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Methods and kits for predicting and screening for severe risk of cerebral microhemorrhage

A severe and risky technology, applied in the field of prediction and screening of severe risk of cerebral microbleeds and kits, can solve the problems of stroke incidence and recurrence rate

Pending Publication Date: 2022-04-12
H U GRP RES INST GK +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, it is also known that in patients with multiple cerebral microbleeds, the incidence and recurrence rate of stroke due to hemorrhage (cerebral hemorrhage) are high

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  • Methods and kits for predicting and screening for severe risk of cerebral microhemorrhage
  • Methods and kits for predicting and screening for severe risk of cerebral microhemorrhage
  • Methods and kits for predicting and screening for severe risk of cerebral microhemorrhage

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Embodiment

[0092] Hereinafter, the present invention will be more specifically described based on examples, but the present invention is not limited to the following examples.

[0093] 1. Acquisition of genome sequence information and gene annotation

[0094] As samples, dental plaque collected with a swab was used from the tooth surfaces of patients (14 persons) admitted for stroke at the National Center for Circulatory Diseases Hospital in Japan. These patients were patients whose number of deep cerebral microbleeds was confirmed by head MRI.

[0095]First, each sample was spread on a light Streptococcus salivarius (MS) agar medium supplemented with bacitracin (Bacitracin) and sucrose (Sucrose), and cultured anaerobically at 37° C. for 48 hours. Rock-like colonies considered to be S. mutans morphologically were selected and further cultured anaerobically at 37° C. for 48 hours in BHI (brain heart infusion) medium. Next, centrifugation was performed at 7000 rpm for 10 minutes using a ...

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Abstract

The present invention addresses the problem of providing: a method capable of predicting the risk of severe cerebral microhemorrhage in a subject; and a method capable of screening a subject having a high risk of severe cerebral microhemorrhage. [Solution] A method for predicting the risk of severity of cerebral microhemorrhage in a subject, said method comprising a step for predicting the risk of severity of cerebral microhemorrhage in a subject using, as an index, the amino acid sequence length of an overlapping region in a CNM protein of Streptococcus mutans contained in a sample derived from the subject.

Description

technical field [0001] The present invention relates to a method for predicting the risk of developing cerebral microbleeds in a subject, a method for screening subjects with a high risk of developing cerebral microbleeds, and a kit for these methods. Background technique [0002] Cerebral microbleeds (Cerebral microbleeds: CMBs, MBs) show symptoms of a small amount of red blood cells flowing out of the ruptured capillaries. Compared with healthy people (5%), about 60% of patients with cerebral hemorrhage, cerebral It is found in about 35% of patients with infarction, about 30% of patients with Alzheimer's disease, and about 15% of patients with mild cognitive impairment. In addition, it is also known that the incidence and recurrence rate of stroke due to hemorrhage (cerebral hemorrhage) are high in patients with multiple cerebral microbleeds. Therefore, it is generally considered that the number and frequency of cerebral microbleeds are one of the essential elements for p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68C12Q1/6883
Inventor 汤原悟志西胁森卫猪原匡史齐藤聪服部赖都
Owner H U GRP RES INST GK