Preparation and synchronous modification method of novel multifunctional embolism

A modification method and multi-functional technology, which can be used in medical science, surgery, surgical adhesives, etc., can solve the problems of inability to be visualized under X-ray, lack of adhesion, etc., and achieve good dispersion, permanent unity, and shape. Complete smooth effect
CN114288461AActive Publication Date: 2022-04-08SHANGHAI FIRST PEOPLES HOSPITAL +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI FIRST PEOPLES HOSPITAL
Publication Date
2022-04-08

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Abstract

The invention discloses a preparation and synchronous modification method of a novel multifunctional embolism, and particularly relates to research and development of embolism microspheres which are stable in structure, proper in size and capable of coating an imaging object with polydopamine, and visualization is realized on the basis of enhancing adhesion and treatment effects. In-vitro experiments prove the biocompatibility and the X-ray imaging capability of the material. The microspheres can also load chemotherapeutic drugs, and animal experiments prove that the microspheres have good embolism effects. The design embodies an excellent novel method for synthesizing the multifunctional embolism.
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Description

technical field

[0001] The invention belongs to the field of biological material preparation, and in particular relates to a preparation and synchronous modification method of a novel multifunctional embolism. Background technique

[0002] Interventional surgery has played a pivotal role in clinical practice. Polyvinyl alcohol (PVA) particles are commonly used solid embolisms in interventional procedures. Attachment and lack of imaging under X-ray.

[0003] In view of the lack of image-visualized adhesive solid embolic agents in current medical practice, the present invention uses PVA with good biocompatibility as a raw material, combines highly adhesive polydopamine (PDA), and simultaneously adds iodine (I) and other high-electron Density material, so as to realize the multifunctional unity of visibility, adhesion, loading and permanence of the new embolic material, and it has been verified experimentally. Contents of the invention

[0004] In order to solve the above-m...

Claims

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