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Microfluidic system and quantitative device of microchannel thereof

A quantitative device and micro-channel technology, applied to laboratory containers, laboratory utensils, chemical instruments and methods, etc., can solve problems such as inability to achieve parallelism and complicated control methods, and achieve high reliability, accurate quantification and stability saved effect

Pending Publication Date: 2022-05-27
天津威高分子诊断科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, when the liquid fills the quantitative microcavity, the next reaction starts immediately, that is, the process is in a serial relationship and cannot be parallelized, and the overall reaction end time is limited by the slowest reaction hole
[0005] When using the method of power source + switching valve for microfluidic quantification and switching, it is necessary to connect a large number of channels to the gas valve layer interface on different microfluidic channels, and control the air pressure through the opening and closing of the solenoid valve, and then drive Microfluidics, resulting in complex control methods, and the airtightness between the gas channel and the microfluidic channel needs to be paid attention to

Method used

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  • Microfluidic system and quantitative device of microchannel thereof
  • Microfluidic system and quantitative device of microchannel thereof
  • Microfluidic system and quantitative device of microchannel thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] like figure 1 and figure 2 As shown in the figure, the quantitative device of the microchannel includes one liquid inflow channel 1 and three branch flow channels 2, and the heights of the branch flow channels 2 are different, which can be realized by setting the plate body 6 vertically or inclined; The branch flow channel 2 corresponds to a quantitative chamber 3, a cut-off portion 4, and also includes a gas discharge channel 5 in this embodiment; when the externally provided driving force passes through the gas discharge channel 5, it is approximately evenly distributed to each branch flow channel 2, and act on the liquid inflow channel 1 to drive the liquid into the structure. When the liquid reaches the branch channel 2, the size of the driving force is not enough to drive the liquid to overcome its own gravity and pass the branch channel with a higher position. 2 into the quantitative chamber 3 corresponding to the branch channel 2, so the liquid first passes int...

Embodiment 2

[0064] like image 3 As shown, an adsorption member 8 for quantitatively absorbing liquid is provided in the quantitative chamber 3. When a certain amount of liquid enters the quantitative chamber 3 of the first branch flow channel 2, it is captured and fixed by the adsorption member 8 until the adsorption member 8 reaches Saturated, the excess liquid overflows and comes into contact with the cut-off portion 4, and the swelling material in the cut-off portion 4 rapidly undergoes swelling or cross-linking reaction after encountering the liquid, and the volume expands, thereby blocking the transmission of the driving force through the branch channel 2, realizing The cutoff of the branch flow channel 2 . At this time, the driving force can only act on the liquid inflow channel 1 and drive the liquid through the second and third branch flow channels 2 at higher positions, and the liquid enters the second branch flow channel 2 and fills the second branch flow channel as described a...

Embodiment 3

[0066] like Figure 4 As shown, in the quantitative device of the microchannel, in the same branch channel 2, there can be corresponding quantitative chambers 3 in different numbers, and in different branch channels 2, the number of quantitative chambers 3 can be the same or Different; when multiple quantitative chambers 3 are arranged in a branch flow channel 2, the beneficial effect that can be produced is that the signals reacting in the quantitative chamber 3 need to be measured in parallel for multiple times to ensure the true and stable data. At the same time, the parallel comparison of the detection results can be achieved through a plurality of parallel quantitative chambers 3 .

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Abstract

The invention discloses a microfluidic system and a quantitative device of a microchannel thereof, the quantitative device comprises at least one branch flow channel, the first end of the branch flow channel is connected with a liquid inflow channel, and the second end of the branch flow channel is connected with a gas exhaust channel; a cut-off part and at least one quantitative chamber are arranged on the branch flow channel, and the cut-off part is located on the side, close to the gas exhaust channel, of the branch flow channel; the cut-off part is filled with an expansion material, and the expansion material can expand to cut off the branch flow channel after absorbing liquid. According to the quantifying device provided by the invention, the cut-off part and the quantifying chamber are arranged, after the quantifying chamber completes quantification of microfluid, liquid flows into the cut-off part, and under the action of the expansion material, cut-off of the branch flow channel is realized, and the liquid cannot be continuously conveyed to the branch flow channel, so that the quantifying purpose is completed; the device is accurate in quantification, stable storage of liquid can be achieved, under the condition that other parts of the system continue to operate, the risks of liquid leakage and seepage are avoided, and reliability is high.

Description

technical field [0001] The invention relates to the field of microfluidic devices, in particular to a quantitative device for microchannels. In addition, the present invention also relates to a microfluidic system comprising the above-mentioned microchannel quantitative device. Background technique [0002] Microfluidic technology refers to the technology that reasonably controls micro-volume fluids in the millimeter to micrometer scale and realizes corresponding functions. [0003] In the prior art, the method of quantifying and distributing microfluid is mainly carried out by means of volume limitation of the micro-quantity cavity and the method of power source + switching valve. The method of defining the volume of the micro-quantitative chamber. The principle is to centrifuge or squeeze the liquid into one or more micro-volume chambers by external force. The volume of the micro-chamber is equal to or less than the volume of the liquid. and repeat settings for equal dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/502769
Inventor 徐为峰黄宝福徐金喆
Owner 天津威高分子诊断科技有限公司
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