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Bioglass hydrogel drug loading platform as well as preparation method and application thereof

A bioglass and hydrogel technology, applied in pharmaceutical formulation, pharmaceutical science, capsule delivery, etc., can solve the problems of lack of responsive drug release and anti-cancer characteristics, single function of hydrogel, inability to reduce systemic side effects, etc. To achieve the effect of improving responsive drug release performance and reducing systemic toxicity

Pending Publication Date: 2022-02-08
HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of this, this application provides a bioglass hydrogel drug-loading platform and its preparation method and application, which can solve the problem that the ex

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  • Bioglass hydrogel drug loading platform as well as preparation method and application thereof
  • Bioglass hydrogel drug loading platform as well as preparation method and application thereof
  • Bioglass hydrogel drug loading platform as well as preparation method and application thereof

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Embodiment 1

[0050] The embodiment of the present application provides a bioglass hydrogel drug-loading platform, and the specific preparation method includes:

[0051] Dissolve 2.80g of cetyltrimethylammonium bromide into 135mL of deionized water to form a solution, add 40mL of ethyl acetate, add 28mL of ammonia water, stir for 15min, add 14.4mL of tetraethyl orthosilicate, stir for 30min, then add 9.12 g of calcium nitrate tetrahydrate formed a milky white solution, stirred for 4 hours, washed with water and centrifuged to separate the precipitate, and calcined at 760° C. for 2.5 hours to obtain mesoporous bioglass nanoparticles.

[0052] Add 500 mg of the above-prepared mesoporous bioglass nanoparticles and 1.0 mL of silane coupling agent 3-aminopropyltriethoxysilane to 100 mL of acetone, and continuously stir at 65 °C for 6 hours, wash with acetone to remove excess silane coupling agent. The aminated bioglass was obtained after vacuum drying at 60 °C.

[0053] Dissolve 57.5 mg of 1-(...

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Abstract

The invention belongs to the technical field of biological materials, and particularly relates to a bioglass hydrogel drug loading platform as well as a preparation method and application thereof. The preparation method of the drug loading platform provided by the invention comprises the following steps: performing amination activation on mesoporous bioglass nanoparticles, a silane coupling agent and an organic solvent to obtain aminated bioglass; subjecting the aminated bioglass, activated dithio glycolic acid and a target drug to mixing and reacting so as to obtain drug-loaded bioglass nanoparticles; and mixing the drug-loaded bioglass nanoparticles, an oxidized chondroitin sulfate solution and a gelatin solution and conducting crosslinking to obtain bioglass hydrogel. The hydrogel provided by the invention has pH response performance, is improved in responsive drug release performance, also shows bone guidance and bone induction activity, and is beneficial to application of clinical bone defect repair; and the hydrogel can respond to a tumor microenvironment to quickly release chemotherapy drugs, and overcomes the defects that existing hydrogel is single in function, does not have response type drug release anti-cancer characteristics and cannot reduce toxic and side effects of the whole body.

Description

technical field [0001] The application belongs to the technical field of biomaterials, and in particular relates to a bioglass hydrogel drug-loading platform and its preparation method and application. Background technique [0002] Cancer is a major disease that threatens human health and brings a heavy burden to the social economy. The incidence and mortality of cancer in my country rank first in the world. At present, the commonly used clinical method is surgical resection combined with postoperative radiotherapy and chemotherapy. Tumor surgery often leads to bone defects, seriously affecting the quality of life of patients, and requires autologous tissue or bone repair materials for defect repair and reconstruction. However, surgery is difficult to completely remove tumor lesions. Taking osteosarcoma as an example, the postoperative recurrence and metastasis rate is as high as 30%, and the 3-year survival rate is less than 50%. At present, none of the commonly used auto...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/12A61L31/16
CPCA61L31/145A61L31/16A61L31/127A61L31/146A61L2430/02A61L2300/416A61L2300/624A61L2300/412C08L89/00C08L5/08
Inventor 王焱蔡敏宁成云周蕾李晓君黄静燕
Owner HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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