Stable danshen and peach mixture and industrial preparation process thereof

A preparation process and mixture technology, which is applied in the field of dantao mixture and its industrialized preparation process, can solve the problems of bad taste, degradation of symbolic components, and unsatisfactory clarity of dantao mixture, and achieve good clarity and pH value. Effects of stabilization and improvement of medication compliance

Pending Publication Date: 2022-06-03
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of this, the main purpose of the present invention is to provide a kind of industrialized preparation process of stable dantao mixture, to solve the bad mouthfeel of dantao mixture existing in the prior art, unsatisfactory clarity and symbolic signs in the long-term placement process. Severe degradation of ingredients and problems with elevated pH

Method used

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  • Stable danshen and peach mixture and industrial preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of Dantao mixture

[0034] 1. Recipe: in batches of 3.6 million ml

[0035] Weigh each raw material according to the formula in Table 1 below:

[0036] Table 1 Prescription ratio table

[0037] Material name Dosage peach kernel 720.00kg peony bark 360.00kg Bupleurum 360.00kg dandelion 720.00kg Honeysuckle vine 720.00kg Paeonia lactiflora 360.00kg Citrus aurantium 234.00kg Licorice 126.00kg gelatin 5.76kg

[0038] 2. Preparation

[0039] 1. Dantao mixture distillate and Dantao mixture distillation residue

[0040] Extraction: Press "6m 3 Standard Operating Procedure for Multifunctional Extraction Tank / SOP-SB036" and "V=6m 3 Heat reflux extraction and concentration unit Standard Operating Procedures / SOP-SB037" operation, a total of 954.00kg of Cortex Moutan, Bupleurum, and Citrus aurantium medicinal materials are divided into pots and fed in proportion, and placed in t...

Embodiment 2

[0055] A kind of industrialized preparation technology of stable Dantao mixture, comprising the following steps:

[0056] Weigh the raw materials according to the following proportions:

[0057] 30 parts of peach kernel, 15 parts of peony bark, 15 parts of Bupleurum, 30 parts of dandelion, 30 parts of honeysuckle vine, 15 parts of white peony root, 10 parts of citrus aurantium, 5 parts of licorice.

[0058] 1) the mixture of Cortex Moutan, Bupleurum chinensis, Citrus aurantium is soaked in water for 2.5 hours, the amount of water added is 25 times of the mixture of Cortex Moutan, Bupleurum chinensis, Citrus aurantium, and the immersion is completed after heating and distillation for 5 hours to obtain distillate, distillation residual medicine. liquid and distillation residual medicinal residues, the distillation residual medicinal liquid is filtered to obtain residual filtrate;

[0059] 2) The residual medicinal residues of distillation are mixed with white peony root, licori...

Embodiment 3

[0064] A kind of industrialized preparation technology of stable Dantao mixture, comprising the following steps:

[0065] Weigh the raw materials according to the following proportions:

[0066] 10 parts of peach kernel, 5 parts of peony bark, 5 parts of Bupleurum, 10 parts of dandelion, 10 parts of honeysuckle vine, 5 parts of white peony root, 3 parts of citrus aurantium, 2 parts of licorice.

[0067] 1) the mixture of Cortex Moutan, Bupleurum chinensis, Citrus aurantium is soaked in water for 1.5 hours, and the amount of water added is 20 times of the mixture of Cortex Moutan, Bupleurum chinensis, Citrus Citrus, and the soaking is completed after heating and distillation for 4 hours to obtain distillate, distillation residual medicine. liquid and distillation residual medicinal residues, the distillation residual medicinal liquid is filtered to obtain residual filtrate;

[0068] 2) The residual medicinal residues of distillation are mixed with white peony root, licorice ro...

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Abstract

The industrial preparation process comprises the following steps: soaking moutan bark, radix bupleuri and immature bitter orange in water, heating and distilling to obtain distillate, distillation residual liquid medicine and distillation residual medicine residues, and filtering the distillation residual liquid medicine to obtain residual filtrate; mixing the distillation residue with white paeony root, liquorice, honeysuckle stem, dandelion and peach kernel, adding water for decocting, merging decoction, and filtering to obtain decoction filtrate; combining the decoction filtrate and the residual filtrate, and concentrating into a concentrated solution; adding gelatin into the concentrated solution, uniformly stirring, and standing, so as to obtain a primary product of danshen-peach mixture liquid medicine; and filtering, heating and cooling the primary product of the Danshen mixture liquid medicine, mixing the primary product with the distillate, a sodium benzoate solution, glycerol, sorbitol and water, adjusting the pH value to 4.5-6.5, uniformly stirring, filtering and filling to obtain the Danshen mixture. The prepared product is good in taste and clarity, the content of paeonol and paeoniflorin is stable after acceleration for 6 months, the pH value is stable, and the curative effect of the product is better guaranteed.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, and more particularly, to a stable Dantao mixture and an industrialized preparation process thereof. Background technique [0002] Pelvic inflammatory disease refers to inflammation of the female reproductive organs, connective tissue around the uterus and the pelvic peritoneum. There are two types of pelvic inflammatory disease: acute and chronic. [0003] Pelvic inflammatory disease, especially chronic pelvic inflammatory disease, is a common and frequently-occurring disease in gynecology. The symptoms of this disease are numerous, and it can recur due to fatigue or emotional changes. Chronic pelvic inflammatory disease can also be caused by acute pelvic inflammatory disease that is not properly and thoroughly treated or the patient's physical condition is poor and the course of the disease is prolonged. [0004] There are many drugs on the market for the tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/00A61K47/10A61K47/42A61P15/00A61P31/00
CPCA61K36/736A61K36/71A61K36/65A61K36/233A61K36/288A61K36/355A61K36/752A61K36/484A61K9/0095A61K47/42A61K47/10A61P15/00A61P31/00A61K2236/331A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 陈建伟梅勇袁开超粟冲郭娟张传辉王明洁龙涛杨莉陈犁谯志文
Owner 重庆希尔安药业有限公司
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