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Analysis method and system based on ctDNA length

An analysis system and analysis model technology, applied in the field of biomedicine, can solve problems such as the increase in the proportion of cfDNA, and achieve the effects of assisting early diagnosis, improving screening efficiency and accuracy, simplicity, convenience and accuracy

Active Publication Date: 2022-04-08
臻和(北京)生物科技有限公司 +2
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Problems solved by technology

In addition, many recent studies have also shown that the proportion of short-length cfDNA increases in advanced cancer patients

Method used

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  • Analysis method and system based on ctDNA length
  • Analysis method and system based on ctDNA length
  • Analysis method and system based on ctDNA length

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Embodiment Construction

[0045] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the specific implementation manners of the present invention will be described below with reference to the accompanying drawings. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention, and those skilled in the art can obtain other accompanying drawings based on these drawings and obtain other implementations.

[0046] The first embodiment of the present invention, such as figure 1 As shown, an analysis method based on the length of ctDNA includes: S10 performing low-depth whole-genome sequencing on the plasma sample to be tested based on NGS platform; The ratio ratio of the number of short inserts and long inserts is calculated. The number of short inserts in the whole genome is calculated according to the preset short insert interval threshold, and the number of long inserts is counted ...

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Abstract

The present invention provides an analysis method and system based on the length of ctDNA, wherein the analysis method includes: performing low-depth whole-genome sequencing on the plasma sample to be tested based on the NGS platform; dividing the whole-genome interval by using a window of a pre-selected size , and calculate the ratio ratio of the number of short insertions and long insertions in each window, the number of short insertions is calculated according to the preset interval threshold of short insertions, and the number of long insertions is calculated according to the preset long insertion The fragment interval threshold is statistically obtained; the number ratio ratio obtained by the statistics uses the pre-trained ctDNA length analysis model to obtain the score of the plasma sample to be tested, and then the plasma sample to be tested is analyzed according to the score. This method can accurately analyze the cfDNA length of the plasma sample to be tested, and provide a partial basis for subsequent applications.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an analysis method and system based on ctDNA length. Background technique [0002] According to the "Journal of the American Medical Association", the top 10 cancers with the highest incidence in the world are: non-melanoma skin cancer, lung cancer, breast cancer, colorectal cancer, prostate cancer, gastric cancer, liver cancer, cervical cancer, non-cholesterol Chickkin's lymphoma and bladder cancer. The top 10 cancers in the global mortality rate are: lung cancer, colorectal cancer, gastric cancer, liver cancer, breast cancer, pancreatic cancer, esophageal cancer, prostate cancer, cervical cancer and non-Hodgkin's lymphoma. Most of the morbidity and mortality from human cancer worldwide is due to late diagnosis due to poor response to therapeutic interventions. Unfortunately, clinically proven biomarkers that can be used to diagnose and treat patients are not widely availa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B40/00G16B25/10G16B25/20G16B30/10C12Q1/6869
CPCG16B40/00G16B25/10G16B25/20G16B30/10C12Q1/6869C12Q2535/122C12Q2537/165
Inventor 杨顺莉于佳宁张亚晰刘异倩李宇龙陈维之何骥杜波
Owner 臻和(北京)生物科技有限公司
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