Quaternary ammonium salt complex iodine disinfectant and preparation method thereof

The technology of a disinfectant and a quaternary ammonium salt is applied in the field of quaternary ammonium salt complexed iodine disinfectant and its preparation, and can solve the problems of affecting the sterilization effect of the quaternary ammonium salt complexed iodine, volatile iodine, and easy precipitation of iodine, etc. Achieve the effect of fast disinfection and sterilization, long duration of sterilization and bacteriostasis, and extended validity period

Active Publication Date: 2021-11-12
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently commercially available quaternary ammonium salt complexed iodine products generally have some problems, such as poor stability, easy precipitation of iodine simple substance during normal temperature or refrigerated storage, and high temperature storage of iodine simple substance is easy to volatilize, resulting in a rapid decline in iodine content and affecting the complexation of quaternary ammonium salts. The bactericidal effect of iodine; the quaternary ammonium salt itself is easily disturbed by organic matter in the environment, which affects its bactericidal effect, etc.

Method used

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  • Quaternary ammonium salt complex iodine disinfectant and preparation method thereof
  • Quaternary ammonium salt complex iodine disinfectant and preparation method thereof
  • Quaternary ammonium salt complex iodine disinfectant and preparation method thereof

Examples

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Effect test

Embodiment 1

[0024] The preparation of quaternary ammonium complex iodine disinfectant comprises the steps:

[0025] (1) Put 400 mL of absolute ethanol in a reactor with a reflux condenser, stir, and control the temperature at 50°C, then put 20 g of decyl ammonium bromide and 20 g of decyl ammonium chloride into the reactor, and stir until the reaction liquid After becoming transparent, add 10g of elemental iodine, dropwise add 70g of isooctyl alcohol polyoxyethylene ether JFC-E, then raise the temperature to 85°C, and wait for 2-3 hours until the reaction solution becomes transparent.

[0026] (2) Lower the temperature of the above reaction system to 60°C, add 1 g of potassium iodide into the reactor, stir until the reaction solution becomes transparent, then remove the solvent ethanol by rotary evaporation under reduced pressure, cool down, let stand, and discharge to obtain the product.

Embodiment 2

[0028] The preparation of quaternary ammonium complex iodine disinfectant comprises the steps:

[0029] (1) Put 180mL of absolute ethanol in a reactor with a reflux condenser, stir, and control the temperature at 40°C, then add 7.5g of benzalkonium bromide and 7.5g of bis-octyldimethylammonium chloride In the reactor, after stirring until the reaction liquid is transparent, add 3 g of elemental iodine, dropwise add 45 g of isooctyl alcohol polyoxyethylene ether JFC-E, and then raise the temperature to 80°C for 2-3 hours until the reaction liquid is transparent.

[0030] (2) Lower the temperature of the above reaction system to 50°C, add 0.1g of potassium iodate and 0.1g of citric acid into the reactor, stir until the reaction solution is transparent, then remove the solvent ethanol by rotary evaporation under reduced pressure, after cooling, let stand , out of the box.

Embodiment 3

[0032] The preparation of quaternary ammonium complex iodine disinfectant comprises the steps:

[0033] (1) Put 200mL of absolute ethanol in a reactor with a reflux condenser, stir, and control the temperature at 45°C, then put 10g of decylmethylammonium bromide and 10g of bis-octyldimethylammonium chloride into the reactor , stir until the reaction liquid is transparent, add 4g of elemental iodine, dropwise add fatty alcohol polyoxyethylene ether AEO-955g, then raise the temperature to 80°C, and wait for 2-3 hours until the reaction liquid is transparent.

[0034] (2) Lower the temperature of the above reaction system to 55°C, add 0.2 g of potassium iodide and 0.2 g of citric acid into the reactor, stir until the reaction solution is transparent, then remove the solvent ethanol by rotary evaporation under reduced pressure, after cooling, let stand, and You get it right away.

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Abstract

The invention relates to a quaternary ammonium salt complex iodine disinfectant and a preparation method thereof. The disinfectant comprises the following components in percentage by weight: 18-35% of quaternary ammonium salt, 55-78% of an auxiliary surfactant, 4-10% of iodine and 0.18-0.85% of a stabilizer. The disinfectant is simple in preparation process, easy to control, short in production period, low in cost and suitable for industrial production. The prepared disinfectant is high in stability, high in iodine content, long in bacteriostasis and sterilization time, high in sterilization speed and high in efficiency, can be widely applied to disinfection and sterilization of livestock and poultry farms, can also be used as a local preservative used before a surgical operation, and can be applied to the aspects of treatment of slight cuts, bruises, nipple sores and scratches, breast medicated bath and the like.

Description

technical field [0001] The invention belongs to the technical field of disinfectants, and in particular relates to a quaternary ammonium salt complexed iodine disinfectant and a preparation method thereof. Background technique [0002] In 1915, Jacobs reported the synthesis of quaternary ammonium salt disinfectants, and conducted research on sterilization, pointing out that this type of disinfectant has a certain bactericidal ability, which opened the history of quaternary ammonium salt disinfectants. In 1935, German Domagk studied the relationship between the bactericidal performance and chemical structure of this type of disinfectant and the bacteriostasis, which aroused great interest. In the same year, Wetzel was used in clinical disinfection practice and was gradually promoted. It was widely used in skin and mucous membrane disinfection in hospitals, surgical hand washing disinfection and medical equipment disinfection. Mildew prevention of products and agricultural cr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/12A01P1/00A01N33/12A01N25/30A01N25/22A61K31/14A61K33/18A61K47/10A61K9/08A61P31/02A61P17/02
CPCA01N59/12A01N33/12A01N25/30A01N25/22A61K31/14A61K33/18A61K47/10A61K9/08A61P31/02A61P17/02A61K2300/00Y02A50/30
Inventor 廉玉韩刘爱玲李守军李亚玲吴燕子
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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