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Copper-based nano photo-thermal material, preparation method thereof and application of copper-based nano photo-thermal material in cancer treatment

A nano-optical and thermal material technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problem that the therapeutic effect of combined therapy needs to be improved.

Pending Publication Date: 2021-11-12
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the therapeutic effect of existing combination therapy needs to be improved

Method used

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  • Copper-based nano photo-thermal material, preparation method thereof and application of copper-based nano photo-thermal material in cancer treatment
  • Copper-based nano photo-thermal material, preparation method thereof and application of copper-based nano photo-thermal material in cancer treatment
  • Copper-based nano photo-thermal material, preparation method thereof and application of copper-based nano photo-thermal material in cancer treatment

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Experimental program
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Effect test

Embodiment 1

[0048] Nano Copper photothermal materials, preparation method of the present embodiment is as follows:

[0049] (1) Preparation of selenium nanospheres:

[0050] 1mL at a concentration of 0.3mM and selenite were added 60mg polyvinylpyrrolidone 10mL water. Then a magnetic stirring was added 0.115mL of hydrazine monohydrate. After 3h the reaction liquid separation, the resulting solid, a selenium nano ball, and the TEM image thereof as UV-vis spectroscopy figure 2 Shown (left and right respectively). Selenium nanospheres were collected and dispersed to form a dispersion of selenium nanospheres in water for further use.

[0051] (2) copper selenide nano ellipsoid prepared:

[0052] The 1mL at a concentration of 1mg / mL of selenium nanospheres with 1mL of solution of polyvinylpyrrolidone (PVP solution i.e., at a concentration of 10mg / mL) were mixed and then the CuCl 500μL 2 After (0.1M) and 2mL of AA (0.1M) were added to the solution and the mixture was stirred for 5min, the 50μL H...

Embodiment 2

[0057] Example MG63 osteosarcoma cell culture simulation body according to the present embodiment, the method is as follows: MG63 cell is a cell line derived from a human osteosarcoma were cultured in DMEM medium supplemented with 10% fetal bovine serum (FBS) and 1% antibiotics (penicillin / streptomycin). The cells 37 ℃, containing 5vol% CO 2 Cultivation of a humid atmosphere.

Embodiment 3

[0059] Nano Copper detection photothermal material obtained biological toxicity of MG63 cells, as follows:

[0060] Membrane structural damage caused by apoptosis or necrosis of cells will result in the cytoplasm of lactate dehydrogenase (LDH) released into the medium. Thus, we can analyze quantitatively the cytotoxic activity of LDH released into the medium by detecting.

[0061] In this invention:

[0062] ① The MG63 cells were seeded into 96-well plates, allowed growth after 24h, added with different concentrations of Cu 2-x Se @ PDA @ AIPH and incubated for 14h.

[0063] ② The cells with lasers 1W / cm 2 Processing power density 5min, then the medium infrared camera temperature was controlled at 45 ℃.

[0064] ③ The cells were incubated at 37 [deg.] C 10h.

[0065] A kit to assess the activity of LDH released in the medium was determined by LDH Cytotoxicity ④.

[0066] In order to quantitatively evaluate Cu2-x The toxicity of SE @ PDA @ AIPH, we analyzed the activity of lactat...

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to a copper-based nano photo-thermal material, a preparation method thereof and application of the copper-based nano photo-thermal material in cancer treatment. The photo-thermal material is of a core-shell structure formed by wrapping a copper selenide nano ellipsoid with a coating layer formed by polydopamine and AIPH. The photo-thermal material disclosed by the invention has a good photo-thermal effect and controllable release performance of oxygen free radicals at tumor sites, can greatly improve the treatment effect, and can be used for combined treatment of cancers.

Description

Technical field [0001] The present invention belongs to the field of biomedical materials, and more particularly to a copper-based nano-optic thermal material and a preparation method thereof, and the application of cancer treatment. Background technique [0002] In recent years, the photothermal therapy (PTT) has been a wide concern in the advantage of a new type of efficient treatment of cancer technology. The essence is a material having a photothermal conversion efficiency, and the material is converted to thermal energy in the tumor portion in the tumor portion, and kills cancer cells using high temperatures. At the same time, chemotherapy is also a clinically important cancer treatment. However, due to optical scattering and absorption effects in tumor tissues, individual photothermal treatment often cannot completely eradicate tumors. Chemotherapy is a treatment method for the ultimate killing cancer cells such as the use of chemical drugs to prevent the value added, invas...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/34A61K47/22A61P35/00B82Y5/00B82Y30/00B82Y40/00
CPCA61K41/0052A61K9/5146A61K9/5123A61K9/0019A61P35/00B82Y5/00B82Y30/00B82Y40/00
Inventor 张肖婷程浩艳胡浩
Owner HENAN UNIV OF SCI & TECH
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