Pyridazine compound and application thereof
A compound, pyridazine technology, applied in the field of pesticide compounds, can solve the problem that it is difficult to take into account the effects of weed control and crop safety, and achieve excellent weed control effect and excellent safety effect
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[0080] Preferably, the preparation method of the compound of the structure shown in the formula (II) comprises: in the presence of the second solvent and the second alkali, the compound shown in the formula (IV) and the phosphorus oxychloride shown in the formula (V) react,
[0081]
[0082] The substituents in the compound represented by formula (IV) are correspondingly the same as those described above in the present invention.
[0083] Preferably, the preparation method of the pyridazinone with the structure shown in formula (IV) comprises: in the presence of a third solvent and a third base, combining the raw material shown in formula (IV) with the compound shown in formula (V) Hydrazine monohydrate reacts,
[0084] N 2 h 4 .H 2 O formula (VII).
[0085] The substituents in the compound represented by formula (IV) are correspondingly the same as those described above in the present invention.
[0086] Preferably, the preparation method of the raw material of the...
preparation example 1
[0111] Preparation Example 1: Preparation of Compound 2
[0112]
[0113] Preparation of material ii
[0114] In a 250mL two-necked bottle, add material 98mmol of material i and 0.5mL of 98wt% H 2 SO 4 , slowly add 100mL of ethanol under stirring at room temperature, and react at 80°C. After the reaction is complete as detected by TLC, the solvent is removed under reduced pressure.
[0115] Add 200 mL of saturated Na 2 CO 3 The aqueous solution was extracted with 200 mL of dichloromethane, and the organic phase was washed with saturated NaCl aqueous solution, then dried by adding anhydrous sodium sulfate, filtered, and desolvated under reduced pressure to obtain a slightly yellow transparent liquid, and the crude product was directly used for the next reaction.
[0116] Preparation of material iii
[0117] In a 250mL two-necked bottle, add the crude product material ii obtained in the previous step, add 100mL of CCl 4 Dissolve, add 9.8mmol of azobisisobutyronitrile th...
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