Core fucose identification method, system, equipment, medium and terminal

Abstract

The invention belongs to the technical field of core fucose identification, and discloses a core fucose identification method, system and equipment, a medium and a terminal.The core fucose identification method comprises the steps that characteristic ions are introduced; preprocessing the data; model training; calculating a threshold value; and identifying the core fucose. According to the method, core fucose which does not exist in FUT8 mouse tissues is removed, characterization of non-core fucose data is learned through a self-encoder, and core fucose identification is regarded as an abnormal detection problem, so that the problems of non-core fucose with fucose migration in training data and label errors of the core fucose data are avoided. The method is simple to operate, and training data only contains non-core fucose data; 10 characteristic ions are introduced technically, the abundance of the characteristic ions is input into a self-encoder, and a conclusion whether the mass spectrum to be identified is the core fucose mass spectrum is obtained. The method can also distinguish core fucose from non-core fucose with fucose migration, and the identification speed is high.

Description

technical field [0001] The invention belongs to the technical field of core fucose identification, and in particular relates to a core fucose identification method, system, equipment, medium and terminal. Background technique [0002] Core fucosylation alters the secondary and tertiary conformation of glycoproteins, thereby playing important roles in tumor progression, immune regulation, and stem cell differentiation. Core fucosylation. It has been reported that compared with normal tissues, the level of core fucose in tumor tissue is increased, immunoglobulins bind to receptors on the surface of natural killer cells and macrophages to induce immune responses, and N-glycans in antibodies occur in core rocks. After alcosylation, the affinity of the antibody to the receptor is reduced by 98% to 99%. Moreover, many core fucose-modified glycoproteins can serve as important biomarkers of tumors, for example, alpha-fetoprotein is an important biomarker of hepatocellular carcinom...

AI Technical Summary

Problems solved by technology

[0020] Aiming at the problems existing in the prior art, the present invention provides a core fucose identification method, system, equipment, medium and terminal, and particularly relates to an autoencoder-based core fucose identification method, system, equipment, and medium And the terminal, aiming to solve the problem that the existing core fucose identification algorithm based on mass spectrometry technology cannot distinguish the core fucose mass spectrum from the non-core fucose mass spectrum with fucose migration

Images