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Purity detection of separated sample portion as basis for a positive or negative decision concerning further separation

A sample and purity technology, applied in the preparation of test samples, separation methods, material separation, etc.

Pending Publication Date: 2021-12-17
AGILENT TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Purity detection of separated sample portion as basis for a positive or negative decision concerning further separation
  • Purity detection of separated sample portion as basis for a positive or negative decision concerning further separation
  • Purity detection of separated sample portion as basis for a positive or negative decision concerning further separation

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Embodiment Construction

[0063] Before describing the figures in more detail, some basic considerations of the invention, on the basis of which the exemplary embodiments have been developed, will be summarized.

[0064] According to an exemplary embodiment of the present invention, spectroscopic analysis or mass spectrometry may be performed on the eluate from the first separation stage or primary separation stage of the sample separation device to record the eluate spectrum based on chromatographic peaks. Based on the temporal resolution of such peaks of such a chromatogram, the purity of the portion of the fluid sample related to said peak can be determined. For example, one or more spectra around a peak can be recorded. The one or more spectra may be compared to one or more predetermined reference spectra, and / or potential changes in the spectra over time may be observed. Based on such an analysis, it can be determined whether the sample section corresponding to the peak comprises a pure substance...

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Abstract

The invention relates to purity detection of separated sample portion as basis for a positive or negative decision concerning further separation. A sample separation apparatus for separating a fluidic sample includes an initial dimension sample separation device configured for separating the fluidic sample, a subsequent dimension sample separation device configured for further separating separated fluidic sample received from the initial dimension sample separation device, a purity detector configured for detecting information indicative of a purity of a portion of the fluidic sample which has been separated by the initial dimension sample separation device, and a control unit configured for controlling, depending on the detected information, whether or not further separation of the portion of the fluidic sample which has been separated by the initial dimension sample separation device is carried out by the subsequent dimension sample separation device.

Description

technical field [0001] The present invention relates to a sample separation device and a method of separating a fluid sample. Background technique [0002] In liquid chromatography, a fluid sample and an eluent (liquid mobile phase) can be pumped through a conduit and a column where the sample components are separated. Columns may comprise materials capable of separating different components of fluid analytes. This packing material, which may comprise silica gel, so-called beads, can be filled into a column tube which can be connected to other elements (such as a control unit, containers including samples and / or buffers) via conduits. The composition of the mobile phase can be adjusted by composing the mobile phase with different fluid components with variable proportions. [0003] Two-dimensional separation of a fluid sample denotes a separation technique in which a first separation procedure is carried out in a first separation unit to separate a fluid sample into compon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/34G01N30/06G01N30/02G01N21/25G01N21/33G01N21/64G01N27/62
CPCG01N1/34G01N30/06G01N30/02G01N21/25G01N21/33G01N21/64G01N27/62G01N30/463G01N30/465G01N27/44773G01N30/8689B01D53/025B01D57/02G01N30/44G01N30/7206G01N30/7233G01N30/728G01N30/74G01N2030/445G01N30/72G01N30/8651G01N30/8631B01D15/1878G01N2030/025
Inventor 乌尔里希·埃伯哈丁格
Owner AGILENT TECH INC