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Spreading gene for acute exacerbation of chronic obstructive pulmonary disease and application thereof in predicting susceptible acute exacerbation of chronic obstructive pulmonary disease

A susceptibility gene, acute exacerbation technology, applied in the field of biomedicine, can solve problems such as limited results, and achieve the effect of wide application prospects

Pending Publication Date: 2022-04-29
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are many related studies on acute exacerbation of chronic obstructive pulmonary disease (COPD) at home and abroad, but the achievements in predicting the genes related to acute exacerbation are very limited

Method used

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  • Spreading gene for acute exacerbation of chronic obstructive pulmonary disease and application thereof in predicting susceptible acute exacerbation of chronic obstructive pulmonary disease
  • Spreading gene for acute exacerbation of chronic obstructive pulmonary disease and application thereof in predicting susceptible acute exacerbation of chronic obstructive pulmonary disease
  • Spreading gene for acute exacerbation of chronic obstructive pulmonary disease and application thereof in predicting susceptible acute exacerbation of chronic obstructive pulmonary disease

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Embodiment 1

[0111] 1. Sample information

[0112] The initial cohort sample information is shown in Table 1, and the validation cohort sample information is shown in Table 2. The samples used were peripheral blood samples. Among them, N represents patients with stable COPD, and P represents patients with acute exacerbation of COPD. The inclusion criteria are: all meet the diagnostic criteria of COPD, the forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC) of all patients is <70%, and there is no acute exacerbation within 3 months before sampling in stable patients; Acute exacerbation was defined as an acute exacerbation requiring a change in the original treatment regimen. The exclusion criteria were: patients with bronchial asthma, lung tumors, tuberculosis, interstitial lung disease and other chronic lung diseases.

[0113] Table 1. Initial cohort sample information

[0114]

[0115]

[0116] Table 2. Validation cohort sample information

[0117]

[0118...

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Abstract

The invention discloses a susceptible gene for acute exacerbation of chronic obstructive pulmonary disease and application of the susceptible gene in prediction of susceptible acute exacerbation of chronic obstructive pulmonary disease. Clinical specimens such as blood of a patient in the chronic obstructive pulmonary disease acute exacerbation stage are collected, blood circulation DNA whole exons of the COPD patient are detected through a genomics technology, and 20 AECOPD specific susceptibility genes are obtained by comparing the gene difference of the whole exons of the chronic obstructive pulmonary disease patient in the stable stage and the acute exacerbation stage; through gene detection of a verification queue, a highly specific gene for predicting acute exacerbation of chronic obstructive pulmonary disease is identified in the 20 genes, and can be used for screening susceptible patients with acute exacerbation of chronic obstructive pulmonary disease, so that a basis is provided for researching and verifying prognosis and recurrence markers of susceptible acute exacerbation of chronic obstructive pulmonary disease in a larger clinical sample in the future; wide application prospects are realized.

Description

technical field [0001] The invention relates to the susceptibility gene for acute exacerbation of chronic obstructive pulmonary disease and its application in predicting susceptibility to acute exacerbation of chronic obstructive pulmonary disease in the field of biomedicine. Background technique [0002] Chronic obstructive pulmonary disease (COPD), referred to as COPD, is a group of chronic airway diseases characterized by persistent respiratory symptoms and airflow limitation. According to the forecast of the World Health Organization, by 2020, COPD will become the fifth largest economic burden in the world and the third leading cause of death worldwide. Smoking, air pollution, occupational exposure and other factors can lead to COPD, among which only 10% to 20% of smokers develop into COPD, but 25% of COPD patients never smoke throughout their lives. Lung obstruction is the result of a combination of genetic and environmental factors. Clinically, COPD can be divided in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156C12Q2600/158
Inventor 肖毅王婧赵红梅苏琳凡韩志发黄蓉罗金梅胡惠元王晓娜曹文浩郭俊伟王宇鑫王龙飞
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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