Modified ubiquitin proteins having a specific binding activity for the extradomain b of fibronectin
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- SCIL PROTEINS
- Publication Date
- 2012-11-29
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
FIELD OF THE INVENTION
[0001] The present invention refers to novel proteins, in particular hetero-multimeric proteins, capable of binding the extradomain B of fibronectin (ED-B). Furthermore, the invention refers to fusion proteins comprising said binding protein fused to a pharmaceutically and / or diagnostically active component. The invention is further directed to a method for the generation of such binding protein or fusion protein and to pharmaceutical / diagnostic compositions containing the same. In addition, the invention refers to libraries which are based on a scaffold protein comprising linear polyubiquitin chains with at least two interacting binding determining regions (BDR).
[0002] In further embodiments, the invention is directed polynucleotides coding for said binding protein or fusion protein, vectors comprising said polynucleotide and host cells comprising said protein, fusion protein, vector and / or polynucleotide. In a preferred embodiment, said binding protein or fusio...