Stabilization of resorcinol compounds in cosmetic compositions

A technology of cosmetic composition and resorcinol, which is applied in the direction of cosmetics, cosmetic preparations, dressing preparations, etc., can solve the problems of instability and difficulty in preparation, and achieve the effect of improving storage/oxidation stability

Pending Publication Date: 2022-03-18
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some of these compounds can be difficult to formulate because they are unstable in cosmetically acceptable vehicles

Method used

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  • Stabilization of resorcinol compounds in cosmetic compositions
  • Stabilization of resorcinol compounds in cosmetic compositions
  • Stabilization of resorcinol compounds in cosmetic compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] Evaluation of signs of degradation and stabilization of 4-alkylresorcinols

[0162] color measurement

[0163] By dissolving 4-hexylresorcinol (200 mg) or 4-ethylresorcinol (200 mg) in deionized water: butanediol (4:1; 20 ml) to produce a clear, colorless homogeneous solution, to prepare samples for color evaluation. A portion (5 ml) of each solution was added to 20 ml scintillation vials containing nicotinamide (B3) (50 mg), AceMet (acetylmethionine) (50 mg) or B3 (50 mg) + AceMet (50 mg), and Monitor at room temperature (-20-22°C). After 2 weeks, the color of each solution was assessed visually and L*a*b* measurements were determined experimentally using a Labscan XE instrument (Hunter Associates Labs Inc., Reston, VA) and processed with Universal software (version 4.10). The L* parameter measures darkness and lightness and ranges from black (L*=0) to white (L*=100). The a* parameter measures color content and intensity from green (a*0). The b* parameter also...

Embodiment 2

[0174] Example 2. ER and AceMet

[0175] Topical cosmetic compositions within the scope of the present invention are prepared.

[0176] The base formulations shown in the table below were prepared by heating the Phase A ingredients to 70 to 85°C with agitation. Heat Phase B ingredients to 70 to 85°C in a separate vessel with stirring. Then, add Phase A to Phase B while maintaining both phases at 70 to 85°C. The mixture was stirred at 70 to 85°C for at least 15 minutes, then cooled. Add phase C ingredients at 50°C, followed by phase D ingredients at 40°C.

[0177] Table 2. Base formulations

[0178]

[0179]

Embodiment 3

[0181] Additional cosmetic compositions falling within the scope of the present invention were prepared as shown in the table below.

[0182] table 3

[0183]

[0184]

[0185] The composition was prepared as follows:

[0186] 1. Heat Phase A to 80°C while mixing.

[0187] 2. Heat Phase B to 75°C in a separate container while mixing.

[0188] 3. Add B to A and mix for 15 minutes with heat maintained at 70-80°C; then turn off heat and continue mixing for another 15 minutes.

[0189] 4. Add Phase C and mix for 10 minutes at 50°C.

[0190] 5. Add Phase D and mix for 10 minutes at 40°C.

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Abstract

Topical cosmetic compositions containing 4-substituted resorcinol derivatives in combination with N-acetylmethionine exhibit improved storage stability and oxidative stability. A method of stabilizing 4-ethylresorcinol or 4-hexylresorcinol in a composition comprising a cosmetically acceptable vehicle by adding acetylmethionine to the composition in an amount sufficient to stabilize the 4-ethylresorcinol or 4-hexylresorcinol. The invention relates to the use of N-acetylmethionine and stabilized 4-substituted resorcinol derivatives in the manufacture of topical cosmetic compositions.

Description

technical field [0001] The present application provides topical cosmetic compositions comprising 4-substituted resorcinol derivatives stabilized with acetylmethionine. Background technique [0002] Beauty in the eye of the beholder is influenced by numerous biological and genetic factors. The basis for a natural-looking appearance that is beautiful lies in the skin, including the hair. Ideal skin should be smooth and even, with no visible surface imperfections other than a luminous appearance with even color distribution. Skin and hair problems in aging individuals can be caused by a variety of extrinsic or intrinsic factors, such as harmful UV radiation from the sun, environmental exposure, stress, fatigue, disease, or combinations thereof. [0003] Resorcinol (1,3-benzenediol) derivatives have been used to provide cosmetic benefits to the skin and hair. 4-Substituted resorcinol derivatives and preparations thereof have been used in skin lightening and other cosmetic app...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/44A61Q19/02
CPCA61Q19/02A61K8/447A61K8/347A61K2800/52
Inventor J·G·罗萨T·莫亚德尔
Owner UNILEVER IP HLDG BV
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