Composite nanoparticle with photoacoustic development and photothermal therapy functions

A composite nanoparticle and photothermal therapy technology, which is applied to medical preparations containing active ingredients, wave energy or particle radiation treatment materials, drug combinations, etc., can solve the problems of poor tumor ablation effect and insufficient photothermal conversion efficiency, etc. Achieve the effects of improving the photoresponse rate, significant photothermal conversion efficiency, and simple preparation process

Active Publication Date: 2021-03-09
WEST CHINA HOSPITAL SICHUAN UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through the above analysis, the problems and defects of the existing technology are: the existing materials used for photothermal therapy have insufficient photothermal conversion efficiency, resulting in poor tumor ablation effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composite nanoparticle with photoacoustic development and photothermal therapy functions
  • Composite nanoparticle with photoacoustic development and photothermal therapy functions
  • Composite nanoparticle with photoacoustic development and photothermal therapy functions

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] Such as figure 1 As shown, the preparation method of composite nanoparticles with photoacoustic imaging and photothermal therapy functions provided by the embodiments of the present invention includes the following steps:

[0052] S101, use 3-5 parts of copper chloride, 1-3 parts of copper sulfide and deionized water to prepare copper chloride solution and sodium sulfide solution respectively, and mix the prepared solutions evenly; add 6-10 parts of transparent Hyaluronic acid HA, 1-2 parts of trisodium citrate, 3-5 parts of ammonium persulfate to prepare HA-CuS nanoparticles;

[0053] S102, placing 4-5 parts of graphite in a reaction container, adding a strong acid and a strong oxidant, introducing ultraviolet light to irradiate the mixed reaction solution to generate graphene oxide;

[0054] S103, using Milli Q water to clean the generated graphene oxide, using the cleaned graphene oxide to prepare graphene quantum dots, and using a molecular sieve separation method ...

Embodiment 1

[0090] Add copper chloride solution, sodium sulfide solution, trisodium citrate and ammonium persulfate to hyaluronic acid (HA) to prepare HA-CuS nanoparticles;

[0091] Put graphite in a reaction vessel, add strong acid and strong oxidant, introduce ultraviolet light into the reaction vessel for irradiation to generate graphene oxide; use clean water to clean graphene oxide, use graphene oxide to prepare graphene quantum dots and It is purified to obtain purified graphene quantum dots (GQDs); N,N'-dicyclohexylcarbodiimide (DCC) is dissolved in N-hydroxysuccinimide (NHS) to obtain active esters, Surface activation of the purified graphene quantum dots was performed using active esters; adding amino polyethylene glycol amino (NH 2 -PEG-NH 2 ), modify PEG molecules on graphene quantum dots to obtain GQDs-PEG; use pyrrole and paraformaldehyde to prepare porphyrin molecules, mix porphyrin molecules with GQDs-PEG, and obtain GQDs-PEG-P after purification.

Embodiment 2

[0093] GODs-PEG-P was coupled on the surface of HA-CuS nanoparticles to obtain composite nanoparticles with photoacoustic imaging and photothermal therapy functions.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of nanoparticle preparation, and discloses a composite nanoparticle with photoacoustic development and photothermal therapy functions. The composite nanoparticles with the photoacoustic development and photothermal therapy functions are formed by coupling graphene quantum dots (GQDs) of surface-PEGylated composite porphyrin molecules and copper sulfidenanoparticles (CuS) modified with hyaluronic acid on the surface. According to the preparation method, GQDs-PEG-P is coupled to the surfaces of the HA-CuS nanoparticles, so that the composite nanoparticles with the photoacoustic development and photothermal therapy functions are obtained. The composite nanoparticles with the photoacoustic development and photothermal therapy functions has the characteristics of good biocompatibility, remarkable photothermal conversion efficiency, excellent photostability and the like, can realize multiple functions of biosensing and tumor diagnosis and treatment, and is beneficial to practical application; and besides, the preparation process is simple, green and pollution-free, and can be popularized and used.

Description

technical field [0001] The invention belongs to the technical field of nanoparticle preparation, and in particular relates to a composite nanoparticle with photoacoustic imaging and photothermal treatment functions. Background technique [0002] At present: Cancer has become one of the most important diseases threatening human health. About 8.8 million people die from cancer every year in the world, and more than 14 million new cancer cases occur. At present, the main means of clinical cancer treatment include surgical resection and chemotherapy. However, for many diffuse and invasive malignant tumors, surgical resection cannot completely eliminate tumor cells, and the possibility of recurrence is high; and chemotherapy drugs often have many side effects, such as nephrotoxicity and neurotoxicity. Near-infrared photothermal therapy is a treatment method that converts light energy into heat energy to kill tumor cells under the irradiation of near-infrared light after material...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K41/00A61P35/00
CPCA61K49/225A61K41/0052A61P35/00
Inventor 吴敏王丹
Owner WEST CHINA HOSPITAL SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap