Application of sciaenops ocellatus zymolyte in improving depression-like behavior induced by chronic stress

Abstract

The invention belongs to the technical field of functional marine product application, and discloses application of sciaenops ocellatus zymolyte in improving depression-like behaviors induced by chronic stress. A chronic stress depression model mouse is constructed, the sciaenops ocellatus zymolyte is subjected to intragastric administration, the effect of the sciaenops ocellatus zymolyte on improving system inflammation caused by chronic stress is investigated, and the result shows that after sciaenops ocellatus peptide intervention, the despair state time of the mouse is remarkably shortened, and the exploration desire of the mouse on an open space and a high-altitude environment is remarkably increased; the behavioral performance is recovered to a normal level, namely the depression-like behavior of the mouse is obviously improved. The intervention effect is better than that of a fish oil group; the preliminary research on the mechanism finds that the sciaenops ocellatus zymolyte has good improvement effects on the significant decrease of the chronic stress-induced hippocampal monoamine neurotransmitter level, the body system inflammation and the significant increase of the lipopolysaccharide level in serum; the research result provides a theoretical basis for developing the sciaenops ocellatus zymolyte into a new generation of green and safe anti-depression food.

Description

technical field [0001] The invention belongs to the technical field of functional seafood applications, and more specifically relates to the application of red fish hydrolyzate in improving depression-like behaviors induced by chronic stress. Background technique [0002] Depression is a depressive disorder characterized by significant and persistent low mood. Clinically, low mood, stupor, and lack of desire for survival can be seen. Serum 5-hydroxytryptamine (5-hydroxytryptamine, 5-HT) content decreased significantly during the onset of the disease, accompanied by brain inflammation. According to the 2017 survey report of WHO, in the past 10 years, the number of patients with depression worldwide has increased by more than 18%, and as of 2015, it has exceeded 300 million. It is speculated that by 2030, depression will become one of the top contributors to the human disease burden. [0003] At present, the treatment of depression is mainly based on monoamine neurotransmitt...

AI Technical Summary

Problems solved by technology

The red snapper itself is delicious and popular among consumers. It is also rich in protein and contains a variety of amino acids in its muscles. However, there is no research report on the application of red snapper peptides in the treatment of depression.

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