Biomarkers for irritable bowel syndrome

A technology for irritable bowel syndrome and compounds, applied in biological testing, biomaterial analysis, instruments, etc.

Pending Publication Date: 2022-03-11
UNIV OF LIVERPOOL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is currently difficult to predict which IBS patients will benefit from this dietary intervention

Method used

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  • Biomarkers for irritable bowel syndrome
  • Biomarkers for irritable bowel syndrome
  • Biomarkers for irritable bowel syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] feces volatile organic compounds

[0041] All participants were analyzed at baseline, week 1 and All stool samples collected at week 4 were analyzed for volatile organic compounds (VOC).

[0042] Volatile organic compounds (VOCs) are intermediates / terminals of metabolic pathways and reflect colonic metabolism [1]. Human feces contain significant amounts of VOCs, and one study has demonstrated that VOC profiles and individual VOCs differ between responders and non-responders to a low-FODMAP diet [2].

[0043] 250-300 μg of each sample was weighed into 2 ml glass vials (Crawford Scientific, Lanarkshire, UK) with magnetic septum caps and subjected to GC-MS. The SPME fiber used was DVB-CAR-PDMS, otherwise the protocol was the same as published by Reade et al. (2014) [1].

[0044] Volatile Organic Compound Extraction Protocol

[0045] The GC column used was a Zebron ZB-624 (Phenomenex, Macclesfield, UK) with an internal diameter of 0.25 mm, a length of 60 m, and a fi...

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Abstract

The present invention relates to a method of determining the likelihood that an individual has irritable bowel syndrome and whether an individual will respond to a dietary intervention. The invention also provides a method of determining the likelihood that an individual having irritable bowel syndrome responds to a dietary intervention. Also provided are uses of the compounds as defined herein as biomarkers.

Description

technical field [0001] The present invention relates to a method of determining the likelihood of an individual suffering from irritable bowel syndrome and whether the individual will respond to dietary intervention. The invention also relates to a method of determining the likelihood of an individual suffering from irritable bowel syndrome to respond to a dietary intervention. The present invention also relates to the use of cyclohexane carboxylic acid compounds as biomarkers to determine the likelihood that an individual suffering from irritable bowel syndrome will respond to a dietary intervention. Background technique [0002] Irritable bowel syndrome (IBS) is a common disorder that affects the digestive system. It is characterized by recurring symptoms such as stomach cramps, abdominal pain, bloating, diarrhea and / or constipation. These symptoms tend to come and go over time, but they can last for hours, days, weeks, or even months at a time. For many patients, this ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/64
CPCG01N33/64G01N2800/065
Inventor 凯文·惠兰布里奇特·威尔逊梅根·罗西克里斯·普罗伯特蕾切尔·斯莱特
Owner UNIV OF LIVERPOOL
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