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Protection method for radiation-induced lung injury

A radiation-induced lung injury and body technology, applied in the field of radiation protection, can solve problems such as low-calcium tetany, gastrointestinal dysfunction, etc., and achieve the effects of good radiation-induced lung injury protection, reduction of pathological damage, and improvement of antioxidant capacity

Pending Publication Date: 2021-12-10
CHINA INST FOR RADIATION PROTECTION
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Amifostine is the first pan-cell protective agent approved by the US FDA. After continuous research by clinicians, it is currently widely used to protect normal cells from damage caused by radiotherapy rays and chemotherapy drugs. Fostin will cause adverse reactions such as gastrointestinal dysfunction, hypotension, hypocalcemia tetany, etc.

Method used

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  • Protection method for radiation-induced lung injury
  • Protection method for radiation-induced lung injury
  • Protection method for radiation-induced lung injury

Examples

Experimental program
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Embodiment 1

[0025] The specific implementation manners of the present invention will be further described below in conjunction with the embodiments and the accompanying drawings. Example 1: Protection against radiation-induced lung injury in rats

[0026] (1) Experimental animals and grouping

[0027] Fifteen SPF-grade male SD rats aged 6-8 weeks, weighing (205±15) g, were provided by Beijing Weitong Lihua Experimental Animal Company [SCXK (Beijing) 2016-0006]. The animals were kept in the animal laboratory of the GLP Center of the Chinese Institute of Radiation Protection [SYXK (Jin) 2013-0002]. According to the weight of the animals, they were randomly divided into control group, model group and treatment group, with 5 animals in each group. Rats were housed in separate cages, 5 in each cage, with free access to food and water.

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Abstract

The invention belongs to the technical field of radiation protection and relates to a protection method for radiation-induced lung injury. The protection method comprises the following steps: injecting amifostine into an organism before irradiation, and controlling a body temperature of the organism within a mild hypothermia range after irradiation. By means of the protection method for the radiation-induced lung injury, disclosed by the invention, the injury degree of lung tissue of the organism after irradiation can be safely and efficiently reduced; and when the amifostine injection before irradiation is combined with the application of controlling the body temperature within the mild hypothermia range after irradiation to prepare a medicament for preventing and / or treating the radiation-induced lung injury, the radiation-induced lung injury can be safely and efficiently prevented and / or treated.

Description

technical field [0001] The invention belongs to the technical field of radiation protection, and relates to a protection method for radiation-induced lung injury. Background technique [0002] In recent years, the incidence of lung cancer has continued to rise. Radiation therapy, as the main treatment for lung cancer, is more common after treatment and is likely to be accompanied by serious complications of radiation lung injury. In response to the increasing number of radiation-induced lung injuries, it is extremely important to seek efficient and low-toxic radiation protection methods. [0003] Amifostine is the first pan-cell protective agent approved by the US FDA. After continuous research by clinicians, it is currently widely used to protect normal cells from damage caused by radiotherapy rays and chemotherapy drugs. Fostin will cause adverse reactions such as gastrointestinal dysfunction, hypotension, hypocalcemia tetany, etc. [0004] Mild hypothermia therapy is a ...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61P11/00A61P39/00A61F7/00A61N5/10
CPCA61K31/661A61P11/00A61P39/00A61F7/00A61N5/103A61N2005/1092
Inventor 王远飞李曙芳许文黎黄立群孙鸽尹晶晶王新钢张伟袁慧郭剑平杨彪
Owner CHINA INST FOR RADIATION PROTECTION
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