Application of diosmetin in preparation of medicine for treating prostatic cancer

A technology of prostate cancer and diosmin, applied in the direction of drug combination, pharmaceutical formula, antineoplastic drugs, etc., can solve problems such as limited activity, damage to patient's quality of life, pain, etc., and achieve the effect of inhibiting dryness

Pending Publication Date: 2022-04-29
遵义医科大学第二附属医院
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  • Abstract
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Problems solved by technology

Bone metastases in PCa lead to severe pain, l...

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  • Application of diosmetin in preparation of medicine for treating prostatic cancer
  • Application of diosmetin in preparation of medicine for treating prostatic cancer
  • Application of diosmetin in preparation of medicine for treating prostatic cancer

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Embodiment Construction

[0015] The present invention will be specifically introduced below in conjunction with the accompanying drawings and specific embodiments.

[0016] Dioxynignin is a flavonoid biological compound extracted from a variety of natural medicines, which has anti-inflammatory, anti-oxidation, anti-tumor and other active functions. At present, many studies have shown that diosmin can inhibit the proliferation of lung cancer, liver cancer and colorectal cancer in vitro and in vivo, but there are few studies on bone metastasis of PCa. This application takes prostate cancer cell PC-3 as the research object, and confirms the inhibitory effect of diosmin on prostate cancer cell PC-3.

[0017] 1. Materials

[0018] 1.1 Human prostate cancer PC-3 cell line was purchased from the Cell Bank of Shanghai Chinese Academy of Sciences.

[0019] 1.2 Dioxynignin (purity ≥ 98%) and DMSO were purchased from Sigma, USA.

[0020] 1.3 RPMI-1640 medium, fetal bovine serum, cytokines B27, EGF, and bFGF w...

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Abstract

The invention discloses an application of diosmetin in preparation of a medicine for treating prostatic cancer. The invention relates to an application of diosmetin in preparation of a medicine for treating prostatic cancer, and discloses that diosmetin can inhibit proliferation of prostatic cancer PC-3 cells and promote apoptosis of the prostatic cancer PC-3 cells, and also can significantly inhibit dryness, migration, adhesion and colony formation of the PC-3 cells.

Description

technical field [0001] The invention relates to the application of diosmin in the preparation of medicine for treating prostate cancer. Background technique [0002] Prostate cancer (PCa) is one of the most common malignant tumors in men, and PCa bone metastasis is the main cause of death in patients with advanced prostate cancer. Studies have found that 90% of patients who die from metastatic prostate cancer have bone metastases. Bone metastases in PCa lead to severe pain, limited mobility, and impair the patient's quality of life. The main treatment methods for patients with advanced cancer include methods such as radiation therapy, chemotherapy and surgery. However, the median survival time of patients with PCa bone metastases after treatment is only 3-5 years. Tumor cell invasion and osteoclast activation are the pathological basis of PCa bone metastasis, so targeting tumor cells in the pathogenesis of PCa bone metastasis is still one of the current therapeutic priori...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P35/00
CPCA61K31/352A61P35/00
Inventor 瓦庆德黄帅吴涛范青洪王斌廖壮文陈灿伟
Owner 遵义医科大学第二附属医院
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