Transcranial magnetoacoustic coupling electrical stimulation device and method with controllable magnetic field

Abstract

The invention relates to a transcranial magnetoacoustic coupling electrical stimulation device and method with a controllable magnetic field. The device comprises an ultrasonic probe, a magnetic field generation assembly and a signal acquisition assembly; the magnetic field generation assembly comprises an operation table and a Helmholtz coil; the device is characterized in that the Helmholtz coil is placed on the operation table and is connected with a power supply; a to-be-stimulated object is placed on the operation table, the head of the to-be-stimulated object is located in the middle of the Helmholtz coil, the Helmholtz coil is electrified to generate a magnetic field, and the size and type of the magnetic field are adjusted by changing the size and type of current output by the power supply; and the ultrasonic probe acts on the head of the to-be-stimulated object, and a photoelectric signal acquisition assembly is used for acquiring a fluorescence signal and a local field potential signal after the to-be-stimulated object is stimulated. According to the device, the size and the type of a magnetic field are adjustable, a local field potential signal and a fluorescence signal after stimulation are collected, the coupling strength of the local field potential signal and the strength change of the fluorescence signal are fused to construct an adjusting index, and accurate regulation and control are achieved.

Description

technical field [0001] The invention belongs to the technical field of nerve regulation, and in particular relates to a transcranial magnetoacoustic coupling electric stimulation device and method with controllable magnetic field. Background technique [0002] Neuropsychiatric diseases have become an important factor affecting people's quality of life. At present, commonly used neuromodulation methods are divided into two categories: invasive and non-invasive. Invasive methods mainly include deep brain stimulation. Electrodes are implanted into the deep part of the brain, and neuromodulation is performed through micro-current stimulation to treat movement disorders and neurological diseases. This method has surgical risks and a low safety factor. Non-invasive methods mainly use physical energy such as sound, light, and electromagnetic energy for neuromodulation, and do not require invasive surgery. Currently, non-invasive neuromodulation includes transcranial magnetic stimul...

AI Technical Summary

Problems solved by technology

[0004] Most of the existing magnetoacoustic coupling electric stimulation devices use permanent magnets to generate static magnetic fields. The size of the magnetic field is fixed and the type of magnetic field is single. If the size of the magnetic field is changed, it is necessary to replace the permanent magnets of different types, which brings a lot of inconvenience to the research.

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