Bioglass hydrogel drug loading platform as well as preparation method and application thereof
A bioglass and hydrogel technology, applied in pharmaceutical formulation, pharmaceutical science, capsule delivery, etc., can solve the problems of lack of responsive drug release and anti-cancer characteristics, single function of hydrogel, inability to reduce systemic side effects, etc. To achieve the effect of improving responsive drug release performance and reducing systemic toxicity
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[0050] The embodiment of the present application provides a bioglass hydrogel drug-loading platform, and the specific preparation method includes:
[0051] Dissolve 2.80g of cetyltrimethylammonium bromide into 135mL of deionized water to form a solution, add 40mL of ethyl acetate, add 28mL of ammonia water, stir for 15min, add 14.4mL of tetraethyl orthosilicate, stir for 30min, then add 9.12 g of calcium nitrate tetrahydrate formed a milky white solution, stirred for 4 hours, washed with water and centrifuged to separate the precipitate, and calcined at 760° C. for 2.5 hours to obtain mesoporous bioglass nanoparticles.
[0052] Add 500 mg of the above-prepared mesoporous bioglass nanoparticles and 1.0 mL of silane coupling agent 3-aminopropyltriethoxysilane to 100 mL of acetone, and continuously stir at 65 °C for 6 hours, wash with acetone to remove excess silane coupling agent. The aminated bioglass was obtained after vacuum drying at 60 °C.
[0053] Dissolve 57.5 mg of 1-(...
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