Traditional Chinese medicine composition for preventing and treating tumors and hand and foot numbness and pain after related treatment

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating tumors and hand and foot numbness and pain after related treatment. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 3 to 15 parts of radix angelicae pubescentis, 5 to 15 parts of herba taxilli, 2 to 15 parts of radix gentianae macrophyllae, 5 to 18 parts of radix angelicae sinensis, 3 to 20 parts of radix paeoniae rubra, 1 to 3 parts of herba asari, 1 to 10 parts of cortex cinnamomi, 1 to 3 parts of leech, 1 to 6 parts of scorpio and 4 to 15 parts of stiff silkworm. Clinical application shows that the traditional Chinese medicine composition can prevent and treat tumors and hand and foot numbness and pain after related treatment, relieve symptoms, relieve adverse reactions of operations, chemoradiotherapy, targeting and immunotherapy, improve clinical symptoms, improve the clinical benefit rate and life quality of cancer patients, prolong the lifetime and promote rehabilitation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition for preventing and treating tumors and related numbness and pain of hands and feet after treatment, and also relates to a preparation method of the composition. Background technique [0002] Malignant tumors are a global problem that seriously threatens human life and health. According to statistics, there will be about 19.3 million new cancer cases worldwide in 2020, and about 10 million deaths. It is estimated that by 2040, the number of new cancer cases worldwide will increase by 47% %. Cancer is the No. 1 or No. 2 cause of death among people under the age of 70 in 112 countries around the world. With the increasing attention of people and the continuous development of medical technology, the prognosis of cancer is getting better and better. The quality of life of cancer patients has gradually received more attention. ...

AI Technical Summary

Problems solved by technology

[0009] (2) Drug therapy: mainly includes the following drugs: (1) Antidepressants: represented by duloxetine and venlaxine. Both duloxetine and venlaxine are selective 5-hydroxytryptamine (5-HT) and norepinephrine (NE) reuptake inhibitors. A number of studies have shown that duloxetine can significantly improve the numbness and tingling of hands and feet in patients. The National Comprehensive Cancer Network (NCCN) guidelines recommend duloxetine Xetine is used for moderate peripheral neuropathy caused by immunotherapy. American Society of Clinical Oncology (ASCO) guidelines recommend duloxetine for the treatment of pain caused by chemotherapy-induced peripheral neuropathy. Therapeutic effects have also been demonstrated in several studies and are often used prophylactically due to its stronger inhibitory effects on serotonin at low doses and norepinephrine at higher doses. A A double-blind randomized controlled trial showed that duloxetine is more effective than venlafaxine. It is believed that venlafaxine is only beneficial to oxaliplatin-specific neurotoxicity and some acute neurotoxicity. Therefore, venlafaxine remains to be seen. Further research. (2) Antiepileptic drugs: represented by gabapentin and pregabalin. Gabapentin is a derivative of γ-aminobutyric acid (GABA), which is similar in structure to GABA and can change GABA metabolism, but the specific pharmacological effects have not yet been elucidated , which may be related to antagonizing N-methyl-D-aspartate receptors and inhibiting calcium channels in postsynaptic membranes. Pregabalin is also a GABA analogue, and its structure and effect are similar to gabapentin, but its specific pharmacological effects It is also not clear that the activity is 3-10 times that of gabapentin. Studies have shown that the two can improve the numbness and pain of hands and feet caused by tumors and related treatments, but some studies have also shown that the two have a general effect on peripheral neuropathy caused by chemotherapy. NCCN guidelines recommend gabapentin , Pregabalin for pain caused by moderate peripheral neuropathy caused by immunotherapy. (3) Neuroprotective agents: such as N-acetylcysteine ​​and glutathione, etc. N-acetylcysteine ​​activates glutathione Glutathione peroxidase, which leads to increased concentrations of glutathione in whole blood. Glutathione prevents the accumulation of platinum adducts in dorsal root ganglia through its high affinity for heavy metals, and glutathione can also inhibit Activation of the p53 signaling pathway protects nerves. Studies have shown that eight cycles of glutathione treatment before chemotherapy can significantly reduce the incidence of moderate to severe hand and foot numbness and pain. Therefore, glutathione and its precursor N-acetyl Cysteine ​​seems to be an option for prevention, and its therapeutic role remains to be studied. (4) Ion channel modulators: such as lidocaine, menthol. Lidocaine is an antiarrhythmic drug that has It has obvious excitatory and inhibitory biphasic effects and can block sodium channels. Studies have shown that intravenous injection of lidocaine can exhibit sustained analgesic effects, and topical use of lidocaine also has strong analgesic effects, but it is not convincing evidence. Menthol is a transient Transient receptor potential M8 channel activator, transient receptor potential M8 exhibits multiple roles in cold allodynia and cold-mediated analgesia. Studies have shown that topical application of 1% menthol cream can significantly reduce the Numbness and pain in hands and feet caused by tumor drugs, but some patients feel that the pain is aggravated after using it, so it is still necessary to choose carefully. (5) Other treatments: such as antioxidant mangafodipir, amifostine, vitamin E, etc., urea ointment for external use , uracil ointment, etc., all studies have shown that it can improve the symptoms of numbness and pain in the hands and feet, but more clinical studies are still needed to confirm.

[0010] Although there are many ways to treat tumors and related treatments for numbness and pain in hands and feet, some patients still have difficulty in relieving their symptoms clinically. The reasons are as follows: (1) Non-drug therapies usually take effect slowly and require long-term persistence and cooperation of patients. And there are few relevant clinical studies, and its curative effect needs to be further studied. ASCO guidelines do not recommend the use of this method for prevention; (2) The drugs commonly used in clinical practice and with good curative effects are duloxetine, gabapentin, and pregabalin. However, Duloxetine can cause various adverse reactions such as blood pressure increase, heart rate decrease, insomnia, headache, tremor, nausea, diarrhea, constipation, etc. Gabapentin has less adverse reactions than pregabalin, common drowsiness, dizziness, fatigue, eyeball Tremor, headache, nausea and vomiting, etc.; (3) Other drugs such as neuroprotective agents, ion channel modulators, antioxidants, etc., although clinical studies have confirmed that they can improve the symptoms of numbness and pain in hands and feet, but there are also studies that have obtained opposite results. The specific curative effect remains to be verified. The symptoms of numbness and pain in hands and feet after tumor and related treatment will not only affect the patient's body function, daily life, and mental health, but also reduce the patient's quality of life. It will also affect the normal treatment of cancer and affect the prognosis of the patient. , is a major problem to be solved, and currently there is no effective method that has a quick effect, has few side effects, has a wide range of applications, and can both prevent and treat.

Images