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Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease

A fatty liver disease, non-alcoholic technology, used in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as incomplete molecular mechanisms

Inactive Publication Date: 2021-11-12
SHIHEZI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mildest stage of NAFLD is hepatic steatosis caused by massive accumulation of fat in the liver. If not properly controlled, it will gradually develop into non-alcoholic steatohepatitis (NASH), fibrosis, hepatitis, and even liver cancer. However, it will lead to the occurrence and development of NAFLD The molecular mechanism of NAFLD is still not completely clear, and there is no officially approved drug in the treatment of NAFLD. It is imminent to research and develop new drugs for the treatment of NAFLD.

Method used

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  • Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease
  • Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease
  • Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease

Examples

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Comparison scheme
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Embodiment Construction

[0018] Further detailed explanation through specific implementation mode below:

[0019] The proportioning ratio of this Chinese medicine composition is shown in the following table:

[0020] turmeric rhubarb Silkworm Jiaogulan Atractylodes Pueraria lotus leaf Alisma Danshen Knotweed leech lapis lazuli licorice Example 1 5 5 8 5 8 8 4 5 5 10 2 8 2 Example 2 30 30 50 20 30 20 50 20 30 20 5 20 20 Example 3 12 9 10 10 10 10 10 10 10 15 3 10 6 Comparative example 1 12 9 10 10 10 10 10 10 0 15 3 10 3 Comparative example 2 12 9 10 10 10 10 10 10 10 15 3 10 1 Comparative example 3 12 9 10 10 10 10 10 10 10 15 3 10 30

[0021] The above-mentioned examples and comparative examples all use the same batch of raw materials under the same environment, and carry out the proportioning strictly according to the single variable method. The specific...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating non-alcoholic fatty liver disease. The traditional Chinese medicine composition is prepared from the following raw material extracts in parts by mass: 10-20 parts of turmeric, 1-10 parts of rheum officinale, 1-20 parts of stiff silkworm, 1-30 parts of gynostemma pentaphylla, 5-30 parts of bighead atractylodes rhizome, 8-20 parts of kudzuvine root, 1-50 parts of lotus leaf, 1-10 parts of rhizoma alismatis, 1-10 parts of salvia miltiorrhiza, 8-20 parts of polygonum cuspidatum, 1-3 parts of leech, 1-10 parts of lapis chloriti and 1-20 parts of liquorice. According to the scheme of the traditional Chinese medicine composition for treating non-alcoholic fatty liver disease, the levels of blood lipid cholesterol (T-CHO), triglyceride (TG) and low-density lipoprotein (LDL-C) of a mouse with the non-alcoholic fatty liver can be effectively reduced, the level of high-density lipoprotein (HDL-C) can be increased, the pathological change of the liver of a model animal with the non-alcoholic fatty liver can be relieved, and a good curative effect can be achieved in clinical observation.

Description

technical field [0001] The solution belongs to the field of traditional Chinese medicines, and specifically relates to a traditional Chinese medicine composition for treating nonalcoholic fatty liver disease. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that causes various pathological effects, such as nonalcoholic steatohepatitis and cirrhosis, insulin resistance, obesity, hypertension, dyslipidemia, diabetes and heart disease. Vascular disease. The mildest stage of NAFLD is hepatic steatosis caused by massive accumulation of fat in the liver. If not properly controlled, it will gradually develop into non-alcoholic steatohepatitis (NASH), fibrosis, hepatitis, and even liver cancer. However, it will lead to the occurrence and development of NAFLD The molecular mechanism of NAFLD is still not completely clear, and there is no officially approved drug in the treatment of NAFLD at present, and it is imminent to resear...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/16A61K35/64A61K35/62A61K33/26
CPCA61K36/9066A61K36/708A61K35/64A61K36/424A61K36/284A61K36/488A61K36/62A61K36/884A61K36/537A61K36/704A61K35/62A61K33/26A61K36/484A61P1/16A61K2236/331A61K2300/00
Inventor 秦冬梅袁今奇李聪邹楠苏林洁
Owner SHIHEZI UNIVERSITY