Composite nanoparticle with photoacoustic development and photothermal therapy functions

A composite nanoparticle and photothermal therapy technology, which is applied to medical preparations containing active ingredients, wave energy or particle radiation treatment materials, drug combinations, etc., can solve the problems of poor tumor ablation effect and insufficient photothermal conversion efficiency, etc. Achieve the effects of improving the photoresponse rate, significant photothermal conversion efficiency, and simple preparation process
CN112451685AActive Publication Date: 2021-03-09WEST CHINA HOSPITAL SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
WEST CHINA HOSPITAL SICHUAN UNIV
Publication Date
2021-03-09

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Abstract

The invention belongs to the technical field of nanoparticle preparation, and discloses a composite nanoparticle with photoacoustic development and photothermal therapy functions. The composite nanoparticles with the photoacoustic development and photothermal therapy functions are formed by coupling graphene quantum dots (GQDs) of surface-PEGylated composite porphyrin molecules and copper sulfidenanoparticles (CuS) modified with hyaluronic acid on the surface. According to the preparation method, GQDs-PEG-P is coupled to the surfaces of the HA-CuS nanoparticles, so that the composite nanoparticles with the photoacoustic development and photothermal therapy functions are obtained. The composite nanoparticles with the photoacoustic development and photothermal therapy functions has the characteristics of good biocompatibility, remarkable photothermal conversion efficiency, excellent photostability and the like, can realize multiple functions of biosensing and tumor diagnosis and treatment, and is beneficial to practical application; and besides, the preparation process is simple, green and pollution-free, and can be popularized and used.
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Description

technical field

[0001] The invention belongs to the technical field of nanoparticle preparation, and in particular relates to a composite nanoparticle with photoacoustic imaging and photothermal treatment functions. Background technique

[0002] At present: Cancer has become one of the most important diseases threatening human health. About 8.8 million people die from cancer every year in the world, and more than 14 million new cancer cases occur. At present, the main means of clinical cancer treatment include surgical resection and chemotherapy. However, for many diffuse and invasive malignant tumors, surgical resection cannot completely eliminate tumor cells, and the possibility of recurrence is high; and chemotherapy drugs often have many side effects, such as nephrotoxicity and neurotoxicity. Near-infrared photothermal therapy is a treatment method that converts light energy into heat energy to kill tumor cells under the irradiation of near-infrared light after material...

Claims

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