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Application of ASB17 in preparation of medicine for treating TRAF6 related inflammatory diseases

A technology for inflammatory diseases and drugs, applied in the field of ASB17 in the preparation of TRAF6-related inflammatory disease drugs, can solve problems such as no research

Pending Publication Date: 2021-12-10
佛山病原微生物研究院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Through the above analysis, the problems and defects of the existing technology are: the regulation mode of ASB17, and how to down-regulate the expression level of ASB17 to inhibit the inflammatory response mediated by TRAF6 have not been resolved, and there is basically no research on the function of ASB17

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  • Application of ASB17 in preparation of medicine for treating TRAF6 related inflammatory diseases
  • Application of ASB17 in preparation of medicine for treating TRAF6 related inflammatory diseases
  • Application of ASB17 in preparation of medicine for treating TRAF6 related inflammatory diseases

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Embodiment Construction

[0088] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0089] In view of the problems existing in the prior art, the present invention provides a use of ASB17 in the preparation of TRAF6-related inflammatory disease medicines. The present invention will be described in detail below with reference to the accompanying drawings.

[0090] like Image 6 As shown, the method for verifying that ASB17 prepares a drug for treating TRAF6-related inflammatory diseases provided by the embodiments of the present invention includes the following steps:

[0091] S101, the isolation of primary mouse cells BMDCs and BMDMs;

[0092] S102, Western blotting, co-immunoprecipitation, and immunoflu...

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Abstract

The invention belongs to the technical field of biological medicine, and discloses application of ASB17 in preparation of a medicine for treating TRAF6 related inflammatory diseases, the Human ASB17 Sequence. Txt sequence of the ASB17 is shown as SEQ ID NO: 1, and the Mouse ASB17 Sequence. Txt sequence of the ASB17 is shown as SEQ ID NO: 2; the method for verifying ASB17 to prepare the medicine for treating the TRAF6 related inflammatory diseases comprises the following steps: separating mouse primary cells BMDCs and BMDMs; carrying out western blotting, co-immunoprecipitation and immunofluorescence; and protein stability detection and ubiquitination experiment. Through research and speculation, ASB17 and TRAF6 interact with each other, so that ubiquitination of TRAF6K48 can be inhibited, TRAF6 can be stabilized, and TRAF6-mediated inflammatory response can be promoted.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of ASB17 in the preparation of TRAF6-related inflammatory disease drugs. Background technique [0002] Currently, dendritic cells (DCs) are essential for fighting pathogens but may also contribute to immunopathology. They link innate and acquired immune responses and play an essential role in host defense against invading pathogens. Type I conventional DCs (cDC1s) and cDC2s develop from common DC precursors in a BATF3 / IRF-8 and IRF4-dependent manner, respectively, whereas plasmacytoid DCs (pDCs) may arise from common DCs and common lymphoid progenitors . Pathogen detection by dendritic cells is primarily mediated by pattern recognition receptors (PRRs), which are critical for dendritic cell activation and subsequent immune responses. Among the PRRs are TLRs, consisting of 10 members in humans and 12 members in mice. Interestingly, TLR11 and TLR12, whic...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61P29/00G01N33/68
CPCA61K45/06A61P29/00G01N33/68
Inventor 吴建国杨戈万品潭秋萍
Owner 佛山病原微生物研究院
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