prepared frankincense, 2-4 parts of rhizoma paridis, 5-8 parts of Sichuan lovage rhizome, 3-5 parts of waxgourd peel, 8-10 parts of lalang grass rhizome, 2-4 parts of polygonum posumbu, 6-8 parts of semen coicis and 2-4 parts of herba patriniae. The traditional Chinese medicine composition has effects of strengthening a spleen, tonifying a lung, soothing a liver, resolving depression, promoting blood circulation to remove blood stasis, clearing away heat and drying dampness, has a significant curative effect of treating the acute pancreatitis, functions reliably, is wide in component source, and simple and convenient to prepare, and has no toxic or side effects.

The invention discloses application of parthenolide as a platelet-activating factor (PAF) inhibitor. The parthenolide can be used as a safe PAF antagonist to be applied to treatment, auxiliary treatment and prevention of diseases such as thrombus, atherosclerosis, ischemic cardio-vascular disease, cerebral ischemia, acute pancreatitis, endotoxic shock, asthma, hepatic fibrosis and hepatocirrhosis, injury of nerve, gastrointestinal ulcer and necrosis, psoriasis, systemic lupus erythematosus and acquired immune deficiency syndrome related to platelet-activating factor.

The invention relates to a Chinese medicinal composition for treating acute pancreatitis, which consists of the following Chinese medicinal raw materials in parts by weight: 10 to 30 parts of astragalus, 10 to 30 parts of codonopsis pilosula, 10 to 30 parts of roasted bighead atractylodes rhizome, 20 to 40 parts of coix seed, 10 to 30 parts of white peony root, 10 to 30 parts of red peony root, 10 to 20 parts of radix bupleuri, 10 to 20 parts of fructus amomi, 10 to 20 parts of herba lycopi, 10 to 20 parts of gizzard-membrane, 10 to 20 parts of radix curcumae, 5 to 15 parts of immature bitter orange, 5 to 15 parts of liquorice, 10 to 20 parts of abrus cantoniensis hance, and 10 to 20 parts of sedum sarmentosum. The Chinese medicinal composition has the functions of strengthening spleen and tonifying lung, soothing liver-qi stagnation, activating blood and removing stasis, and clearing heat and drying dampness, has the advantages of remarkable curative effect and reliable effect in treating acute pancreatitis, is wide in medicinal component source and easy to prepare, and does not have toxic or side effect.

The invention relates to a Chinese medicament for treating acute adenitis, which is prepared from Bulbus Allii Macrostemonis 6g, birthwor root 7g, fruit of citron 7g, magnolia bark 9g, cyperus rotundus 9g, curcuma longa 6g, capsule of weeping forsythia 9g, earthworm 8g, radix scrophulariae 9g, processed pinellia tuber 6g, wrinkled gianthyssop 9g, rhubarb horsetails 9g, coptis root 5g, sodium sulfate 7g and licorice root 3g.

The invention discloses a traditional Chinese medicine composition for treating acute pancreatitis, which comprises the following raw materials by weight: 5-10 parts of rheum officinale, 5-10 parts of saltcake, 6-12 parts of bitter orange, 9-15 parts of magnolia cortex, 5-10 parts of red sage root, 5-10 parts of ligustrazine, 5-10 parts of breviscapinun, 5-10 parts of Artemisia capillaries, 5-10 parts of gentrin knotweed, 10-20 parts of radix bupleuri, 10-20 parts of gentian, 10-20 parts of pinellia ternate, 5-10 parts of white peony root, 2-6 parts of root of large-flowered skullcap, 2-6 parts of cape jasmine, 5-10 parts of ginkgo biloba, 2-6 parts of acanthopanax and 2-6 parts of rutin. According to the traditional Chinese medicine composition, the selected raw materials are natural, the compatibility is scientific, the ache can be quickly relieved, the abdominal distension is eliminated, the inflammation is reduced, the traditional Chinese medicine composition has obvious curative effect for treating pancreatitis, no toxic and side effect can be generated, the clinical practice verifies that the treatment effect is obvious, the mortality is greatly reduced, and the cure rate is enhanced.

The invention relates generally to methods for treating acute pancreatitis in patients. The methods comprise administering a therapeutically effective amount of a pharmaceutical composition comprising secretin and a pharmaceutically acceptable carrier.

The invention discloses a Chinese herbal preparation for treating severe acute pancreatitis. According to the traditional Chinese medicine, the pathogenesis of the severe acute pancreatitis is due to lacking of soothing of the liver and gall and accumulation of damp and hot, flaming heat toxin and blocking stagnant heat inside are further developed, then the lung is compressed, or the pericardium is invaginated, or the blood network vessel is thermally burnt to cause the severe acute pancreatitis. The key of the pathogenesis is excess heat and blood stasis. Therefore, the Chinese herbal medicines of caesalpinia minax hance, glabrous sarcandra herb, souliea vaginata, Wilson barberry, abrus cantoniensis hance, desmodium styracifolium, all grass or root of tricarinate calanthe, rubus alceaefolius poir, polygonum cuspidatum, root of procumbent urena, and pericarpium citri reticulatae viride are chosen and decocted with water to prepare a decoction of herbal medicine; the clinical test in the hospital shows that the total effective rate is up to 96.9%, and the occurrence rate of complications is remarkably lower than that of a contrast group.

The invention provides a traditional Chinese medicine composition for treating acute pancreatitis, which is composed of rhubarb, citrus aurantii, magnolia officinalis, mirabilite, scutellaria baicalensis, phellodendron phellodendron, and Bupleurum chinensis. .

The invention relates to a medicine composition for treating acute or chronic cholecystitis and acute or chronic pancreatitis, which belongs to the field of Chinese medicines and is prepared by saikosaponin 8-15 parts, baicalin 5-12 parts, magnolol 7-16 parts, rheum emodin 1-5 parts, immature total bitter orange flavonoid 9-18 parts, caffeic acid 8-16 parts, paeoniflorin 7-13 parts, chlorogenic acid 10-17 parts, rhizoma pinellinae praeparata 7-13 parts and glycyrrhizic acid 2-7 parts. The medicine composition for treating acute or chronic cholecystitis and acute or chronic pancreatitis has the advantages that the medicine has anti-inflammation, analgesia and antibacterium functions according to Chinese medicine theories and modern pharmacological experimental methods, has a main function of cleaning and discharging liver-gallbladder damp and heat, and is used for acute or chronic cholecystitis and acute or chronic pancreatitis.

The invention discloses a total RNA extracting method of pancreatic tissue of acute pancreatic disease animal, which comprises the following steps: preparing lavage liquid; breeding film after degerming for 2h in the 95% O2 and 5% CO2; narcotizing the ill animal; plugging pipe into main pancreatic duct from the opening of duodenum; injecting fitful quantity of lavage liquid; cutting the pancreatic tissue; pruning in the soy parenzyme inhibitor under 4 deg. c; washing; placing in the TRlzol cracking liquid to homogenize at 4 deg. c; extracting the total RNA of pancreatic tissue according to the instruction of TRlzol cracking liquid agent box; detecting the density and the rate of OD260 and OD280 through spectrophotometric method; estimating the density; identifying the completeness integrity through 1% agarose gel electrophoresis.

The invention provides a drug composition for treating acute pancreatitis and application thereof. The composition comprises a fibroblast growth factor 21 (FGF 21), and the fibroblast growth factor 21is used individually or is jointly used with other accessories as an active ingredient. The fibroblast growth factor 21 or the drug composition containing the fibroblast growth factor 21 can be usedfor treating acute pancreatitis, does not antagonize functions of other members of FGF family, and the use safety is very high.

The invention discloses application of berberine or other pharmaceutically acceptable salts in preparing a M3 receptor selective inhibitor medicine. The medicine is used for treating acute pancreatitis, lung cancers and colon cancers, self-immunity sialadenitis, asthma, respiratory tract inflammation, lung diseases and cardiovascular diseases, relieving panic, or treating excessive activity of bladders, and is used for inhibiting the enhancing of Ca<2+> signals in pancreatic acinar cells caused by M3 receptor-mediated acetyl choline and L-arginine.

Disclosed is a method for treating acute pancreatitis in a subject. The method comprises the step of administering to the subject an effective amount of an ester of an alpha-ketoalkanoic acid or an amide of an alpha-ketoalkanoic acid.

The invention provides a construction method of an acute pancreatitis animal model. According to the construction method, high-fat feed and alcohol are used for jointly inducing animals to form acute pancreatitis. Obesity caused by high-fat feed and alcohol can synergistically cause pathological damage to pancreas of mice, local inflammatory response of pancreas and inflammatory response of lungs and the whole body. In a basic obesity state, the morbidity condition of a large amount of alcohol drinking of the animal model is closer to human morbidity, pancreatic injury is obvious and accompanied by multiple organ dysfunction syndromes, and the animal model accords with the clinical characteristic that obese acute pancreatitis patients are prone to severe illness. The animal model is simple in modeling method, good in repeatability and high in clinical correlation, the model can be used for studying the pathogenesis of obesity and alcohol-related acute pancreatitis, and an important basis is provided for screening treatment targets and studying medical transformation.

The invention discloses a traditional Chinese medicine composition for treating acute pancreatitis. The composition is composed of following raw materials in parts by weight: 10 to 12 parts of rheum officinale, 5 to 8 parts of red sage root, 2 to 4 parts of banksia rose, 1 to 3 parts of coptis, 3 to 5 parts of licorice, 2 to 4 parts of pinellia ternate, 5 to 7 parts of rhizoma corydalis, 3 to 5 parts of radish seed, 8 to 10 parts of bitter orange, 2 to 4 parts of dandelion, 5 to 7 parts of corydalis tuber, 3 to 5 parts of desmodium, 2 to 4 parts of cordate houttuynia, 5 to 7 parts of gentian, 2 to 4 parts of sunflower floral disc, 5 to 7 parts of chicken's gizzard membrane, 3 to 5 parts of buckwheat, 6 to 8 parts of Chinese waxgourd peel, 10 to 15 parts of imperata rhizome, 2 to 4 parts of kalimeris indica, 1 to 3 parts of physalis peruviana, 1 to 3 parts of turnjujube tree root, 4 to 6 parts of mussel, and 2 to 4 parts of acorus gramineus. The traditional Chinese medicine has the functions of calming the liver, subduing yang, nourishing blood, restraining yin, clearing heat, drying dampness, tonifying qi, and securing the exterior, and has the advantages of low cost, definite curative effect, and no toxic or side effect.

The invention relates to a medicine treating pancreatitis, which comprises the following components by weight percent: 10-30 brooklet anemone root, 5-15 dried ginger, 10-30 rhizoma arisaematis, 10-30 gentian, 10-30 purple bergenia, 10-30 knotweed rhizome and 10-30 giant knotweed rhizome. The invention has special efficacy on treating acute pancreatitis. The common patient can be cured after three-day administration and does not need operation. The pain and treatment expense of the patients is reduced. The invention has good treatment effect for the chronic pancreatitis, the treatment time is short and the treatment expense is low. The invention also has good efficacy for cholecystitis and digestive system diseases.

The invention discloses a traditional Chinese medicine composition for treating acute pancreatitis. The composition is prepared from the following raw materials in parts by weight: 10 to 15 parts of fructus forsythiae, 5 to 10 parts of radix paeoniae alba, 8 to 12 parts of moutan bark, 10 to 15 parts of honeysuckle, 12 to 18 parts of fructus aurantii, 7 to 14 parts of radix curcumae, 5 to 10 parts of radish leaves, 15 to 20 parts of radix scutellariae, 4 to 8 parts of flower bud of Japanese apricot, 6 to 12 parts of radix aucklandiae, 10 to 15 parts of the root of Chinese thorowax, 5 to 10 parts of pericarpium canavaliae, 16 to 22 parts of longhairy antenoron herb, 12 to 18 parts of common bombax flower, 5 to 10 parts of sea blubber skin, 10 to 15 parts of ligusticum wallichii, 3 to 7 parts of loofah sponge, 5 to 10 parts of semen citri reticulatae, 13 to 19 parts of paederia scandens and 10 to 15 parts of peach kernels. The composition is scientific and reasonable in formula and has the functions of clearing heat to resolve depression, nourishing the liver to smooth qi and promoting blood circulation to arrest pain under the mutual synergy of all the components, thereby having very obvious effects for treating the acute pancreatitis. The composition is rapid in efficacy, short in treatment course as well as obvious in treatment effect and cannot generate toxic side effects and adverse reactions after being taken by a patient. The cure rate of the composition reaches more than 88%; the total effective rate of the composition reaches more than 95%.

The invention discloses effect of long-chain inulin in adjusting acute pancreatitis and related tissue damage caused thereby, and belongs to the technical field of prevention and treatment of acute pancreatitis. It is verified herein that long-chain inulin can protect from caerulein-induced acute pancreatitis in mice and may be added, as an effective ingredient, to drugs for preventing and treating acute pancreatitis, thereby reducing occurrence and progress and degree of clinical acute pancreatitis. The long-chain inulin is used to carry out preventive treatment for a caerulein-induced mice acute pancreatitis model, pathomorphologic observation is carried out on pancreatic tissues of mice, the levels of serum pancrelipase, serum amylase and tissue inflammatory cell liberase in mice are measured, anti-inflammatory cytokine IL10 and pro-inflammatory cytokine TNF-Alpha and IL1 Beta in tissues and serum are also measured. By comparing index levels of mice in an insulin treatment group and an inflammatory model group, the indexes of mice in the inulin treatment group are significantly better those of the inflammatory model group.

The invention discloses a preparation method of a traditional Chinese medicine for treating acute pancreatitis caused by engorgement, belonging to the technical field of preparation methods of traditional Chinese medicines. At present, sulfonamides and antibiotics are usually used for treating acute pancreatitis caused by engorgement, but gastrointestinal tract reaction, crystalluria, hematuresis, erythra, drug fever and leukopenia are caused by sulfamethoxazole in patients sometime. The preparation method comprises the steps of: placing radish seed, papaw, fleurdelis, carrot, buckwheat, medicated leaven, quince, clove, akebia trifoliata koidz, Chinese anise, common jasminorange leaf and twig, aspongopus, semen canavaliae, elecampane inula root, szechwan Chinaberry fruit, caesalpinia sepiaria, three-nerved spicebush root, nardostachyos root and rhizome, ambergris, greater celandine herb, longpeduncle kadsura root, China fir, bergarmot, costustoot and licorice root into water for soaking; then decocting with slow fire; and filtering to remove residues to obtain a decoction, i.e., the traditional Chinese medicine for treating acute pancreatitis caused by engorgement. The preparation method is simple; and the traditional Chinese medicine has the advantages of little toxic and side effects, short treatment course and high cure rate, and can also avoid adverse effects generated by application of Western medicines.

The invention discloses a compound traditional Chinese medicine aqueous extract for treating acute pancreatitis. The preparation raw materials of compound traditional Chinese medicine aqueous extract for treating acute pancreatitis comprise, by weight, 22-27 parts of gardenias, 22-27 parts of cortex moutan, 22-27 parts of costusroots, 22-27 parts of cortex magnoliae officinalis, 22-27 parts of corydalis yanhusuo, 35-45 parts of red peony roots, 35-45 parts of rhubarb and 12-17 parts of mirabilite. According to the compound traditional Chinese medicine aqueous extract for treating acute pancreatitis, eight traditional Chinese medicine compounds are selected to be used as the preparation raw materials. The aqueous extract obtained through preparation is applied to drugs for treating acute pancreatitis. As is proved by the experiment of the prepared drug, abdominal distension and intestinal paralysis can be remarkably relieved during severe acute pancreatitis (SAP), and therefore SAP symptoms can be remarkably relieved. Complications are reduced, and the death rate is reduced. According to treatment and summaries on more than 5000 cases of acute pancreatitis patients and more than 1000 cases of SAP patients, a good curative effect is achieved, the SAP cure rate can reach 85.4%, and the death rate is reduced to 10.1%. The source of the materials of the compound traditional Chinese medicine aqueous extract for treating acute pancreatitis is wide, the materials can be obtained easily, and cost is low. The adopted preparation method is simple and easy to implement and facilitates industrialization.

A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from a macrophage wherein said condition is acute pancreatitis. The compounds of the present invention include a quaternary analog of cocaine; (1-aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid 1-(2-fluorophenyl)-ethyl ester; a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), and an oligonucleotide or mimetic capable of attenuating the symptoms of acute pancreatitis wherein the oligonucleotide or mimetic consists essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 cholinergic receptor. The variables of formulae (I), (II), (III) and (IV) are described herein.