Application of ferroptosis-related genes in prognostic assessment of diffuse large B-cell lymphoma

A prognostic assessment, lymphoma technology, applied in the field of disease prognosis and molecular biology, to achieve a good predictive effect
CN114045339BActive Publication Date: 2022-06-28SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
Publication Date
2022-06-28

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Abstract

The invention provides the application of ferroptosis-related genes in the prognosis evaluation of diffuse large B-cell lymphoma, and belongs to the technical field of disease prognosis and molecular biology. The present invention constructs a diffuse large B-cell lymphoma prognostic model based on ferroptosis-related genes, thereby predicting and evaluating the prognosis of diffuse large B-cell lymphoma. Experiments have proved that the prognostic model is significantly related to the OS of DLBCL patients, and DLBCL with high risk value The OS of patients is significantly shorter than that of patients with low risk values, and the possibility of death is also greater, so it has a good predictive effect, which can be used to predict the prognosis of diffuse large B-cell lymphoma and to assist clinical decision-making, and has good practical application value.
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Description

technical field

[0001] The invention belongs to the technical field of disease prognosis and molecular biology, and particularly relates to the application of ferroptosis-related genes in the prognosis evaluation of diffuse large B-cell lymphoma. Background technique

[0002] The information disclosed in this Background section is only for enhancement of understanding of the general background of the invention and should not necessarily be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.

[0003] Diffuse large B-cell lymphoma (DLBCL) is a malignant and aggressive tumor derived from B-lineage lymphocytes, accounting for 30–40% of non-Hodgkin lymphomas. DLBCL is a highly heterogeneous lymphoid tumor with variations in gene expression profiles and altered genetic information. Currently, R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) is the most...

Claims

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