Marker for predicting hereditary angioedema attack and application thereof

An angioedema and hereditary technology, applied in the field of microbiology and bioinformatics, achieves the effects of short measurement cycle, high sensitivity and reduced incidence

Pending Publication Date: 2021-12-03
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Claims
  • Application Information

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Problems solved by technology

[0006] So far, there is no research report on the correlation

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  • Marker for predicting hereditary angioedema attack and application thereof
  • Marker for predicting hereditary angioedema attack and application thereof
  • Marker for predicting hereditary angioedema attack and application thereof

Examples

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Embodiment 1

[0055] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention. Unless otherwise specified, the examples are all in accordance with conventional experimental conditions, such as Sambrook et al. Molecular Cloning Experiment Manual (Sambrook J & Russell DW, Molecular Cloning: a Laboratory Manual, 2001), or in accordance with the conditions suggested by the manufacturer's instructions. The establishment and screening of embodiment 1 model algorithm

[0056] The present invention finds the most suitable model and specific species of bacteria as microbial markers through preliminary screening operations, optimizes the parameters of the model according to the data with class labels, improves the accuracy and sensitivity of the model, and predicts through the output risk value, and can Indicate the balance of intestinal microorganisms, guide the adjustment of individualized intestinal flora, and reduce the ...

Embodiment 2

[0070] The bacterium of embodiment 2 specific species is selected

[0071] 1. The XGBoost model obtains the Feature-importance score of the variable feature ( Figure 5 ), according to the high and low ranking of the score, gradually increase the number of bacterial variables to obtain the variables required for the optimal ROC-AUC. The results show that the ROC-AUC value is the largest when inputting the bacterial abundance of 15 specific species of characteristic variables.

[0072] 2. To test the model, split the data into a training set and a test set, input the bacterial abundance of 15 specific species in the sample, and input it into the Xgboost model. The parameters of the model are optimized according to GridsearchCV, trained with the training set, and tested with the test set.

[0073] 3. The storage model is used for the prediction of disease risk of subsequent measurement data.

[0074] The number and combination of input variables will produce different ROC-AUC. ...

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Abstract

The invention provides a marker for predicting hereditary angioedema attack and application thereof. The marker is the relative abundance of 15 bacteria in the intestinal tract in the intestinal flora. After the relative abundance data of the 15 bacteria is input into an XGBoost model, the obtained score is greater than or equal to 0.402, the hereditary angioedema attack risk is high, and the obtained score is less than 0.402, and no hereditary angioedema attack risk exists. The invention discovers that the intestinal flora is closely related to the HAE attack for the first time, and establishes a set of markers and risk early warning models for hereditary angioedema acute attack based on the intestinal flora, which can assist the clinical prediction of HAE acute attack in advance, and has important clinical significance for reducing the incidence of HAE acute edema and improving the disease treatment rate.

Description

technical field [0001] The present invention relates to microbiome and bioinformatics, in particular, to markers for predicting the onset of hereditary angioedema and applications thereof. Background technique [0002] Hereditary angioedema (hereditary angioedema, HAE) is a rare, life-threatening genetic disease with an incidence of about 1 / 10000-1 / 50000. Edema is characterized by non-pitting, self-limiting, localized, and unpredictable features. Commonly involved sites include the face, extremities, trunk, reproductive tract, upper respiratory tract, and gastrointestinal tract. The symptoms exhibited by HAE patients have obvious clinical heterogeneity, specifically in the age of onset, frequency, predilection site, and severity. It only manifests as mild acro edema, which does not affect normal daily life. In severe cases, if the gastrointestinal tract is involved, unbearable abdominal pain, nausea, vomiting, diarrhea, and peritoneal effusion may occur, and respiratory muc...

Claims

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Application Information

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IPC IPC(8): C12Q1/689G16H50/30G16B5/00G16B40/00C12R1/01C12R1/20
CPCC12Q1/689G16H50/30G16B5/00G16B40/00
Inventor 支玉香曹阳阚浩轩
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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