Compound nano eye drops and preparation method thereof
An eye drop, nanotechnology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of insufficient retention time, avoid systemic adverse reactions, The effect of reducing water production and lowering intraocular pressure
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[0029] The present invention provides the preparation method of the compound nanometer eye drop described in above-mentioned technical scheme, comprises the following steps:
[0030] Brinzolamide, adhesive, stabilizer, brimonidine tartrate, osmotic pressure regulator and water are mixed, homogenized and then ground to obtain compound nano eye drops.
[0031] The present invention has no special limitation on the mixing method, and the mixing method well-known to those skilled in the art can be adopted, such as stirring and mixing; the present invention has no special limitation on the speed and time of the stirring and mixing, and the raw materials can be mixed evenly Can.
[0032] In the present invention, the pressure of the homogeneous treatment is preferably 10 to 20 MPa, more preferably 12 to 18 MPa, further preferably 14 to 15 MPa, and the rotational speed of the homogeneous treatment is preferably 5000 to 10000 r / min, more preferably 6000-9000r / min, more preferably 700...
Embodiment 1
[0038] Mix 1g of brinzolamide, 2g of chitosan, 10g of polysorbate 80 and 50g of water for injection to obtain a mixed solution of brinzolamide;
[0039] 1g of brimonidine tartrate is added to 20g of water for injection, fully stirred to dissolve, and brimonidine tartrate solution is obtained;
[0040] Under stirring conditions, the brimonidine tartrate solution was added to the brinzolamide mixed solution, 0.5g sodium chloride was added, and a high-pressure homogenizer was used for 30min under the conditions of 20MPa and 10000r / min, Obtain homogeneous liquid;
[0041] Use a high-energy grinder, use 0.2mm zirconia grinding beads as the grinding medium, grind the homogeneous solution at 2000r / min for 30min, add a 10wt% sodium hydroxide aqueous solution to adjust the pH to 6.8, add water for injection The volume was increased to 100mL to obtain a compound nano eye drop with a particle size of 132nm, wherein the mass ratio of the homogeneous solution to zirconia was 1:5, and the ...
Embodiment 2
[0043] 1g of brinzolamide, 0.5g of chitosan, 20g of polysorbate 60 and 50g of water for injection were mixed to obtain a brinzolamide mixed solution;
[0044] 1g of brimonidine tartrate is added to 20g of water for injection, fully stirred to dissolve, and brimonidine tartrate solution is obtained;
[0045] Under stirring conditions, the brimonidine tartrate solution was added to the brinzolamide mixed solution, 0.5g sodium chloride was added, and a high-pressure homogenizer was used for 20min under the conditions of 15MPa and 8000r / min, A homogeneous solution was obtained.
[0046] Use a high-energy grinder, use 0.2mm zirconia grinding beads as the grinding medium, grind the homogeneous solution at 2000r / min for 30min, add a 10wt% sodium hydroxide aqueous solution to adjust the pH to 6.8, add water for injection The volume was increased to 100mL to obtain a compound nano eye drop with a particle size of 240nm, wherein the mass ratio of the homogeneous solution to zirconia wa...
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